Abstract：
OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structures, including the corpus callosum. Disruptions in white matter integrity have been demonstrated in BD. However, it is unknown whether alterations in the developmental trajectory of the corpus callosum may contribute to cognitive impairments in the disorder. METHODS:We assessed the area of the corpus callosum and its subregions (the genu, rostral body, anterior and posterior bodies, isthmus, and splenium) in 14 treatment-naïve adolescents with BD (<21 years of age and in the depressed phase) and 18 healthy adolescent controls. RESULTS:In comparison with healthy controls, participants with BD demonstrated a significantly reduced overall corpus callosum area. We also noted smaller areas in the anterior and posterior mid-body of the corpus callosum in adolescents with BD. CONCLUSIONS:Our results suggest that commissural fibers of the corpus callosum are disrupted in early-onset BD. Specific decreases in the anterior and posterior mid-body callosal aspects may contribute to motor organization and inhibition deficits seen in BD. These findings are consistent with the involvement of inter-hemispheric tracts in early-onset BD, which may reflect an early deviation in white matter development.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo Mdoi
10.1111/bdi.12247subject
Has Abstractpub_date
2014-12-01 00:00:00pages
889-93issue
8eissn
1398-5647issn
1399-5618journal_volume
16pub_type
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journal_title：Bipolar disorders
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1111/j.1399-5618.2008.00606.x
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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