Abstract:
OBJECTIVES:To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age. METHODS:Case register study with linkage of the Danish Psychiatric Central Research Register, including data on all admissions at psychiatric wards in Denmark from 1981 to 1998, and the Civil Registration System, including data on death and on socio-demographic variables. All patients who got a diagnosis of mania/mixed episode at the first ever admission at a psychiatric ward and a random gender- and age-matched control group of subjects who had never been admitted to psychiatric ward were identified. RESULTS:A total of 1565 patients and 31,300 control subjects were identified. Suicide of a mother or of a sibling was associated with a highly increased risk of being admitted for the first time ever at a psychiatric ward with a diagnosis of mania/mixed episode. Death of a relative by other causes than suicide was not associated with increased risk of getting hospitalized with mania. Recent unemployment, recent divorce, but also a recent marriage showed moderate effects. No interaction was found on the association between life events and the first admission with mania, totally, or for men or women, separately regarding ageing. CONCLUSIONS:The occurrence of death in the family and the experience of major life events are associated with increased risk of first admission with bipolar disorder. The susceptibility to major life stressors of inducing mania does not seem to change throughout life.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Kessing LV,Agerbo E,Mortensen PBdoi
10.1111/j.1399-5618.2004.00102.xkeywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
122-9issue
2eissn
1398-5647issn
1399-5618pii
102journal_volume
6pub_type
杂志文章abstract::Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.020204.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:This study examined health care resource utilization and direct health care costs among patients diagnosed with bipolar I disorder in a privately insured population. METHODS:Health care claims data for 2883 patients with a primary diagnosis of bipolar disorder were compared over a 1-year period (1997) with c...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01148.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:The present study examined the 5-year longitudinal course of cognitive functioning in a large sample of well-characterized patients with bipolar disorder (BP), compared to healthy controls (HCs), and the influence of cognitive reserve factors (e.g., education and IQ) on cognitive change over time. METHODS:P...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12470
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:A high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of a...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12313
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder is associated with positive emotion disturbance, though it is less clear which specific positive emotions are affected. METHODS:The present study examined differences among distinct positive emotions in recovered bipolar disorder (BD) patients (n = 55) and nonclinical controls (NC) (n = 32)...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00679.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. METHODS:This paper pro...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12821
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2008.00610.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00906.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:The notion that sufferers of bipolar disorder achieve complete syndromal and functional recovery between illness episodes has been brought into question by evidence that a large proportion of patients fail to regain premorbid levels of functioning after the resolution of major affective symptoms. A growing b...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1399-5618.2006.00277.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12126
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00274.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00807.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12611
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12595
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suici...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12954
更新日期:2020-06-10 00:00:00
abstract:OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00267.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00281.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD i...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12141
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00173.x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Several studies have challenged the traditional unipolar-bipolar dichotomy in favor of a more dimensional approach. OBJECTIVE:To evaluate the differences in mood spectrum between patients with bipolar disorder (BD) and major depressive disorder (MDD) during a major depressive episode (MDE). METHOD:Study pa...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12855
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD). METHODS:Adolescents (n = 80), between the ages of 12 and 21 years (mean = 15.6, standard deviation = 2.3), hospitalized for their initial manic or mixed episode of BD, were ev...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00423.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12105
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1399-5618.2000.020107.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:Manic patients exhibit impaired verbal learning and memory, particularly following longstanding illness. However, it is unclear whether recognition and recall performance are differentially influenced by a manic mood state. METHODS:To examine this issue, we administered the California Verbal Learning Test a...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2003.00055.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12164
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Bipolar affective disorder (BPAD) is clinically and genetically heterogeneous and the affected phenotype is poorly defined, hampering studies of its genetic basis. Studies of specific, familial, clinical indicators of BPAD may be useful for identifying heritable forms. Homogeneous forms of the disease may be...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00413.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Treatment-emergent mania (TEM) represents a common phenomenon inconsistently reported across primary studies, warranting further assessment. METHODS:A systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analysis of Observation...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析
doi:10.1111/bdi.12612
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Lithium is often the mood stabilizer of choice for the treatment of type I bipolar disorder. However, side effects as well as the narrow therapeutic dosing range often complicate its use. Lithium toxicity can be fatal and its serum level needs to be closely monitored, especially at the time of introduction a...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12174
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2009.00760.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Recent theories regarding the neuropathology of bipolar disorder suggest that both neurodevelopmental and neurodegenerative processes may play a role. While magnetic resonance imaging has provided significant insight into the structural, functional, and connectivity abnormalities associated with bipolar disor...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2012.01024.x
更新日期:2012-06-01 00:00:00