The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness.

abstract：:Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

journal_title：Bipolar disorders

authors： Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Randomized trials of adjunctive psychotherapy for bipolar disorder are reviewed, in tandem with discussion of cost-effectiveness, mediating mechanisms, and moderators of effects. METHODS:Systematic searches of the MEDLINE and PSYCHLIT databases yielded 19 randomized controlled trials of individual family an...

journal_title：Bipolar disorders

authors： Miklowitz DJ,Scott J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the interven...

journal_title：Bipolar disorders

authors： Perlick DA,Jackson C,Grier S,Huntington B,Aronson A,Luo X,Miklowitz DJ

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in b...

journal_title：Bipolar disorders

authors： Bonaccorso S,Sodhi M,Li J,Bobo WV,Chen Y,Tumuklu M,Theleritis C,Jayathilake K,Meltzer HY

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Laboratory monitoring of patients using lithium is important to prevent harm and to increase effectiveness. The aim of this study is to determine compliance with the guidelines for laboratory monitoring of patients treated with lithium overall and within subgroups. METHODS:Patients having at least one lithi...

journal_title：Bipolar disorders

authors： Nederlof M,Egberts TC,van Londen L,de Rotte MC,Souverein PC,Herings RM,Heerdink ER

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...

journal_title：Bipolar disorders

authors： MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...

journal_title：Bipolar disorders

authors： Singh J,Mattoo SK,Sharan P,Basu D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonan...

journal_title：Bipolar disorders

authors： Frey BN,Stanley JA,Nery FG,Monkul ES,Nicoletti MA,Chen HH,Hatch JP,Caetano SC,Ortiz O,Kapczinski F,Soares JC

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative th...

journal_title：Bipolar disorders

authors： Malhi GS,Outhred T,Das P,Morris G,Hamilton A,Mannie Z

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...

journal_title：Bipolar disorders

authors： Bjoerke-Bertheussen J,Schoeyen H,Andreassen OA,Malt UF,Oedegaard KJ,Morken G,Sundet K,Vaaler AE,Auestad B,Kessler U

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:We combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD). METHODS:We acquired whole-brain fMRI data in 21 patients with BD an...

journal_title：Bipolar disorders

authors： Oertel-Knöchel V,Reinke B,Feddern R,Knake A,Knöchel C,Prvulovic D,Pantel J,Linden DE

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Despite known metabolic effects of second-generation antipsychotics (SGAs) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. We compared differences in metabolic changes three months after starting treatment with SGAs in youth with bipolar disorder and w...

journal_title：Bipolar disorders

authors： Moreno C,Merchán-Naranjo J,Alvarez M,Baeza I,Alda JA,Martínez-Cantarero C,Parellada M,Sánchez B,de la Serna E,Giráldez M,Arango C

更新日期：2010-03-01 00:00:00

abstract：:With great interest, we have read the recent paper by Keramatian and colleagues entitled "Grey Matter Abnormalities in First Episode Mania: A Systematic Review and Meta-analysis of Voxel-Based Morphometry Studies" in Bipolar Disorders1 . The authors systematically reviewed 15 voxel-based morphometry (VBM) studies and ...

journal_title：Bipolar disorders

authors： Sheng L,Ma H,Dai Z,Yao L,Hu J

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVE:  To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study. METHODS:  Children ages 6-12 were recruited at first visit to clinics associated with four universities. A BPSD diagnosis required t...

journal_title：Bipolar disorders

authors： Arnold LE,Demeter C,Mount K,Frazier TW,Youngstrom EA,Fristad M,Birmaher B,Findling RL,Horwitz SM,Kowatch R,Axelson DA

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...

journal_title：Bipolar disorders

authors： Di Daniel E,Mudge AW,Maycox PR

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD i...

journal_title：Bipolar disorders

authors： Roiser JP,Cannon DM,Gandhi SK,Taylor Tavares J,Erickson K,Wood S,Klaver JM,Clark L,Zarate CA Jr,Sahakian BJ,Drevets WC

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:As part of a cost-effectiveness analysis for Department of Veterans Affairs Cooperative Studies Program #430, 'Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder,' we conducted a time and motion study to quantify the time psychiatric clinical nurse specialist (CNS) care managers spent providing care...

journal_title：Bipolar disorders

authors： Glick HA,Kinosian B,McBride L,Williford WO,Bauer MS,CSP #430 Study Team.

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:This study examined health care resource utilization and direct health care costs among patients diagnosed with bipolar I disorder in a privately insured population. METHODS:Health care claims data for 2883 patients with a primary diagnosis of bipolar disorder were compared over a 1-year period (1997) with c...

journal_title：Bipolar disorders

authors： Bryant-Comstock L,Stender M,Devercelli G

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVES:A high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of a...

journal_title：Bipolar disorders

authors： Chang YH,Lee SY,Wang TY,Chen SL,Tzeng NS,Chen PS,Lee IH,Chen KC,Huang SY,Yang YK,Ko HC,Lu RB

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxi...

journal_title：Bipolar disorders

authors： Frey BN,Martins MR,Petronilho FC,Dal-Pizzol F,Quevedo J,Kapczinski F

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL). METHODS:Offspring of parents with BP, who were healthy or had non-BP disorders (any psychiatric disorder other than BP...

journal_title：Bipolar disorders

authors： Diler RS,Birmaher B,Axelson D,Obreja M,Monk K,Hickey MB,Goldstein B,Goldstein T,Sakolsky D,Iyengar S,Brent D,Kupfer D

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:The pathophysiological mechanisms underlying bipolar disorder and its multi-system nature are unclear. Oxidatively generated damage to nucleosides has been demonstrated in metabolic disorders; however, the extent to which this occurs in bipolar disorder in vivo is unknown. We investigated oxidatively generat...

journal_title：Bipolar disorders

authors： Munkholm K,Poulsen HE,Kessing LV,Vinberg M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...

journal_title：Bipolar disorders

authors： McKenna BS,Sutherland AN,Legenkaya AP,Eyler LT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Bipolar I disorder is a disabling illness affecting 1% of people worldwide. Family and twin studies suggest that psychotic bipolar disorder (BDP) represents a homogeneous subgroup with an etiology distinct from non-psychotic bipolar disorder (BDNP) and partially shared with schizophrenia. Studies of auditory...

journal_title：Bipolar disorders

authors： Hamm JP,Ethridge LE,Shapiro JR,Pearlson GD,Tamminga CA,Sweeney JA,Keshavan MS,Thaker GK,Clementz BA

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from nine population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and de...

journal_title：Bipolar disorders

authors： Angst J,Rössler W,Ajdacic-Gross V,Angst F,Wittchen HU,Lieb R,Beesdo-Baum K,Asselmann E,Merikangas KR,Cui L,Andrade LH,Viana MC,Lamers F,Penninx BW,de Azevedo Cardoso T,Jansen K,Dias de Mattos Souza L,Azevedo da Silva R

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...

journal_title：Bipolar disorders

authors： Regenold WT,D'Agostino CA,Ramesh N,Hasnain M,Roys S,Gullapalli RP

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation...

journal_title：Bipolar disorders

authors： Zhang L,Opmeer EM,van der Meer L,Aleman A,Ćurčić-Blake B,Ruhé HG

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation. METHODS:The hippocampus from KA-treated mice and hippocampal cell cultures were used to evaluate the pathways regulated by chronic lithium pretreatment in both in vivo...

journal_title：Bipolar disorders

authors： Crespo-Biel N,Camins A,Canudas AM,Pallàs M

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes...

journal_title：Bipolar disorders

authors： Zak N,Bøen E,Boye B,Andreassen OA,Doan NT,Malt UF,Westlye LT,Elvsåshagen T

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. METHODS:Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either...

journal_title：Bipolar disorders

authors： Sharma V,Smith A,Mazmanian D

更新日期：2006-08-01 00:00:00