Abstract:
OBJECTIVES:A high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of alcohol-metabolizing genotypes on bipolar I disorder (BP-I) + AD and bipolar II disorder (BP-II) + AD. METHODS:Healthy controls (HCs) (n = 672) and 18- to 65-year-old patients with BP (BP-I: n = 530; BP-II: n = 788) were recruited. Patients with any other major or minor mental illnesses, neurological disorders, or organic mental disorders were excluded. A polymerase chain reaction and restriction fragment length polymorphism analysis was used to determine genotypes for alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2), two alcohol-metabolizing enzymes. RESULTS:AD comorbidity rates were 11.7% with BP-I and 17.1% with BP-II. Significantly fewer patients with BP not comorbid with AD (BP-AD) carried the AHD1B*1 allele than did the HCs. Logistic regression analysis showed a main effect of ALDH2*1/*1 only in the BP-I-AD group. In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP-II+AD group. CONCLUSIONS:Having BP-II+AD may be related to ALDH2 and ADH1B, but having BP-I+AD may be related only to ALDH2. We conclude that ALDH2 and ADH1B have different effects in Han Chinese patients with BP-I+AD and BP-II+AD.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Chang YH,Lee SY,Wang TY,Chen SL,Tzeng NS,Chen PS,Lee IH,Chen KC,Huang SY,Yang YK,Ko HC,Lu RBdoi
10.1111/bdi.12313subject
Has Abstractpub_date
2015-08-01 00:00:00pages
536-42issue
5eissn
1398-5647issn
1399-5618journal_volume
17pub_type
杂志文章abstract::Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Bipolar disorders
pub_type: 杂志文章
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00267.x
更新日期:2005-12-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12208
更新日期:2014-09-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00274.x
更新日期:2006-02-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2012.01040.x
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1034/j.1399-5618.2003.00017.x
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00807.x
更新日期:2010-05-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/bdi.12400
更新日期:2016-06-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2003.00033.x
更新日期:2003-06-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1399-5618.2006.00277.x
更新日期:2006-04-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1399-5618.2012.01033.x
更新日期:2012-08-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2008.00639.x
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bdi.12222
更新日期:2014-11-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00948.x
更新日期:2011-08-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12091
更新日期:2013-08-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.20303.x
更新日期:2000-09-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00200.x
更新日期:2005-06-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2005.00185.x
更新日期:2005-04-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.13045
更新日期:2021-01-12 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01148.x
更新日期:2002-12-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5618.2005.00237.x
更新日期:2005-10-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析
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更新日期:2018-05-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1399-5618.2008.00614.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation. METHODS:The hippocampus from KA-treated mice and hippocampal cell cultures were used to evaluate the pathways regulated by chronic lithium pretreatment in both in vivo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00825.x
更新日期:2010-06-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1399-5618.2007.00343.x
更新日期:2007-02-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2007.00530.x
更新日期:2007-09-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12128
更新日期:2013-12-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-12-01 00:00:00