Postnatal euphoria: are 'the highs' an indicator of bipolarity?

abstract：OBJECTIVES:Suicide is a leading cause of death in the USA. Although factors elevating long-term risk for suicide are known and include bipolar disorder, signs of imminent suicide risk are difficult to study and not well specified. Acute risk determinations must be made to determine the appropriate level of care to safe...

journal_title：Bipolar disorders

authors： Chesin M,Stanley B

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date. OBJECTIVES:To estimate...

journal_title：Bipolar disorders

authors： Holtmann M,Bölte S,Goth K,Döpfner M,Plück J,Huss M,Fegert JM,Lehmkuhl G,Schmeck K,Poustka F

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. METHOD:Data ...

journal_title：Bipolar disorders

authors： Bauer M,Glenn T,Alda M,Andreassen OA,Ardau R,Bellivier F,Berk M,Bjella TD,Bossini L,Del Zompo M,Dodd S,Fagiolini A,Frye MA,Gonzalez-Pinto A,Henry C,Kapczinski F,Kliwicki S,König B,Kunz M,Lafer B,Lopez-Jaramillo C

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...

journal_title：Bipolar disorders

authors： MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:There is wide recognition that symptom ratings alone are inadequate to measure outcomes in bipolar disorder (BD), and quality of life (QoL) has been proposed as an important separable construct. Although a literature on QoL in BD exists, there is no disorder-specific measure of QoL in BD. In 2004, we embarke...

journal_title：Bipolar disorders

authors： Michalak EE,Murray G,Collaborative RESearch Team to Study Psychosocial Issues in Bipolar Disorder (CREST.BD).

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...

journal_title：Bipolar disorders

authors： Escamilla MA

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...

journal_title：Bipolar disorders

authors： Kamath V,Paksarian D,Cui L,Moberg PJ,Turetsky BI,Merikangas KR

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Approximate entropy (ApEn) measures regularity in time series data, while traditional linear statistics measure variability. Using self-reported mood data from patients with bipolar disorder, this preliminary study addressed whether ApEn could distinguish (i) the 60 days prior to the start of a manic or depr...

journal_title：Bipolar disorders

authors： Glenn T,Whybrow PC,Rasgon N,Grof P,Alda M,Baethge C,Bauer M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:The enzyme glycogen synthase kinase-3β (GSK3β) is involved in the mechanisms of action of lithium and may play a role in relation to affective states in bipolar disorder. The objectives of the present study were to compare the activity of GSK-3β (measured as levels of phosphorylated GSK-3β [p-GSK-3β]) betwee...

journal_title：Bipolar disorders

authors： Jacoby AS,Munkholm K,Vinberg M,Joaquim HG,Talib LL,Gattaz WF,Kessing LV

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Pediatric bipolar disorder is currently diagnosed based on signs and symptoms, and without objective diagnostic biomarkers. In the present study, we investigated the utility of structural neuroanatomical signatures of the amygdala to objectively differentiate individual subjects with pediatric bipolar disord...

journal_title：Bipolar disorders

authors： Mwangi B,Spiker D,Zunta-Soares GB,Soares JC

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...

journal_title：Bipolar disorders

authors： Misra S,Socherman R,Park BS,Hauser P,Ganzini L

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Recent theories regarding the neuropathology of bipolar disorder suggest that both neurodevelopmental and neurodegenerative processes may play a role. While magnetic resonance imaging has provided significant insight into the structural, functional, and connectivity abnormalities associated with bipolar disor...

journal_title：Bipolar disorders

authors： Schneider MR,DelBello MP,McNamara RK,Strakowski SM,Adler CM

更新日期：2012-06-01 00:00:00

abstract：:Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

journal_title：Bipolar disorders

authors： Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:To investigate the use of transcranial direct current stimulation (tDCS) for enhancing working memory and sustained attention in euthymic patients with bipolar disorder. METHODS:Fifteen patients with bipolar disorder received anodal left prefrontal tDCS with an extracephalic cathode (prefrontal condition), ...

journal_title：Bipolar disorders

authors： Martin DM,Chan HN,Alonzo A,Green MJ,Mitchell PB,Loo CK

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the interven...

journal_title：Bipolar disorders

authors： Perlick DA,Jackson C,Grier S,Huntington B,Aronson A,Luo X,Miklowitz DJ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Neurovascular abnormalities are relevant to the pathophysiology of bipolar disorder (BD), which can be assessed using cerebral blood flow (CBF) imaging. CBF alterations have been identified in BD, but studies to date have been small and inconclusive. We aimed to determine cortical gray matter CBF (GM-CBF) di...

journal_title：Bipolar disorders

authors： Zeng V,Lizano P,Bolo NR,Lutz O,Brady R Jr,Ivleva EI,Dai W,Clementz B,Tamminga C,Pearlson G,Keshavan M

更新日期：2020-06-24 00:00:00

abstract：OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...

journal_title：Bipolar disorders

authors： Conus P,Ward J,Hallam KT,Lucas N,Macneil C,McGorry PD,Berk M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:The pathophysiological mechanisms underlying bipolar disorder and its multi-system nature are unclear. Oxidatively generated damage to nucleosides has been demonstrated in metabolic disorders; however, the extent to which this occurs in bipolar disorder in vivo is unknown. We investigated oxidatively generat...

journal_title：Bipolar disorders

authors： Munkholm K,Poulsen HE,Kessing LV,Vinberg M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume o...

journal_title：Bipolar disorders

authors： Tréhout M,Leroux E,Delcroix N,Dollfus S

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...

journal_title：Bipolar disorders

authors： Sachs G,Chengappa KN,Suppes T,Mullen JA,Brecher M,Devine NA,Sweitzer DE

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...

journal_title：Bipolar disorders

authors： Meyer TD,Crist N,La Rosa N,Ye B,Soares JC,Bauer IE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:To develop a cognitive behavioral intervention for adolescents with bipolar disorders, test its feasibility and preliminary efficacy. METHODS:Based on existing research, a manualized, individually delivered cognitive behavioral intervention was developed and tested with adolescents with bipolar disorders as...

journal_title：Bipolar disorders

authors： Feeny NC,Danielson CK,Schwartz L,Youngstrom EA,Findling RL

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To identify the risk factors for suicidal ideation in subjects with bipolar depression. METHODS:One-hundred and thirty subjects diagnosed with bipolar depression were evaluated on the following scales: Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Patient Health Questionnaire-15 (PHQ-15), B...

journal_title：Bipolar disorders

authors： Umamaheswari V,Avasthi A,Grover S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

journal_title：Bipolar disorders

authors： Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonan...

journal_title：Bipolar disorders

authors： Frey BN,Stanley JA,Nery FG,Monkul ES,Nicoletti MA,Chen HH,Hatch JP,Caetano SC,Ortiz O,Kapczinski F,Soares JC

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably, the structurally highly dissimilar antimanic agents lithium and valproate, when administered in therapeutically relevant paradigms, attenuate protein kinase C [corre...

journal_title：Bipolar disorders

authors： Zarate CA Jr,Singh JB,Carlson PJ,Quiroz J,Jolkovsky L,Luckenbaugh DA,Manji HK

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...

journal_title：Bipolar disorders

authors： Rodríguez-Cano E,Alonso-Lana S,Sarró S,Fernández-Corcuera P,Goikolea JM,Vieta E,Maristany T,Salvador R,McKenna PJ,Pomarol-Clotet E

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:A high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of a...

journal_title：Bipolar disorders

authors： Chang YH,Lee SY,Wang TY,Chen SL,Tzeng NS,Chen PS,Lee IH,Chen KC,Huang SY,Yang YK,Ko HC,Lu RB

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Patients experiencing an acute mood episode of bipolar disorder are impaired on cognitive tests of executive functioning when compared with healthy subjects. However, it is unclear to what extent executive dysfunction exists (i) during syndromal remission, when mood symptoms are attenuated, and (ii) during t...

journal_title：Bipolar disorders

authors： Fleck DE,Shear PK,Madore M,Strakowski SM

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Objective physiological indices independently characterizing affective and schizophreniform psychoses would contribute to our understanding of the nature of their relationships. Magnetoencephalography (MEG)-based metrics of altered structural/functional asymmetry in the superior temporal gyrus have previousl...

journal_title：Bipolar disorders

authors： Reite M,Teale P,Rojas DC,Reite E,Asherin R,Hernandez O

更新日期：2009-06-01 00:00:00