Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications.

abstract：OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...

journal_title：Bipolar disorders

authors： Cousins DA,Butts K,Young AH

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD i...

journal_title：Bipolar disorders

authors： Roiser JP,Cannon DM,Gandhi SK,Taylor Tavares J,Erickson K,Wood S,Klaver JM,Clark L,Zarate CA Jr,Sahakian BJ,Drevets WC

更新日期：2009-03-01 00:00:00

abstract：:Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...

journal_title：Bipolar disorders

authors： Savitz J,Solms M,Ramesar R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Suicide is a leading cause of death in the USA. Although factors elevating long-term risk for suicide are known and include bipolar disorder, signs of imminent suicide risk are difficult to study and not well specified. Acute risk determinations must be made to determine the appropriate level of care to safe...

journal_title：Bipolar disorders

authors： Chesin M,Stanley B

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To compare the clinical features and course of major depressive episodes (MDEs) occurring in subjects with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD). METHODS:Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (2001-2002)...

journal_title：Bipolar disorders

authors： Moreno C,Hasin DS,Arango C,Oquendo MA,Vieta E,Liu S,Grant BF,Blanco C

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS:We assessed polarity at onset in patie...

journal_title：Bipolar disorders

authors： Forty L,Jones L,Jones I,Smith DJ,Caesar S,Fraser C,Gordon-Smith K,Hyde S,Craddock N

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Randomized trials of adjunctive psychotherapy for bipolar disorder are reviewed, in tandem with discussion of cost-effectiveness, mediating mechanisms, and moderators of effects. METHODS:Systematic searches of the MEDLINE and PSYCHLIT databases yielded 19 randomized controlled trials of individual family an...

journal_title：Bipolar disorders

authors： Miklowitz DJ,Scott J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:To compare the concentrations of high-energy phosphorus metabolites associated with mitochondrial function in the frontal lobe of depressed adolescents with bipolar disorder (BD) and healthy controls (HC). METHODS:We used in vivo phosphorus-31 magnetic resonance spectroscopy ((31) P-MRS) at 3 Tesla to measu...

journal_title：Bipolar disorders

authors： Shi XF,Kondo DG,Sung YH,Hellem TL,Fiedler KK,Jeong EK,Huber RS,Renshaw PF

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...

journal_title：Bipolar disorders

authors： Kim EY,Miklowitz DJ

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...

journal_title：Bipolar disorders

authors： Conus P,Ward J,Hallam KT,Lucas N,Macneil C,McGorry PD,Berk M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...

journal_title：Bipolar disorders

authors： McKenna BS,Sutherland AN,Legenkaya AP,Eyler LT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Although second-generation antipsychotics (SGAs) are widely used in treating schizophrenia and bipolar disorder, their effects on dyslipidemia, glucose intolerance, metabolic syndrome (MetS), and coronary heart disease (CHD) risk are less well documented for bipolar disorder. We compared bipolar disorder and ...

journal_title：Bipolar disorders

authors： Correll CU,Frederickson AM,Kane JM,Manu P

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

journal_title：Bipolar disorders

authors： Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

更新日期：2014-05-01 00:00:00

abstract：:With great interest, we have read the recent paper by Keramatian and colleagues entitled "Grey Matter Abnormalities in First Episode Mania: A Systematic Review and Meta-analysis of Voxel-Based Morphometry Studies" in Bipolar Disorders1 . The authors systematically reviewed 15 voxel-based morphometry (VBM) studies and ...

journal_title：Bipolar disorders

authors： Sheng L,Ma H,Dai Z,Yao L,Hu J

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...

journal_title：Bipolar disorders

authors： Ferrier IN,Chowdhury R,Thompson JM,Watson S,Young AH

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To investigate the diagnostic profile of women referred for postpartum depression. METHODS:Fifty-six women seen consecutively with the referral diagnosis of postpartum depression were administered structured instruments to gather information about their DSM-IV Axis I diagnoses. RESULTS:In terms of frequency...

journal_title：Bipolar disorders

authors： Sharma V,Khan M,Corpse C,Sharma P

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...

journal_title：Bipolar disorders

authors： Sachs G,Chengappa KN,Suppes T,Mullen JA,Brecher M,Devine NA,Sweitzer DE

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...

journal_title：Bipolar disorders

authors： MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Several lines of evidence suggest that deficits in cognition persist in bipolar patients during periods of euthymia. Working memory impairment has been observed in euthymic bipolar patients and noted to be a significant source of functional deficits in psychiatric disorders. Functional changes associated wit...

journal_title：Bipolar disorders

authors： Adler CM,Holland SK,Schmithorst V,Tuchfarber MJ,Strakowski SM

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...

journal_title：Bipolar disorders

authors： Meyer TD,Crist N,La Rosa N,Ye B,Soares JC,Bauer IE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression. METHODS:Quality of life was assessed using the SF-36 in bipolar patients (n = 958) who had recently experience...

journal_title：Bipolar disorders

authors： Yatham LN,Lecrubier Y,Fieve RR,Davis KH,Harris SD,Krishnan AA

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...

journal_title：Bipolar disorders

authors： Payne JL,MacKinnon DF,Mondimore FM,McInnis MG,Schweizer B,Zamoiski RB,McMahon FJ,Nurnberger JI Jr,Rice JP,Scheftner W,Coryell W,Berrettini WH,Kelsoe JR,Byerley W,Gershon ES,DePaulo JR Jr,Potash JB

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably, the structurally highly dissimilar antimanic agents lithium and valproate, when administered in therapeutically relevant paradigms, attenuate protein kinase C [corre...

journal_title：Bipolar disorders

authors： Zarate CA Jr,Singh JB,Carlson PJ,Quiroz J,Jolkovsky L,Luckenbaugh DA,Manji HK

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) is a common and highly disabling disease characterized by substantial cognitive and functional impairment. The exact neurobiological mechanisms underlying the expression of symptoms in this condition remain unknown but there is growing evidence that glutamate might play an important rol...

journal_title：Bipolar disorders

authors： Gigante AD,Bond DJ,Lafer B,Lam RW,Young LT,Yatham LN

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. METHODS:Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either...

journal_title：Bipolar disorders

authors： Sharma V,Smith A,Mazmanian D

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD). METHODS:Adolescents (n = 80), between the ages of 12 and 21 years (mean = 15.6, standard deviation = 2.3), hospitalized for their initial manic or mixed episode of BD, were ev...

journal_title：Bipolar disorders

authors： Barzman DH,DelBello MP,Fleck DE,Lehmkuhl H,Strakowski SM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:An emerging body of evidence supports a role for dysfunctional purinergic neurotransmission in mood disorders. Adenosine agonists have been shown to have properties similar to those of dopamine antagonists; there is a well-characterized interaction between adenosine and dopamine receptors in the ventral stria...

journal_title：Bipolar disorders

authors： Weiser M,Burshtein S,Gershon AA,Marian G,Vlad N,Grecu IG,Tocari E,Tiugan A,Hotineanu M,Davis JM

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Hypomania in bipolar disorders is characterized by disinhibited, fearless and reward-seeking behavior. This behavioral pattern suggests that early and automatic responding to socio-emotional cues such as facial expressions might be aberrant in hypomania. The present study tested the predictions that particip...

journal_title：Bipolar disorders

authors： Putman P,Saevarsson S,van Honk J

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To report a case report of a geriatric patient with a 5-year history of gabapentin use for enhanced bipolar control, who was tapered off of gabapentin over 1 week. The patient displayed unique withdrawal symptoms after the taper of gabapentin. METHODS:The patient is an 81-year-old white female with a life-lo...

journal_title：Bipolar disorders

authors： Tran KT,Hranicky D,Lark T,Jacob Nj

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...

journal_title：Bipolar disorders

authors： Rodríguez-Cano E,Alonso-Lana S,Sarró S,Fernández-Corcuera P,Goikolea JM,Vieta E,Maristany T,Salvador R,McKenna PJ,Pomarol-Clotet E

更新日期：2017-08-01 00:00:00