Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study.

abstract：OBJECTIVES:We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation. METHODS:The hippocampus from KA-treated mice and hippocampal cell cultures were used to evaluate the pathways regulated by chronic lithium pretreatment in both in vivo...

journal_title：Bipolar disorders

authors： Crespo-Biel N,Camins A,Canudas AM,Pallàs M

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Extensive preclinical and clinical evidence suggests mitochondrial dysfunction in bipolar disorder. Studies of brain energy metabolism in bipolar disorder suggest an impairment of energy generation by mitochondrial oxidative phosphorylation. Lithium is an effective drug widely used in treating bipolar disord...

journal_title：Bipolar disorders

authors： Maurer IC,Schippel P,Volz HP

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:Mental imagery abnormalities occur across psychopathologies and are hypothesized to drive emotional difficulties in bipolar disorder (BD). A comprehensive assessment of mental imagery in BD is lacking. We aimed to test whether (i) mental imagery abnormalities (abnormalities in cognitive stages and subjective...

journal_title：Bipolar disorders

authors： Di Simplicio M,Renner F,Blackwell SE,Mitchell H,Stratford HJ,Watson P,Myers N,Nobre AC,Lau-Zhu A,Holmes EA

更新日期：2016-12-01 00:00:00

abstract：:Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...

journal_title：Bipolar disorders

authors： Savitz J,Solms M,Ramesar R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...

journal_title：Bipolar disorders

authors： Di Daniel E,Mudge AW,Maycox PR

更新日期：2005-02-01 00:00:00

abstract：:Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...

journal_title：Bipolar disorders

authors： McIntyre R,Katzman M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes...

journal_title：Bipolar disorders

authors： Zak N,Bøen E,Boye B,Andreassen OA,Doan NT,Malt UF,Westlye LT,Elvsåshagen T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxi...

journal_title：Bipolar disorders

authors： Frey BN,Martins MR,Petronilho FC,Dal-Pizzol F,Quevedo J,Kapczinski F

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...

journal_title：Bipolar disorders

authors： Kamath V,Paksarian D,Cui L,Moberg PJ,Turetsky BI,Merikangas KR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...

journal_title：Bipolar disorders

authors： Fasmer OB,Oedegaard KJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...

journal_title：Bipolar disorders

authors： Meyer TD,Crist N,La Rosa N,Ye B,Soares JC,Bauer IE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...

journal_title：Bipolar disorders

authors： Frangou S,Dakhil N,Landau S,Kumari V

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To identify the risk factors for suicidal ideation in subjects with bipolar depression. METHODS:One-hundred and thirty subjects diagnosed with bipolar depression were evaluated on the following scales: Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Patient Health Questionnaire-15 (PHQ-15), B...

journal_title：Bipolar disorders

authors： Umamaheswari V,Avasthi A,Grover S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...

journal_title：Bipolar disorders

authors： Chengappa KN,Levine J,Gershon S,Mallinger AG,Hardan A,Vagnucci A,Pollock B,Luther J,Buttenfield J,Verfaille S,Kupfer DJ

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:To evaluate frequency and severity of separation anxiety (SA) symptoms, as well as frequency of DSM-IV diagnosis of childhood separation anxiety disorder (CSAD) and adult separation anxiety disorder (ASAD), in a group of patients with bipolar disorder (BD) when compared with patients with panic disorder (PD)...

journal_title：Bipolar disorders

authors： Pini S,Abelli M,Mauri M,Muti M,Iazzetta P,Banti S,Cassano GB

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...

journal_title：Bipolar disorders

authors： Bopp JM,Miklowitz DJ,Goodwin GM,Stevens W,Rendell JM,Geddes JR

更新日期：2010-05-01 00:00:00

abstract：:The widely held clinical view of 'antidepressants' as highly effective and specific for the treatment of all types of depressive disorders is exaggerated. This sobering conclusion is supported by recent findings from the NIMH-sponsored STEP-BD and STAR*D projects. Antidepressants have limited short-term efficacy in un...

journal_title：Bipolar disorders

authors： Ghaemi SN

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in b...

journal_title：Bipolar disorders

authors： Bonaccorso S,Sodhi M,Li J,Bobo WV,Chen Y,Tumuklu M,Theleritis C,Jayathilake K,Meltzer HY

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment-related changes in emotion processing networks in youth at familial high risk ...

journal_title：Bipolar disorders

authors： Garrett AS,Chang KD,Singh MK,Armstrong CC,Walshaw PD,Miklowitz DJ

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Approximate entropy (ApEn) measures regularity in time series data, while traditional linear statistics measure variability. Using self-reported mood data from patients with bipolar disorder, this preliminary study addressed whether ApEn could distinguish (i) the 60 days prior to the start of a manic or depr...

journal_title：Bipolar disorders

authors： Glenn T,Whybrow PC,Rasgon N,Grof P,Alda M,Baethge C,Bauer M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...

journal_title：Bipolar disorders

authors： Sachs G,Chengappa KN,Suppes T,Mullen JA,Brecher M,Devine NA,Sweitzer DE

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...

journal_title：Bipolar disorders

authors： Regenold WT,D'Agostino CA,Ramesh N,Hasnain M,Roys S,Gullapalli RP

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Bipolar disorders are associated with high rates of suicide attempts (SAs) and completions. Several factors have been reported to be associated with suicide in persons with bipolar disorder, but most studies to date have been retrospective and have not utilized multivariate statistics to account for the redu...

journal_title：Bipolar disorders

authors： Marangell LB,Bauer MS,Dennehy EB,Wisniewski SR,Allen MH,Miklowitz DJ,Oquendo MA,Frank E,Perlis RH,Martinez JM,Fagiolini A,Otto MW,Chessick CA,Zboyan HA,Miyahara S,Sachs G,Thase ME

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post-hoc analysis evaluated the association between obesity and the presen...

journal_title：Bipolar disorders

authors： Petri E,Bacci O,Barbuti M,Pacchiarotti I,Azorin JM,Angst J,Bowden CL,Mosolov S,Vieta E,Young AH,Perugi G,BRIDGE-II-Mix Study Group.

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS:We assessed polarity at onset in patie...

journal_title：Bipolar disorders

authors： Forty L,Jones L,Jones I,Smith DJ,Caesar S,Fraser C,Gordon-Smith K,Hyde S,Craddock N

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) is a common and highly disabling disease characterized by substantial cognitive and functional impairment. The exact neurobiological mechanisms underlying the expression of symptoms in this condition remain unknown but there is growing evidence that glutamate might play an important rol...

journal_title：Bipolar disorders

authors： Gigante AD,Bond DJ,Lafer B,Lam RW,Young LT,Yatham LN

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:Despite known metabolic effects of second-generation antipsychotics (SGAs) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. We compared differences in metabolic changes three months after starting treatment with SGAs in youth with bipolar disorder and w...

journal_title：Bipolar disorders

authors： Moreno C,Merchán-Naranjo J,Alvarez M,Baeza I,Alda JA,Martínez-Cantarero C,Parellada M,Sánchez B,de la Serna E,Giráldez M,Arango C

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...

journal_title：Bipolar disorders

authors： Glahn DC,Bearden CE,Caetano S,Fonseca M,Najt P,Hunter K,Pliszka SR,Olvera RL,Soares JC

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...

journal_title：Bipolar disorders

authors： Kim EY,Miklowitz DJ

更新日期：2002-08-01 00:00:00

abstract：:It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...

journal_title：Bipolar disorders

authors： Chen G,Masana MI,Manji HK

更新日期：2000-09-01 00:00:00