Abstract:
OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written informed consent forms, which were reread up to three times. Questions included assessment of hypothetical study purposes, procedures, risks and benefits, and voluntariness of participation. RESULTS:After adjusting for educational level, subjects with mania had lower mean understanding scores for all three hypothetical studies compared to euthymic subjects on initial assessment. By the end of Trial 3 of each hypothetical study, there were no significant differences between groups. The proportion of subjects with mania who met predetermined pass criteria for sufficient understanding was lower than the proportion of euthymic subjects on initial assessment of the first hypothetical study, but not the other hypothetical studies (odds ratio = 0.24; 95% confidence interval = 0.07-0.8; p = 0.02). Both groups exhibited an increase in the pass proportion by the end of the third trial for each hypothetical study with no significant differences between groups. CONCLUSIONS:We conclude that subjects with mania exhibited significantly poorer levels of understanding of relevant information in hypothetical research consent forms compared to euthymic subjects when initially presented with research information. The improvement in manic patients' understanding scores with the iterative review of consent forms suggests that many manic patients may be able to consent to research protocols containing an educational intervention as a part of the informed consent process.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Misra S,Socherman R,Park BS,Hauser P,Ganzini Ldoi
10.1111/j.1399-5618.2007.00525.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
303-9issue
2eissn
1398-5647issn
1399-5618pii
BDI525journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Bipolar illness is frequently misdiagnosed. Several studies have focused on the underdiagnosis of this condition and the frequent long delay in its recognition. However, the illness is difficult to diagnose and many of its symptoms are shared by other conditions. In order to determine the accuracy of the dia...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00465.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12126
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/bdi.12006
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:There is wide recognition that symptom ratings alone are inadequate to measure outcomes in bipolar disorder (BD), and quality of life (QoL) has been proposed as an important separable construct. Although a literature on QoL in BD exists, there is no disorder-specific measure of QoL in BD. In 2004, we embarke...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00865.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the ingested dose, previous treatment duration and renal function. Whether the severity of lithium-induced encephalopathy depends on the poisoning pattern has not be...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12482
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12595
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00906.x
更新日期:2011-03-01 00:00:00
abstract::Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.020204.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotiona...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00419.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12625
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12105
更新日期:2013-09-01 00:00:00
abstract::Research into postnatal mood disorders to date has concentrated on depressive syndromes of varying severity and full-blown acute puerperal mania. However, clinical experience, backed up by a review of the literature, indicates that milder hypomanic symptoms also occur in the early puerperium. Although these symptoms m...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2005.00185.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The notion that sufferers of bipolar disorder achieve complete syndromal and functional recovery between illness episodes has been brought into question by evidence that a large proportion of patients fail to regain premorbid levels of functioning after the resolution of major affective symptoms. A growing b...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1399-5618.2006.00277.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably, the structurally highly dissimilar antimanic agents lithium and valproate, when administered in therapeutically relevant paradigms, attenuate protein kinase C [corre...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2007.00530.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear. METHODS:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suic...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00744.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To examine the nature of executive deficits in euthymic patients with bipolar disorder (BD). METHODS:Fifteen euthymic BD patients and 13 controls were administered a battery of executive tasks including verbal fluency, Stroop, Theory of Mind (ToM) tests and selected subtests from the Cambridge Neuropsycholo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00254.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:The study was designed to test an audit-based quality improvement programme (QIP) addressing lithium prescribing and monitoring in UK mental health services. METHODS:A baseline clinical audit was conducted against the following standards: (i) measurement of renal and thyroid function before initiating treat...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12128
更新日期:2013-12-01 00:00:00
abstract::With great interest, we have read the recent paper by Keramatian and colleagues entitled "Grey Matter Abnormalities in First Episode Mania: A Systematic Review and Meta-analysis of Voxel-Based Morphometry Studies" in Bipolar Disorders1 . The authors systematically reviewed 15 voxel-based morphometry (VBM) studies and ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.13048
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVE:To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression. METHODS:Quality of life was assessed using the SF-36 in bipolar patients (n = 958) who had recently experience...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00134.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00281.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:Bipolar major depression differs considerably from unipolar major depression with regard to the efficacy of treatment with antidepressants. In bipolar depression, response to treatment with antidepressants is disappointing. Whether response to electroconvulsive therapy (ECT) differs between bipolar and unipol...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1399-5618.2012.00997.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:An emerging body of evidence supports a role for dysfunctional purinergic neurotransmission in mood disorders. Adenosine agonists have been shown to have properties similar to those of dopamine antagonists; there is a well-characterized interaction between adenosine and dopamine receptors in the ventral stria...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bdi.12202
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:Dopamine transmission abnormalities have been implicated in the etiology of bipolar disorder (BPD). However, there is a paucity of receptor imaging studies in BPD, and little information is available about the dopamine system in BPD. Reuptake of synaptic dopamine by the dopamine transporter (DAT) is the prin...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00936.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01226.x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Topiramate, a newer antiepileptic agent, may benefit several neurological and psychiatric states, including bipolar disorder. CASE REPORT:A physically healthy, stockily built, 47-year-old, hypomanic Asian male with a >20-year history of uneventful use of psychotropic agents received topiramate in a dose tha...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To identify the risk factors for suicidal ideation in subjects with bipolar depression. METHODS:One-hundred and thirty subjects diagnosed with bipolar depression were evaluated on the following scales: Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Patient Health Questionnaire-15 (PHQ-15), B...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12179
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00267.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00164.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of the dopaminergic-enhancing agent modafinil/armodafinil (MoArm) as adjunctive treatment for bipolar depression. METHODS:A comprehensive search of major electronic databases was conducted to identify randomized controlled trials (RCTs) of adjunct...
journal_title:Bipolar disorders
pub_type: 杂志文章,meta分析
doi:10.1111/bdi.12859
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume o...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12526
更新日期:2017-09-01 00:00:00