Abstract:
:Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increasing symptom severity, frequency of episodes and suicide rates, and decreasing response to antidepressant therapy. Anxiety often precedes and hastens the onset of bipolar disorder, and a shared genetic etiology has been suggested. Studies have demonstrated the efficacy of atypical antipsychotics for the acute and maintenance treatment of mania. Evidence from studies in patients with treatment-resistant major depressive disorder and bipolar depression indicate that these agents may also have antidepressant effects. In open trials in patients with bipolar mania, risperidone therapy has led to significant reductions in depression scores compared with baseline. Reductions in depression scores in patients with bipolar mania have been significantly greater with olanzapine compared with placebo. In patients with bipolar depression, the combination of olanzapine and fluoxetine resulted in significant improvement in depression compared with olanzapine alone or placebo. Although little data are available on the effects of these agents on comorbid anxiety in patients with bipolar disorder, some atypical antipsychotics have demonstrated efficacy in patients with anxiety disorders, including obsessive-compulsive disorder, post-traumatic stress disorder, and generalized anxiety disorder. Thus, atypical antipsychotics represent an important therapeutic option for the treatment of bipolar disorder, providing improvements in manic, depressive, and anxiety symptoms.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
McIntyre R,Katzman Mdoi
10.1111/j.1399-2406.2003.00061.xkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
20-35eissn
1398-5647issn
1399-5618journal_volume
5 Suppl 2pub_type
杂志文章,评审abstract:BACKGROUND:Treatment-emergent mania (TEM) represents a common phenomenon inconsistently reported across primary studies, warranting further assessment. METHODS:A systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analysis of Observation...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析
doi:10.1111/bdi.12612
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotiona...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00419.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Recent theories regarding the neuropathology of bipolar disorder suggest that both neurodevelopmental and neurodegenerative processes may play a role. While magnetic resonance imaging has provided significant insight into the structural, functional, and connectivity abnormalities associated with bipolar disor...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2012.01024.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder (BD) is a psychiatric disorder with high morbidity and mortality that cannot be distinguished from major depressive disorder (MDD) until the first manic episode. A biomarker able to differentiate BD and MDD could help clinicians avoid risks of treating BD with antidepressants without mood st...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12175
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To report a case report of a geriatric patient with a 5-year history of gabapentin use for enhanced bipolar control, who was tapered off of gabapentin over 1 week. The patient displayed unique withdrawal symptoms after the taper of gabapentin. METHODS:The patient is an 81-year-old white female with a life-lo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00200.x
更新日期:2005-06-01 00:00:00
abstract:AIMS:To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognit...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12847
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12164
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. METHOD:Data ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2012.01025.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12611
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Bipolar I disorder is a disabling illness affecting 1% of people worldwide. Family and twin studies suggest that psychotic bipolar disorder (BDP) represents a homogeneous subgroup with an etiology distinct from non-psychotic bipolar disorder (BDNP) and partially shared with schizophrenia. Studies of auditory...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12110
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/bdi.12006
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:This study compared the relative risk for hospitalization of patients with bipolar and manic disorders receiving atypical and typical antipsychotics. METHODS:This retrospective study was based on administrative claims data extracted from the PharMetrics database during 1999 through 2003. Comparisons were ma...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00394.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00274.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12595
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post-hoc analysis evaluated the association between obesity and the presen...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/bdi.12519
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate the diagnostic profile of women referred for postpartum depression. METHODS:Fifty-six women seen consecutively with the referral diagnosis of postpartum depression were administered structured instruments to gather information about their DSM-IV Axis I diagnoses. RESULTS:In terms of frequency...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2008.00606.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00173.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine. METHODS:The sample included 164 subjects from 21 families of bipolar probands, 14 responders to lithium and seven to lamotrigine. Diagnostic inform...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章
doi:10.1034/j.1399-5618.2003.00026.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder is associated with positive emotion disturbance, though it is less clear which specific positive emotions are affected. METHODS:The present study examined differences among distinct positive emotions in recovered bipolar disorder (BD) patients (n = 55) and nonclinical controls (NC) (n = 32)...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00679.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/bdi.12594
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Data from several studies suggest that medications, such as ketoconazole, which lower cortisol levels, may be effective for major depressive disorder (MDD). As with MDD, the manic, depressive, and mixed phases of bipolar disorder are frequently associated with elevated cortisol levels. The literature on the ...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2001.030103.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To review research findings on clinical effects of discontinuing lithium maintenance treatment. METHODS:Data from studies reported since 1970 plus our recent findings were updated. RESULTS:Discontinuing lithium maintenance treatment led to marked increases of early affective morbidity and suicidal risk. Gra...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.1999.10106.x
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:The pathophysiological mechanisms underlying bipolar disorder and its multi-system nature are unclear. Oxidatively generated damage to nucleosides has been demonstrated in metabolic disorders; however, the extent to which this occurs in bipolar disorder in vivo is unknown. We investigated oxidatively generat...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12245
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To evaluate frequency and severity of separation anxiety (SA) symptoms, as well as frequency of DSM-IV diagnosis of childhood separation anxiety disorder (CSAD) and adult separation anxiety disorder (ASAD), in a group of patients with bipolar disorder (BD) when compared with patients with panic disorder (PD)...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00216.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5618.2008.00455.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2001.30605.x
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1399-5618.2000.020107.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:Bipolar affective disorder (BPAD) is clinically and genetically heterogeneous and the affected phenotype is poorly defined, hampering studies of its genetic basis. Studies of specific, familial, clinical indicators of BPAD may be useful for identifying heritable forms. Homogeneous forms of the disease may be...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00413.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12517
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Extensive preclinical and clinical evidence suggests mitochondrial dysfunction in bipolar disorder. Studies of brain energy metabolism in bipolar disorder suggest an impairment of energy generation by mitochondrial oxidative phosphorylation. Lithium is an effective drug widely used in treating bipolar disord...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00729.x
更新日期:2009-08-01 00:00:00