Abstract：
BACKGROUND:Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment-related changes in emotion processing networks in youth at familial high risk for bipolar disorder (BD). METHODS:Youth, ages 9-17, were randomly assigned to family-focused therapy for high-risk youth (FFT-HR) or an active comparison treatment, Enhanced Care (EC). Before and after these 4-month treatments, participants underwent fMRI while viewing happy, fearful, and calm facial expressions. Twenty youth in FFT-HR and 20 in EC were included in analyses of pre- to post-treatment changes in activation across the whole brain. Significant clusters were assessed for correlation with mood symptom improvement. RESULTS:In the dorsolateral prefrontal cortex (DLPFC), activation increased from pre- to post-treatment in the FFT-HR group and decreased in the EC group. Insula activation decreased in the FFT-HR group and did not change in the EC group. Across both treatments, decreasing activation in the hippocampus and amygdala was correlated with pre- to post-treatment improvement in hypomania, while increasing activation in the DLPFC was correlated with pre- to post-treatment improvement in depression. DISCUSSION:Psychosocial treatment addresses abnormalities in emotion regulation networks in youth at high risk for BD. Increased prefrontal cortex activation suggests enhanced emotion regulation from pre- to post-treatment with FFT-HR. Improvements in family interactions may facilitate the development of prefrontal resources that provide protection against future mood episodes.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Garrett AS,Chang KD,Singh MK,Armstrong CC,Walshaw PD,Miklowitz DJdoi
10.1111/bdi.13045subject
Has Abstractpub_date
2021-01-12 00:00:00eissn
1398-5647issn
1399-5618pub_type
杂志文章abstract：OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...
journal_title：Bipolar disorders
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1034/j.1399-5618.2003.00033.x
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pub_type： 杂志文章
doi：10.1111/j.1399-5618.2006.00373.x
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pub_type： 杂志文章
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journal_title：Bipolar disorders
pub_type： 杂志文章,多中心研究
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journal_title：Bipolar disorders
pub_type： 杂志文章,评审
doi：10.1111/j.1399-5618.2005.00203.x
更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,meta分析
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更新日期：2018-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1399-5618.2004.00122.x
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/bdi.12732
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1034/j.1399-5618.2002.01191.x
更新日期：2002-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2006-08-01 00:00:00
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pub_type： 杂志文章,meta分析
doi：10.1111/bdi.12859
更新日期：2020-03-01 00:00:00
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