Abstract：
OBJECTIVE:Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. METHOD:Data were obtained from 2414 patients with a diagnosis of bipolar I disorder, according to DSM-IV criteria. Data were collected at 24 sites in 13 countries spanning latitudes 6.3 to 63.4 degrees from the equator, including data from both hemispheres. The age of onset and location of onset were obtained retrospectively, from patient records and/or direct interviews. Solar insolation data, or the amount of electromagnetic energy striking the surface of the earth, were obtained from the NASA Surface Meteorology and Solar Energy (SSE) database for each location of onset. RESULTS:The larger the maximum monthly increase in solar insolation at the location of onset, the younger the age of onset (coefficient= -4.724, 95% CI: -8.124 to -1.323, p=0.006), controlling for each country's median age. The maximum monthly increase in solar insolation occurred in springtime. No relationships were found between the age of onset and latitude, yearly total solar insolation, and the maximum monthly decrease in solar insolation. The largest maximum monthly increases in solar insolation occurred in diverse environments, including Norway, arid areas in California, and Chile. CONCLUSION:The large maximum monthly increase in sunlight in springtime may have an important influence on the onset of bipolar disorder.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Bauer M,Glenn T,Alda M,Andreassen OA,Ardau R,Bellivier F,Berk M,Bjella TD,Bossini L,Del Zompo M,Dodd S,Fagiolini A,Frye MA,Gonzalez-Pinto A,Henry C,Kapczinski F,Kliwicki S,König B,Kunz M,Lafer B,Lopez-Jaramillo Cdoi
10.1111/j.1399-5618.2012.01025.xsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
654-63issue
6eissn
1398-5647issn
1399-5618journal_volume
14pub_type
杂志文章abstract：OBJECTIVES:Suicide is a leading cause of death in the USA. Although factors elevating long-term risk for suicide are known and include bipolar disorder, signs of imminent suicide risk are difficult to study and not well specified. Acute risk determinations must be made to determine the appropriate level of care to safe...
journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12092
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Several lines of evidence suggest that deficits in cognition persist in bipolar patients during periods of euthymia. Working memory impairment has been observed in euthymic bipolar patients and noted to be a significant source of functional deficits in psychiatric disorders. Functional changes associated wit...
journal_title：Bipolar disorders
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/bdi.12202
更新日期：2014-06-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1034/j.1399-5618.2003.00055.x
更新日期：2003-10-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12247
更新日期：2014-12-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2005.00254.x
更新日期：2005-01-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1034/j.1399-5618.2002.01226.x
更新日期：2002-10-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1046/j.1399-5618.2003.00087.x
更新日期：2004-02-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章,评审
doi：10.1111/j.1399-5618.2005.00203.x
更新日期：2005-06-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1399-5618.2007.00343.x
更新日期：2007-02-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2006.00281.x
更新日期：2006-04-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2009.00788.x
更新日期：2010-02-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12954
更新日期：2020-06-10 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2009.00744.x
更新日期：2009-11-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章,评审
doi：10.1111/j.1399-5618.2012.01024.x
更新日期：2012-06-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12771
更新日期：2019-09-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12453
更新日期：2016-12-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1399-5618.2000.020107.x
更新日期：2000-03-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12385
更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2005.00200.x
更新日期：2005-06-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2008.00654.x
更新日期：2009-02-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2010.00855.x
更新日期：2010-09-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/bdi.12245
更新日期：2015-05-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章,评审
doi：10.1034/j.1399-5618.2001.30605.x
更新日期：2001-12-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1034/j.1399-5618.1999.10106.x
更新日期：1999-09-01 00:00:00
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journal_title：Bipolar disorders
pub_type： 杂志文章
doi：10.1111/j.1399-5618.2011.00936.x
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:To develop a cognitive behavioral intervention for adolescents with bipolar disorders, test its feasibility and preliminary efficacy. METHODS:Based on existing research, a manualized, individually delivered cognitive behavioral intervention was developed and tested with adolescents with bipolar disorders as...
journal_title：Bipolar disorders
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1399-5618.2006.00358.x
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...
journal_title：Bipolar disorders
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1399-5618.2008.00455.x
更新日期：2008-02-01 00:00:00
