Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania.

abstract：BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...

journal_title：Malaria journal

authors： Grande R,Antinori S,Meroni L,Menegon M,Severini C

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Mice with genetic deficiencies in adaptive immunity are used for the grafting of human cells or pathogens, to study human diseases, however, the innate immune responses to xenografts in these mice has received little attention. Using the NOD/SCID Plasmodium falciparum mouse model an analysis of innate defenc...

journal_title：Malaria journal

authors： Arnold L,Tyagi RK,Mejia P,Van Rooijen N,Pérignon JL,Druilhe P

更新日期：2010-07-09 00:00:00

abstract：INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...

journal_title：Malaria journal

authors： Magesa SM,Lengeler C,deSavigny D,Miller JE,Njau RJ,Kramer K,Kitua A,Mwita A

更新日期：2005-07-22 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Obtaining single parasite clones is required for many techniques in malaria research. Cloning by limiting dilution using microscopy-based assessment for parasite growth is an arduous and labor-intensive process. An alternative method for the detection of parasite growth in limiting dilution assays is using a...

journal_title：Malaria journal

authors： Butterworth AS,Robertson AJ,Ho MF,Gatton ML,McCarthy JS,Trenholme KR

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

journal_title：Malaria journal

authors： Fu Y,Ding Y,Zhou T,Fu X,Xu W

更新日期：2012-04-01 00:00:00

abstract：:April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness, to review progress and renew commitments. After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in...

journal_title：Malaria journal

authors： Slutsker L,Kachur SP

更新日期：2013-04-24 00:00:00

abstract：BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...

journal_title：Malaria journal

authors： Zou X,House BL,Zyzak MD,Richie TL,Gerbasi VR

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated with artemisinin resistance, and pfmdr1, associated with lumefantrine resistance, have not been s...

journal_title：Malaria journal

authors： Ljolje D,Dimbu PR,Kelley J,Goldman I,Nace D,Macaia A,Halsey ES,Ringwald P,Fortes F,Udhayakumar V,Talundzic E,Lucchi NW,Plucinski MM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. METHODS:Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quan...

journal_title：Malaria journal

authors： Kakande E,Greenhouse B,Bajunirwe F,Drakeley C,Nankabirwa JI,Walakira A,Nsobya SL,Katureebe A,Rek J,Arinaitwe E,Rosenthal PJ,Kamya MR,Dorsey G,Rodriguez-Barraquer I

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...

journal_title：Malaria journal

authors： Ezenduka CC,Ogbonna BO,Ekwunife OI,Okonta MJ,Esimone CO

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00

abstract：:This article reports the changing pattern of US President's Malaria Initiative-funded IRS in sub-Saharan Africa between 2008 and 2015. IRS coverage in sub-Saharan Africa increased from <2 % of the at-risk population in 2005, to 11 % or 78 million people in 2010, mainly as a result of increased funding from PMI. The sc...

journal_title：Malaria journal

authors： Oxborough RM

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:Malaria in Southeast Asia frequently clusters along international borders. For example, while most of Thailand is malaria free, the border region shared with Myanmar continues to have endemic malaria. This spatial pattern is the result of complex interactions between landscape, humans, mosquito vectors, and ...

journal_title：Malaria journal

authors： Parker DM,Carrara VI,Pukrittayakamee S,McGready R,Nosten FH

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...

journal_title：Malaria journal

authors： Mens PF,Moers AP,de Bes LM,Flint J,Sak JR,Keereecharoen L,van Overmeir C,Verweij JJ,Hallett RL,Wihokhoen B,Proux S,Schallig HD,van Amerongen A

更新日期：2012-08-17 00:00:00

abstract：:Malaria currently causes more harm to human beings than any other parasitic disease, and disproportionally affects low-income populations. The ethical issues raised by efforts to control or eliminate malaria have received little explicit analysis, in comparison with other major diseases of poverty. While some ethical ...

journal_title：Malaria journal

authors： Jamrozik E,de la Fuente-Núñez V,Reis A,Ringwald P,Selgelid MJ

更新日期：2015-12-22 00:00:00

abstract：:The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facility records to evaluate the impact of malaria control efforts in Rwanda and Ethiopia. Although the authors dem...

journal_title：Malaria journal

authors： Rowe AK,Kachur SP,Yoon SS,Lynch M,Slutsker L,Steketee RW

更新日期：2009-09-03 00:00:00

abstract：BACKGROUND:Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected people in the area and to identify the factors influencing malaria transmission. METHODS:Demograph...

journal_title：Malaria journal

authors： Sérandour J,Girel J,Boyer S,Ravanel P,Lemperière G,Raveton M

更新日期：2007-08-29 00:00:00

abstract：BACKGROUND:The current status of insecticide resistance and the underlying resistance mechanisms were studied in the major vector of malaria, Anopheles culicifacies, and the secondary vector, Anopheles subpictus in five districts (Anuradhapura, Kurunegala, Moneragala, Puttalam and Trincomalee) of Sri Lanka. Eight other...

journal_title：Malaria journal

authors： Perera MD,Hemingway J,Karunaratne SP

更新日期：2008-08-28 00:00:00

abstract：BACKGROUND:Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality ...

journal_title：Malaria journal

authors： Yasuoka J,Poudel KC,Poudel-Tandukar K,Nguon C,Ly P,Socheat D,Jimba M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current study was to assess access to Kenya's policy recommended anti-malarials, ACT and quinine i...

journal_title：Malaria journal

authors： Watsierah CA,Ouma C

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Deltamethrin-impregnated, long-lasting insecticidal nets (LLINs) were distributed in the study area from November 2014 to January 2015 to evaluate their impact on malaria transmission in the presence of insecticide-resistant vectors. Studies were carried out in 16 selected clusters in Keshkal sub-district, C...

journal_title：Malaria journal

authors： Kona MP,Kamaraju R,Donnelly MJ,Bhatt RM,Nanda N,Chourasia MK,Swain DK,Suman S,Uragayala S,Kleinschmidt I,Pandey V

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:As malaria transmission declines, it becomes more geographically focused and more likely due to asymptomatic and non-falciparum infections. To inform malaria elimination planning in the context of this changing epidemiology, local assessments on the risk factors for malaria infection are necessary, yet chall...

journal_title：Malaria journal

authors： Herdiana H,Cotter C,Coutrier FN,Zarlinda I,Zelman BW,Tirta YK,Greenhouse B,Gosling RD,Baker P,Whittaker M,Hsiang MS

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...

journal_title：Malaria journal

authors： Horton AA,Lee Y,Coulibaly CA,Rashbrook VK,Cornel AJ,Lanzaro GC,Luckhart S

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Interest in the use of fungal entomopathogens against malaria vectors is growing. Fungal spores infect insects via the cuticle and can be applied directly on the insect to evaluate infectivity. For flying insects such as mosquitoes, however, application of fungal suspensions on resting surfaces is more reali...

journal_title：Malaria journal

authors： Farenhorst M,Knols BG

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for trea...

journal_title：Malaria journal

authors： Sutherland CJ,Laundy M,Price N,Burke M,Fivelman QL,Pasvol G,Klein JL,Chiodini PL

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (PfCSP) is one of the most extensively studied malaria vaccine candidates, but the genetic polymorphism of PfCSP within and among the global P. falciparum population raises concerns regarding the efficacy of a PfCSP-based vaccine efficacy. In this study, genetic...

journal_title：Malaria journal

authors： Lê HG,Kang JM,Moe M,Jun H,Thái TL,Lee J,Myint MK,Lin K,Sohn WM,Shin HJ,Kim TS,Na BK

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:T1BT* is a peptide construct containing the T1 and B epitopes located in the 5' minor repeat and the 3' major repeat of the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP), respectively, and the universal T* epitope located in the C-terminus of the same protein. This peptide...

journal_title：Malaria journal

authors： Topchiy E,Armstrong GS,Boswell KI,Buchner GS,Kubelka J,Lehmann TE

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...

journal_title：Malaria journal

authors： Mwangangi JM,Shililu J,Muturi EJ,Muriu S,Jacob B,Kabiru EW,Mbogo CM,Githure J,Novak RJ

更新日期：2010-08-09 00:00:00

abstract：:Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...

journal_title：Malaria journal

authors： Morris CA,Duparc S,Borghini-Fuhrer I,Jung D,Shin CS,Fleckenstein L

更新日期：2011-09-13 00:00:00