Altered frontal-amygdala effective connectivity during effortful emotion regulation in bipolar disorder.

Abstract:

OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation circuit. The aim of this study was to investigate whether BD patients show abnormal effective connectivity from the prefrontal areas to the amygdala during effortful ER (reappraisal). METHODS:Forty participants (23 BD patients and 17 healthy controls [HC]) performed an ER task during functional magnetic resonance imaging. Using dynamic causal modeling, we investigated effective connectivity from the dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) to the amygdala, as well as connectivity between the DLPFC and VLPFC during reappraisal. RESULTS:Both BD patients and HC showed decreased negative affect ratings following reappraisal compared to attending negative pictures (P < .001). There were no group differences (P = .10). There was a differential modulatory effect of reappraisal on the connectivity from the DLPFC to amygdala between BD patients and HC (P = .04), with BD patients showing a weaker modulatory effect on this connectivity compared to HC. There were no other group differences. CONCLUSION:The disturbance in BD patients in effective connectivity from the DLPFC to the amygdala while reappraising is indicative of insufficient prefrontal control. This impairment should be studied further in relation to cycling frequency and polarity of switches in BD patients.

journal_name

Bipolar Disord

journal_title

Bipolar disorders

authors

Zhang L,Opmeer EM,van der Meer L,Aleman A,Ćurčić-Blake B,Ruhé HG

doi

10.1111/bdi.12611

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

349-358

issue

4

eissn

1398-5647

issn

1399-5618

journal_volume

20

pub_type

杂志文章
  • Compliance with the guidelines for laboratory monitoring of patients treated with lithium: A retrospective follow-up study among ambulatory patients in the Netherlands.

    abstract:OBJECTIVES:Laboratory monitoring of patients using lithium is important to prevent harm and to increase effectiveness. The aim of this study is to determine compliance with the guidelines for laboratory monitoring of patients treated with lithium overall and within subgroups. METHODS:Patients having at least one lithi...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12730

    authors: Nederlof M,Egberts TC,van Londen L,de Rotte MC,Souverein PC,Herings RM,Heerdink ER

    更新日期:2019-08-01 00:00:00

  • Ketoconazole in bipolar patients with depressive symptoms: a case series and literature review.

    abstract:BACKGROUND:Data from several studies suggest that medications, such as ketoconazole, which lower cortisol levels, may be effective for major depressive disorder (MDD). As with MDD, the manic, depressive, and mixed phases of bipolar disorder are frequently associated with elevated cortisol levels. The literature on the ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2001.030103.x

    authors: Brown ES,Bobadilla L,Rush AJ

    更新日期:2001-02-01 00:00:00

  • Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.

    abstract:OBJECTIVES:Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suici...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12954

    authors: Sankar A,Purves K,Colic L,Cox Lippard ET,Millard H,Fan S,Spencer L,Wang F,Pittman B,Constable RT,Gross JJ,Blumberg HP

    更新日期:2020-06-10 00:00:00

  • Suicide risk in bipolar patients: the role of co-morbid substance use disorders.

    abstract:OBJECTIVE:Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim of this study was to identify clinical predictors of suicide attempts in subjects with bipolar disorder. METHODS:We studied 336 subjects with a diagnosis of bipolar I, bipolar II, or schizoaf...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1034/j.1399-5618.2003.00017.x

    authors: Dalton EJ,Cate-Carter TD,Mundo E,Parikh SV,Kennedy JL

    更新日期:2003-02-01 00:00:00

  • Suicide risk in people with epilepsy taking antiepileptic drugs.

    abstract:OBJECTIVES:The standardized mortality ratio for suicide in people with epilepsy is reported as 5.1 [95% confidence interval (CI): 3.9-6.6], but this is only partially explained by the high rates of psychiatric comorbidity. This issue was revived when, in 2008, the Food and Drug Administration (FDA) issued an alert on a...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/bdi.12091

    authors: Mula M,Sander JW

    更新日期:2013-08-01 00:00:00

  • Gabapentin withdrawal syndrome in the presence of a taper.

    abstract:OBJECTIVE:To report a case report of a geriatric patient with a 5-year history of gabapentin use for enhanced bipolar control, who was tapered off of gabapentin over 1 week. The patient displayed unique withdrawal symptoms after the taper of gabapentin. METHODS:The patient is an 81-year-old white female with a life-lo...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2005.00200.x

    authors: Tran KT,Hranicky D,Lark T,Jacob Nj

    更新日期:2005-06-01 00:00:00

  • Allopurinol for mania: a randomized trial of allopurinol versus placebo as add-on treatment to mood stabilizers and/or antipsychotic agents in manic patients with bipolar disorder.

    abstract:OBJECTIVE:An emerging body of evidence supports a role for dysfunctional purinergic neurotransmission in mood disorders. Adenosine agonists have been shown to have properties similar to those of dopamine antagonists; there is a well-characterized interaction between adenosine and dopamine receptors in the ventral stria...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bdi.12202

    authors: Weiser M,Burshtein S,Gershon AA,Marian G,Vlad N,Grecu IG,Tocari E,Tiugan A,Hotineanu M,Davis JM

    更新日期:2014-06-01 00:00:00

  • Equally increased risk for metabolic syndrome in patients with bipolar disorder and schizophrenia treated with second-generation antipsychotics.

    abstract:OBJECTIVE:Although second-generation antipsychotics (SGAs) are widely used in treating schizophrenia and bipolar disorder, their effects on dyslipidemia, glucose intolerance, metabolic syndrome (MetS), and coronary heart disease (CHD) risk are less well documented for bipolar disorder. We compared bipolar disorder and ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2008.00625.x

    authors: Correll CU,Frederickson AM,Kane JM,Manu P

    更新日期:2008-11-01 00:00:00

  • Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review.

    abstract:OBJECTIVES:The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psycho...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/bdi.12520

    authors: Smith LM,Johns LC,Mitchell R

    更新日期:2017-09-01 00:00:00

  • The role of dopamine in bipolar disorder.

    abstract:OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-5618.2009.00760.x

    authors: Cousins DA,Butts K,Young AH

    更新日期:2009-12-01 00:00:00

  • Cognitive-behavioral therapy for bipolar disorders in adolescents: a pilot study.

    abstract:OBJECTIVES:To develop a cognitive behavioral intervention for adolescents with bipolar disorders, test its feasibility and preliminary efficacy. METHODS:Based on existing research, a manualized, individually delivered cognitive behavioral intervention was developed and tested with adolescents with bipolar disorders as...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-5618.2006.00358.x

    authors: Feeny NC,Danielson CK,Schwartz L,Youngstrom EA,Findling RL

    更新日期:2006-10-01 00:00:00

  • Glycogen synthase kinase-3β in patients with bipolar I disorder: results from a prospective study.

    abstract:OBJECTIVES:The enzyme glycogen synthase kinase-3β (GSK3β) is involved in the mechanisms of action of lithium and may play a role in relation to affective states in bipolar disorder. The objectives of the present study were to compare the activity of GSK-3β (measured as levels of phosphorylated GSK-3β [p-GSK-3β]) betwee...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bdi.12400

    authors: Jacoby AS,Munkholm K,Vinberg M,Joaquim HG,Talib LL,Gattaz WF,Kessing LV

    更新日期:2016-06-01 00:00:00

  • Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the rat.

    abstract:OBJECTIVES:Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the ingested dose, previous treatment duration and renal function. Whether the severity of lithium-induced encephalopathy depends on the poisoning pattern has not be...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12482

    authors: Hanak AS,Malissin I,Poupon J,Risède P,Chevillard L,Mégarbane B

    更新日期:2017-03-01 00:00:00

  • Missed bipolarity and psychiatric comorbidity in women with postpartum depression.

    abstract:OBJECTIVE:To investigate the diagnostic profile of women referred for postpartum depression. METHODS:Fifty-six women seen consecutively with the referral diagnosis of postpartum depression were administered structured instruments to gather information about their DSM-IV Axis I diagnoses. RESULTS:In terms of frequency...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2008.00606.x

    authors: Sharma V,Khan M,Corpse C,Sharma P

    更新日期:2008-09-01 00:00:00

  • Modeling suicide in bipolar disorders.

    abstract:INTRODUCTION:Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative th...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/bdi.12622

    authors: Malhi GS,Outhred T,Das P,Morris G,Hamilton A,Mannie Z

    更新日期:2018-06-01 00:00:00

  • Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample.

    abstract:OBJECTIVE:  To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study. METHODS:  Children ages 6-12 were recruited at first visit to clinics associated with four universities. A BPSD diagnosis required t...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2011.00948.x

    authors: Arnold LE,Demeter C,Mount K,Frazier TW,Youngstrom EA,Fristad M,Birmaher B,Findling RL,Horwitz SM,Kowatch R,Axelson DA

    更新日期:2011-08-01 00:00:00

  • Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo.

    abstract::It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2000.20303.x

    authors: Chen G,Masana MI,Manji HK

    更新日期:2000-09-01 00:00:00

  • Neuroprotective effects of lithium in cultured cells and animal models of diseases.

    abstract::Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2002.01179.x

    authors: Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

    更新日期:2002-04-01 00:00:00

  • Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report.

    abstract:OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2004.00122.x

    authors: Ferrier IN,Chowdhury R,Thompson JM,Watson S,Young AH

    更新日期:2004-08-01 00:00:00

  • Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course.

    abstract:OBJECTIVES:Patients experiencing an acute mood episode of bipolar disorder are impaired on cognitive tests of executive functioning when compared with healthy subjects. However, it is unclear to what extent executive dysfunction exists (i) during syndromal remission, when mood symptoms are attenuated, and (ii) during t...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2008.00582.x

    authors: Fleck DE,Shear PK,Madore M,Strakowski SM

    更新日期:2008-06-01 00:00:00

  • A population-based morphometric MRI study in patients with first-episode psychotic bipolar disorder: comparison with geographically matched healthy controls and major depressive disorder subjects.

    abstract:OBJECTIVES:Many morphometric magnetic resonance imaging (MRI) studies that have investigated the presence of gray matter (GM) volume abnormalities associated with the diagnosis of bipolar disorder (BD) have reported conflicting findings. None of these studies has compared patients with recent-onset psychotic BD with as...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2011.00896.x

    authors: de Azevedo-Marques Périco C,Duran FL,Zanetti MV,Santos LC,Murray RM,Scazufca M,Menezes PR,Busatto GF,Schaufelberger MS

    更新日期:2011-02-01 00:00:00

  • Hospitalization risks in the treatment of bipolar disorder: comparison of antipsychotic medications.

    abstract:OBJECTIVES:This study compared the relative risk for hospitalization of patients with bipolar and manic disorders receiving atypical and typical antipsychotics. METHODS:This retrospective study was based on administrative claims data extracted from the PharMetrics database during 1999 through 2003. Comparisons were ma...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00394.x

    authors: Gianfrancesco F,Rajagopalan K,Goldberg JF,Wang RH

    更新日期:2007-05-01 00:00:00

  • Population isolates: their special value for locating genes for bipolar disorder.

    abstract:OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2001.30605.x

    authors: Escamilla MA

    更新日期:2001-12-01 00:00:00

  • Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmas.

    abstract:OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2002.01191.x

    authors: Kim EY,Miklowitz DJ

    更新日期:2002-08-01 00:00:00

  • Temporal association as a prerequisite factor of valsartan-induced lithium toxicity.

    abstract:OBJECTIVES:Lithium is often the mood stabilizer of choice for the treatment of type I bipolar disorder. However, side effects as well as the narrow therapeutic dosing range often complicate its use. Lithium toxicity can be fatal and its serum level needs to be closely monitored, especially at the time of introduction a...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12174

    authors: Lazarczyk MJ,Giannakopoulos P

    更新日期:2014-09-01 00:00:00

  • Clinical course of children with a depressive spectrum disorder and transient manic symptoms.

    abstract:OBJECTIVE:To assess rates of conversion to bipolar spectrum disorder (BPSD) and risk factors associated with conversion in children with depressive spectrum disorders (DSD) and transient manic symptoms (TMS) over 18 months. TMS are manic-like symptoms of insufficient duration or number to warrant a diagnosis of BPSD. ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2010.00847.x

    authors: Nadkarni RB,Fristad MA

    更新日期:2010-08-01 00:00:00

  • Cognitive variability in bipolar II disorder: who is cognitively impaired and who is preserved.

    abstract:OBJECTIVES:Although it is well established that euthymic patients with bipolar disorder can have cognitive impairment, substantial heterogeneity exists and little is known about the extent and severity of impairment within the bipolar II disorder subtype. Therefore, the main aim of this study was to analyze cognitive v...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12385

    authors: Solé B,Jiménez E,Torrent C,Del Mar Bonnin C,Torres I,Reinares M,Priego Á,Salamero M,Colom F,Varo C,Vieta E,Martínez-Arán A

    更新日期:2016-05-01 00:00:00

  • Cortical thickness differences between bipolar depression and major depressive disorder.

    abstract:OBJECTIVES:Bipolar disorder (BD) is a psychiatric disorder with high morbidity and mortality that cannot be distinguished from major depressive disorder (MDD) until the first manic episode. A biomarker able to differentiate BD and MDD could help clinicians avoid risks of treating BD with antidepressants without mood st...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12175

    authors: Lan MJ,Chhetry BT,Oquendo MA,Sublette ME,Sullivan G,Mann JJ,Parsey RV

    更新日期:2014-06-01 00:00:00

  • Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

    abstract:OBJECTIVES:To compare the clinical features and course of major depressive episodes (MDEs) occurring in subjects with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD). METHODS:Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (2001-2002)...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2012.01009.x

    authors: Moreno C,Hasin DS,Arango C,Oquendo MA,Vieta E,Liu S,Grant BF,Blanco C

    更新日期:2012-05-01 00:00:00

  • Influence of mood state on capacity to consent to research in patients with bipolar disorder.

    abstract:OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00525.x

    authors: Misra S,Socherman R,Park BS,Hauser P,Ganzini L

    更新日期:2008-03-01 00:00:00