Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmas.

abstract：OBJECTIVES:Bipolar affective disorder (BPAD) is clinically and genetically heterogeneous and the affected phenotype is poorly defined, hampering studies of its genetic basis. Studies of specific, familial, clinical indicators of BPAD may be useful for identifying heritable forms. Homogeneous forms of the disease may be...

journal_title：Bipolar disorders

authors： Etain B,Roy I,Henry C,Rousseva A,Schürhoff F,Leboyer M,Bellivier F

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Although it is well established that euthymic patients with bipolar disorder can have cognitive impairment, substantial heterogeneity exists and little is known about the extent and severity of impairment within the bipolar II disorder subtype. Therefore, the main aim of this study was to analyze cognitive v...

journal_title：Bipolar disorders

authors： Solé B,Jiménez E,Torrent C,Del Mar Bonnin C,Torres I,Reinares M,Priego Á,Salamero M,Colom F,Varo C,Vieta E,Martínez-Arán A

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...

journal_title：Bipolar disorders

authors： Kamath V,Paksarian D,Cui L,Moberg PJ,Turetsky BI,Merikangas KR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:  Inflammation and other immune processes are increasingly linked to psychiatric diseases. Antigenic triggers specific to bipolar disorder are not yet defined. We tested whether antibodies to bovine milk caseins were associated with bipolar disorder, and whether patients recognized different epitopes of the ...

journal_title：Bipolar disorders

authors： Severance EG,Dupont D,Dickerson FB,Stallings CR,Origoni AE,Krivogorsky B,Yang S,Haasnoot W,Yolken RH

更新日期：2010-12-01 00:00:00

abstract：:Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium. valproate and inositol targets may be combined readily. It has been shown that lithium inhibits yeast inositol monophosphatase (enc...

journal_title：Bipolar disorders

authors： Agam G,Shamir A,Shaltiel G,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of the dopaminergic-enhancing agent modafinil/armodafinil (MoArm) as adjunctive treatment for bipolar depression. METHODS:A comprehensive search of major electronic databases was conducted to identify randomized controlled trials (RCTs) of adjunct...

journal_title：Bipolar disorders

authors： Nunez NA,Singh B,Romo-Nava F,Joseph B,Veldic M,Cuellar-Barboza A,Cabello Arreola A,Vande Voort JL,Croarkin P,Moore KM,Biernacka J,McElroy SL,Frye MA

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:A post hoc analysis of pooled data from two quetiapine monotherapy clinical trials was conducted to evaluate the efficacy and tolerability of quetiapine therapy (twice daily, 400-800 mg/day) among bipolar manic adults aged 55 years and older. The primary efficacy endpoint was the change from baseline in Youn...

journal_title：Bipolar disorders

authors： Sajatovic M,Calabrese JR,Mullen J

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

journal_title：Bipolar disorders

authors： Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date. OBJECTIVES:To estimate...

journal_title：Bipolar disorders

authors： Holtmann M,Bölte S,Goth K,Döpfner M,Plück J,Huss M,Fegert JM,Lehmkuhl G,Schmeck K,Poustka F

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:Pediatric bipolar disorder is currently diagnosed based on signs and symptoms, and without objective diagnostic biomarkers. In the present study, we investigated the utility of structural neuroanatomical signatures of the amygdala to objectively differentiate individual subjects with pediatric bipolar disord...

journal_title：Bipolar disorders

authors： Mwangi B,Spiker D,Zunta-Soares GB,Soares JC

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Recent theories regarding the neuropathology of bipolar disorder suggest that both neurodevelopmental and neurodegenerative processes may play a role. While magnetic resonance imaging has provided significant insight into the structural, functional, and connectivity abnormalities associated with bipolar disor...

journal_title：Bipolar disorders

authors： Schneider MR,DelBello MP,McNamara RK,Strakowski SM,Adler CM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment-related changes in emotion processing networks in youth at familial high risk ...

journal_title：Bipolar disorders

authors： Garrett AS,Chang KD,Singh MK,Armstrong CC,Walshaw PD,Miklowitz DJ

更新日期：2021-01-12 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...

journal_title：Bipolar disorders

authors： Gopin CB,Burdick KE,Derosse P,Goldberg TE,Malhotra AK

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...

journal_title：Bipolar disorders

authors： Ferrier IN,Chowdhury R,Thompson JM,Watson S,Young AH

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Topiramate, a newer antiepileptic agent, may benefit several neurological and psychiatric states, including bipolar disorder. CASE REPORT:A physically healthy, stockily built, 47-year-old, hypomanic Asian male with a >20-year history of uneventful use of psychotropic agents received topiramate in a dose tha...

journal_title：Bipolar disorders

authors： Andrade C

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:Randomized trials of adjunctive psychotherapy for bipolar disorder are reviewed, in tandem with discussion of cost-effectiveness, mediating mechanisms, and moderators of effects. METHODS:Systematic searches of the MEDLINE and PSYCHLIT databases yielded 19 randomized controlled trials of individual family an...

journal_title：Bipolar disorders

authors： Miklowitz DJ,Scott J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. METHODS:A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with bipolar I ...

journal_title：Bipolar disorders

authors： Kwentus J,Riesenberg RA,Marandi M,Manning RA,Allen MH,Fishman RS,Spyker DA,Kehne JH,Cassella JV

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...

journal_title：Bipolar disorders

authors： de Vries C,van Bergen A,Regeer EJ,Benthem E,Kupka RW,Boks MP

更新日期：2013-09-01 00:00:00

abstract：:Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium...

journal_title：Bipolar disorders

authors： Levy NA,Janicak PG

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:To evaluate frequency and severity of separation anxiety (SA) symptoms, as well as frequency of DSM-IV diagnosis of childhood separation anxiety disorder (CSAD) and adult separation anxiety disorder (ASAD), in a group of patients with bipolar disorder (BD) when compared with patients with panic disorder (PD)...

journal_title：Bipolar disorders

authors： Pini S,Abelli M,Mauri M,Muti M,Iazzetta P,Banti S,Cassano GB

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:In this report, we seek to (i) identify a potential neuroimaging endophenotype for bipolar disorder (BD) in emotion regulatory and autonomic circuitry in young first-degree relatives of persons with BD; and (ii) replicate our previous work identifying the functional neuroanatomy of working memory (WM) in an ...

journal_title：Bipolar disorders

authors： Thermenos HW,Makris N,Whitfield-Gabrieli S,Brown AB,Giuliano AJ,Lee EH,Faraone SV,Tsuang MT,Seidman LJ

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Neurovascular abnormalities are relevant to the pathophysiology of bipolar disorder (BD), which can be assessed using cerebral blood flow (CBF) imaging. CBF alterations have been identified in BD, but studies to date have been small and inconclusive. We aimed to determine cortical gray matter CBF (GM-CBF) di...

journal_title：Bipolar disorders

authors： Zeng V,Lizano P,Bolo NR,Lutz O,Brady R Jr,Ivleva EI,Dai W,Clementz B,Tamminga C,Pearlson G,Keshavan M

更新日期：2020-06-24 00:00:00

abstract：OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...

journal_title：Bipolar disorders

authors： Bjoerke-Bertheussen J,Schoeyen H,Andreassen OA,Malt UF,Oedegaard KJ,Morken G,Sundet K,Vaaler AE,Auestad B,Kessler U

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To examine gender differences in a large sample of patients with bipolar illness. METHODS:Exploratory analysis of baseline data from the first 500 patients in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), a multi-center NIMH project. Participants are allowed to have medical and...

journal_title：Bipolar disorders

authors： Baldassano CF,Marangell LB,Gyulai L,Ghaemi SN,Joffe H,Kim DR,Sagduyu K,Truman CJ,Wisniewski SR,Sachs GS,Cohen LS

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...

journal_title：Bipolar disorders

authors： Chengappa KN,Levine J,Gershon S,Mallinger AG,Hardan A,Vagnucci A,Pollock B,Luther J,Buttenfield J,Verfaille S,Kupfer DJ

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Bipolar illness is frequently misdiagnosed. Several studies have focused on the underdiagnosis of this condition and the frequent long delay in its recognition. However, the illness is difficult to diagnose and many of its symptoms are shared by other conditions. In order to determine the accuracy of the dia...

journal_title：Bipolar disorders

authors： Stewart C,El-Mallakh RS

更新日期：2007-09-01 00:00:00

abstract：:It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...

journal_title：Bipolar disorders

authors： Chen G,Masana MI,Manji HK

更新日期：2000-09-01 00:00:00

abstract：:Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

journal_title：Bipolar disorders

authors： Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...

journal_title：Bipolar disorders

authors： MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonan...

journal_title：Bipolar disorders

authors： Frey BN,Stanley JA,Nery FG,Monkul ES,Nicoletti MA,Chen HH,Hatch JP,Caetano SC,Ortiz O,Kapczinski F,Soares JC

更新日期：2007-06-01 00:00:00