Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs.

abstract：OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...

journal_title：Bipolar disorders

authors： Bjoerke-Bertheussen J,Schoeyen H,Andreassen OA,Malt UF,Oedegaard KJ,Morken G,Sundet K,Vaaler AE,Auestad B,Kessler U

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. METHODS:Children and adolescents offsprin...

journal_title：Bipolar disorders

authors： Nery FG,Weber WA,Blom TJ,Welge J,Patino LR,Strawn JR,Chu WJ,Adler CM,Komoroski RA,Strakowski SM,DelBello MP

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...

journal_title：Bipolar disorders

authors： Cousins DA,Butts K,Young AH

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:We combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD). METHODS:We acquired whole-brain fMRI data in 21 patients with BD an...

journal_title：Bipolar disorders

authors： Oertel-Knöchel V,Reinke B,Feddern R,Knake A,Knöchel C,Prvulovic D,Pantel J,Linden DE

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...

journal_title：Bipolar disorders

authors： de Vries C,van Bergen A,Regeer EJ,Benthem E,Kupka RW,Boks MP

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine. METHODS:The sample included 164 subjects from 21 families of bipolar probands, 14 responders to lithium and seven to lamotrigine. Diagnostic inform...

journal_title：Bipolar disorders

authors： Passmore MJ,Garnham J,Duffy A,MacDougall M,Munro A,Slaney C,Teehan A,Alda M

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD). METHODS:Adolescents (n = 80), between the ages of 12 and 21 years (mean = 15.6, standard deviation = 2.3), hospitalized for their initial manic or mixed episode of BD, were ev...

journal_title：Bipolar disorders

authors： Barzman DH,DelBello MP,Fleck DE,Lehmkuhl H,Strakowski SM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...

journal_title：Bipolar disorders

authors： Fasmer OB,Oedegaard KJ

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:To investigate the use of transcranial direct current stimulation (tDCS) for enhancing working memory and sustained attention in euthymic patients with bipolar disorder. METHODS:Fifteen patients with bipolar disorder received anodal left prefrontal tDCS with an extracephalic cathode (prefrontal condition), ...

journal_title：Bipolar disorders

authors： Martin DM,Chan HN,Alonzo A,Green MJ,Mitchell PB,Loo CK

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...

journal_title：Bipolar disorders

authors： Rodríguez-Cano E,Alonso-Lana S,Sarró S,Fernández-Corcuera P,Goikolea JM,Vieta E,Maristany T,Salvador R,McKenna PJ,Pomarol-Clotet E

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...

journal_title：Bipolar disorders

authors： Gomes BC,Rocca CC,Belizario GO,de B F Fernandes F,Valois I,Olmo GC,Fachin RVP,Farhat LC,Lafer B

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...

journal_title：Bipolar disorders

authors： Bopp JM,Miklowitz DJ,Goodwin GM,Stevens W,Rendell JM,Geddes JR

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Many morphometric magnetic resonance imaging (MRI) studies that have investigated the presence of gray matter (GM) volume abnormalities associated with the diagnosis of bipolar disorder (BD) have reported conflicting findings. None of these studies has compared patients with recent-onset psychotic BD with as...

journal_title：Bipolar disorders

authors： de Azevedo-Marques Périco C,Duran FL,Zanetti MV,Santos LC,Murray RM,Scazufca M,Menezes PR,Busatto GF,Schaufelberger MS

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age. METHODS:Case register study with linkage of the Danish Psychiatric Central Research Register, including data...

journal_title：Bipolar disorders

authors： Kessing LV,Agerbo E,Mortensen PB

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotiona...

journal_title：Bipolar disorders

authors： Nelson EE,Vinton DT,Berghorst L,Towbin KE,Hommer RE,Dickstein DP,Rich BA,Brotman MA,Pine DS,Leibenluft E

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:In this study, we aimed to determine the role of genetic variations within the zinc finger protein 804A (ZNF804A) gene, a candidate for a psychosis risk-conferring gene, in the development of schizophrenia (SZ) and bipolar disorder (BP) in the Korean population. METHODS:A total of 921 patients with SZ, bipo...

journal_title：Bipolar disorders

authors： Baek JH,Ha K,Kim Y,Yang SY,Cho EY,Choi Y,Ryu S,Lee YS,Park T,Hong KS

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...

journal_title：Bipolar disorders

authors： Conus P,Ward J,Hallam KT,Lucas N,Macneil C,McGorry PD,Berk M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the antimanic efficacy and safety of paliperidone extended-release (ER) tablets in patients with bipolar I disorder. METHODS:This study included a 3-week, double-blind, acute treatment phase (paliperidone ER versus placebo, with quetiapine as control), and a 9-week, double-blind, maintenance pha...

journal_title：Bipolar disorders

authors： Vieta E,Nuamah IF,Lim P,Yuen EC,Palumbo JM,Hough DW,Berwaerts J

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Several lines of evidence suggest that deficits in cognition persist in bipolar patients during periods of euthymia. Working memory impairment has been observed in euthymic bipolar patients and noted to be a significant source of functional deficits in psychiatric disorders. Functional changes associated wit...

journal_title：Bipolar disorders

authors： Adler CM,Holland SK,Schmithorst V,Tuchfarber MJ,Strakowski SM

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Although it is well established that euthymic patients with bipolar disorder can have cognitive impairment, substantial heterogeneity exists and little is known about the extent and severity of impairment within the bipolar II disorder subtype. Therefore, the main aim of this study was to analyze cognitive v...

journal_title：Bipolar disorders

authors： Solé B,Jiménez E,Torrent C,Del Mar Bonnin C,Torres I,Reinares M,Priego Á,Salamero M,Colom F,Varo C,Vieta E,Martínez-Arán A

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suici...

journal_title：Bipolar disorders

authors： Sankar A,Purves K,Colic L,Cox Lippard ET,Millard H,Fan S,Spencer L,Wang F,Pittman B,Constable RT,Gross JJ,Blumberg HP

更新日期：2020-06-10 00:00:00

abstract：OBJECTIVES:To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL). METHODS:Offspring of parents with BP, who were healthy or had non-BP disorders (any psychiatric disorder other than BP...

journal_title：Bipolar disorders

authors： Diler RS,Birmaher B,Axelson D,Obreja M,Monk K,Hickey MB,Goldstein B,Goldstein T,Sakolsky D,Iyengar S,Brent D,Kupfer D

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation. METHODS:The hippocampus from KA-treated mice and hippocampal cell cultures were used to evaluate the pathways regulated by chronic lithium pretreatment in both in vivo...

journal_title：Bipolar disorders

authors： Crespo-Biel N,Camins A,Canudas AM,Pallàs M

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim of this study was to identify clinical predictors of suicide attempts in subjects with bipolar disorder. METHODS:We studied 336 subjects with a diagnosis of bipolar I, bipolar II, or schizoaf...

journal_title：Bipolar disorders

authors： Dalton EJ,Cate-Carter TD,Mundo E,Parikh SV,Kennedy JL

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...

journal_title：Bipolar disorders

authors： Frangou S,Dakhil N,Landau S,Kumari V

更新日期：2006-02-01 00:00:00

abstract：AIMS:To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognit...

journal_title：Bipolar disorders

authors： Gottlieb JF,Benedetti F,Geoffroy PA,Henriksen TEG,Lam RW,Murray G,Phelps J,Sit D,Swartz HA,Crowe M,Etain B,Frank E,Goel N,Haarman BCM,Inder M,Kallestad H,Jae Kim S,Martiny K,Meesters Y,Porter R,Riemersma-van der L

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...

journal_title：Bipolar disorders

authors： Singh J,Mattoo SK,Sharan P,Basu D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...

journal_title：Bipolar disorders

authors： Sachs G,Chengappa KN,Suppes T,Mullen JA,Brecher M,Devine NA,Sweitzer DE

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...

journal_title：Bipolar disorders

authors： Di Daniel E,Mudge AW,Maycox PR

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxi...

journal_title：Bipolar disorders

authors： Frey BN,Martins MR,Petronilho FC,Dal-Pizzol F,Quevedo J,Kapczinski F

更新日期：2006-06-01 00:00:00