Abstract:
OBJECTIVES:Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and address cognitive impairment. METHODS:The task force, consisting of 19 international experts from nine countries, discussed the challenges and recommendations in a face-to-face meeting, telephone conference call and email exchanges. Consensus-based recommendations were achieved through these exchanges with no need for formal consensus methods. RESULTS:The identified questions were: (I) Should cognitive screening assessments be routinely conducted in clinical settings? (II) What are the most feasible screening tools? (III) What are the implications if cognitive impairment is detected? (IV) What are the treatment perspectives? Key recommendations are that clinicians: (I) formally screen cognition in partially or fully remitted patients whenever possible, (II) use brief, easy-to-administer tools such as the Screen for Cognitive Impairment in Psychiatry and Cognitive Complaints in Bipolar Disorder Rating Assessment, and (III) evaluate the impact of medication and comorbidity, refer patients for comprehensive neuropsychological evaluation when clinically indicated, and encourage patients to build cognitive reserve. Regarding question (IV), there is limited evidence for current evidence-based treatments but intense research efforts are underway to identify new pharmacological and/or psychological cognition treatments. CONCLUSIONS:This task force paper provides the first consensus-based recommendations for clinicians on whether, when, and how to assess and address cognition, which may aid patients' functional recovery and improve their quality of life.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Miskowiak KW,Burdick KE,Martinez-Aran A,Bonnin CM,Bowie CR,Carvalho AF,Gallagher P,Lafer B,López-Jaramillo C,Sumiyoshi T,McIntyre RS,Schaffer A,Porter RJ,Purdon S,Torres IJ,Yatham LN,Young AH,Kessing LV,Vieta Edoi
10.1111/bdi.12595subject
Has Abstractpub_date
2018-05-01 00:00:00pages
184-194issue
3eissn
1398-5647issn
1399-5618journal_volume
20pub_type
杂志文章,评审abstract:OBJECTIVES:To evaluate frequency and severity of separation anxiety (SA) symptoms, as well as frequency of DSM-IV diagnosis of childhood separation anxiety disorder (CSAD) and adult separation anxiety disorder (ASAD), in a group of patients with bipolar disorder (BD) when compared with patients with panic disorder (PD)...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00216.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:Dopamine transmission abnormalities have been implicated in the etiology of bipolar disorder (BPD). However, there is a paucity of receptor imaging studies in BPD, and little information is available about the dopamine system in BPD. Reuptake of synaptic dopamine by the dopamine transporter (DAT) is the prin...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00936.x
更新日期:2011-06-01 00:00:00
abstract::The Diagnostic Guidelines Task Force of the International Society for Bipolar Disorders (ISBD) presents in this document and this special issue a summary of the current nosological status of bipolar illness, a discussion of possible revisions to current DSM-IV and ICD-10 definitions, an examination of the relevant lit...
journal_title:Bipolar disorders
pub_type: 杂志文章,实务指引
doi:10.1111/j.1399-5618.2007.00556.x
更新日期:2008-02-01 00:00:00
abstract:INTRODUCTION:Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative th...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12622
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5618.2008.00455.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from nine population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and de...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12732
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01226.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:To identify the risk factors for suicidal ideation in subjects with bipolar depression. METHODS:One-hundred and thirty subjects diagnosed with bipolar depression were evaluated on the following scales: Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Patient Health Questionnaire-15 (PHQ-15), B...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12179
更新日期:2014-09-01 00:00:00
abstract::It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.20303.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES: Inflammation and other immune processes are increasingly linked to psychiatric diseases. Antigenic triggers specific to bipolar disorder are not yet defined. We tested whether antibodies to bovine milk caseins were associated with bipolar disorder, and whether patients recognized different epitopes of the ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00879.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00274.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To report a case report of a geriatric patient with a 5-year history of gabapentin use for enhanced bipolar control, who was tapered off of gabapentin over 1 week. The patient displayed unique withdrawal symptoms after the taper of gabapentin. METHODS:The patient is an 81-year-old white female with a life-lo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00200.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:This study examined health care resource utilization and direct health care costs among patients diagnosed with bipolar I disorder in a privately insured population. METHODS:Health care claims data for 2883 patients with a primary diagnosis of bipolar disorder were compared over a 1-year period (1997) with c...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01148.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00525.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1399-5618.2000.020107.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:To determine the effects of mood and additional clinical variables on different domains of current interviewer-rated social adjustment reflecting the reported behaviour of patients with bipolar disorder (BD). METHOD:Multi-center cross-sectional study employing multiple linear regression to investigate wheth...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1399-5618.2007.00343.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of the dopaminergic-enhancing agent modafinil/armodafinil (MoArm) as adjunctive treatment for bipolar depression. METHODS:A comprehensive search of major electronic databases was conducted to identify randomized controlled trials (RCTs) of adjunct...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析
doi:10.1111/bdi.12859
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder is associated with positive emotion disturbance, though it is less clear which specific positive emotions are affected. METHODS:The present study examined differences among distinct positive emotions in recovered bipolar disorder (BD) patients (n = 55) and nonclinical controls (NC) (n = 32)...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00679.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation-wide population-based registers to investigate whether continued use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin, high-dose aspirin, statins, allopurinol, and...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12772
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12906
更新日期:2020-09-01 00:00:00
abstract::Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2005.00203.x
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/bdi.12006
更新日期:2012-11-01 00:00:00
abstract::Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-2406.2003.00061.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:We combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD). METHODS:We acquired whole-brain fMRI data in 21 patients with BD an...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12241
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Mismatch negativity (MMN) and its magnetic counterpart (MMNm) are thought to reflect an automatic process that detects a difference between an incoming stimulus and the sensory memory trace of preceding stimuli. In patients with schizophrenia, an attenuation of the MMN/MMNm amplitude has been repeatedly repo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12208
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. METHODS:Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章
doi:10.1111/j.1399-5618.2006.00335.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation. METHODS:The hippocampus from KA-treated mice and hippocampal cell cultures were used to evaluate the pathways regulated by chronic lithium pretreatment in both in vivo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00825.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00122.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12247
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00267.x
更新日期:2005-12-01 00:00:00