Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania.

abstract：BACKGROUND:Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown. Over time, children in endemic areas acquire non-sterile immunity to malaria that correlates with development of antibodies to merozoite invasion proteins and pa...

journal_title：Malaria journal

authors： Kessler A,Campo JJ,Harawa V,Mandala WL,Rogerson SJ,Mowrey WB,Seydel KB,Kim K

更新日期：2018-04-25 00:00:00

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Cerebral malaria (CM) is associated with morbidity and mortality despite the use of potent anti-malarial agents. Brain endothelial cell activation and dysfunction from oxidative and inflammatory host responses and products released by Plasmodium falciparum-infected erythrocytes (IE), are likely the major con...

journal_title：Malaria journal

authors： Mita-Mendoza NK,Magallon-Tejada A,Parmar P,Furtado R,Aldrich M,Saidi A,Taylor T,Smith J,Seydel K,Daily JP

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...

journal_title：Malaria journal

authors： Horton AA,Lee Y,Coulibaly CA,Rashbrook VK,Cornel AJ,Lanzaro GC,Luckhart S

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Rapid diagnosis and correct treatment of cases are the main objectives of control programs in malaria-endemic areas. METHODS AND RESULTS:To evaluate these criteria and in a comparative study, blood specimens were collected from 120 volunteers seeking care at the Malaria Health Center in Chahbahar district. ...

journal_title：Malaria journal

authors： Zakeri S,Najafabadi ST,Zare A,Djadid ND

更新日期：2002-02-08 00:00:00

abstract：BACKGROUND:The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include outdoor biting, sub-optimal implementation and inappropriate use. New vector control interventions are required and ...

journal_title：Malaria journal

authors： Makungu C,Stephen S,Kumburu S,Govella NJ,Dongus S,Hildon ZJ,Killeen GF,Jones C

更新日期：2017-10-11 00:00:00

abstract：:The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as continuous surfaces using model-based geostatistical methods. The opportunities and limitations of these mapped o...

journal_title：Malaria journal

authors： Howes RE,Hawa K,Andriamamonjy VF,Franchard T,Miarimbola R,Mioramalala SA,Rafamatanantsoa JF,Rahantamalala MAM,Rajaobary SH,Rajaonera HDG,Rakotonindrainy AP,Rakotoson Andrianjatonavalona C,Randriamiarinjatovo DNAL,Randrianasolo

更新日期：2019-03-22 00:00:00

abstract：BACKGROUND:The malaria parasite disposes of host-derived ferrihaem (iron(III)protoporphyrin IX, Fe(III)PPIX) by conversion to crystalline haemozoin in close association with neutral lipids. Lipids mediate synthetic haemozoin (β-haematin) formation very efficiently. However, the effect on reaction rates of concentration...

journal_title：Malaria journal

authors： Ambele MA,Egan TJ

更新日期：2012-10-08 00:00:00

abstract：:The substantial impact of cross-border collaborative control efforts on the burden of malaria in southern Africa has previously been demonstrated through the successes of the Lubombo Spatial Development Initiative. Increases in malaria cases recorded in the three partner countries (Mozambique, South Africa, Swaziland)...

journal_title：Malaria journal

authors： Moonasar D,Maharaj R,Kunene S,Candrinho B,Saute F,Ntshalintshali N,Morris N

更新日期：2016-08-18 00:00:00

abstract：BACKGROUND:Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, the drug resistance profile of current and previous first-line anti-malarials in Kenya was assessed w...

journal_title：Malaria journal

authors： Shah M,Omosun Y,Lal A,Odero C,Gatei W,Otieno K,Gimnig JE,ter Kuile F,Hawley WA,Nahlen B,Kariuki S,Walker E,Slutsker L,Hamel M,Shi YP

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...

journal_title：Malaria journal

authors： Mikkelsen-Lopez I,Shango W,Barrington J,Ziegler R,Smith T,deSavigny D

更新日期：2014-05-11 00:00:00

abstract：BACKGROUND:There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in vitro. However, they are inflammatory and alter the permeability of the blood-brain barrier, rai...

journal_title：Malaria journal

authors： Recuenco FC,Takano R,Chiba S,Sugi T,Takemae H,Murakoshi F,Ishiwa A,Inomata A,Horimoto T,Kobayashi Y,Horiuchi N,Kato K

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...

journal_title：Malaria journal

authors： González C,Molina AG,León C,Salcedo N,Rondón S,Paz A,Atencia MC,Tovar C,Ortiz M

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vac...

journal_title：Malaria journal

authors： Aka KG,Traoré DF,Sagna AB,Zoh DD,Assi SB,Tchiekoi BN,Adja AM,Remoue F,Poinsignon A

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...

journal_title：Malaria journal

authors： Ishengoma DS,Lwitiho S,Madebe RA,Nyagonde N,Persson O,Vestergaard LS,Bygbjerg IC,Lemnge MM,Alifrangis M

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. The aim of this study was to assess the diagnostic performance of salivary urea nitrogen (SUN) dipst...

journal_title：Malaria journal

authors： Calice-Silva V,Sacomboio E,Raimann JG,Evans R,Dos Santos Sebastião C,Tchivango AT,Kotanko P,Levin N,Pecoits-Filho R

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...

journal_title：Malaria journal

authors： Culleton RL,Mita T,Ndounga M,Unger H,Cravo PV,Paganotti GM,Takahashi N,Kaneko A,Eto H,Tinto H,Karema C,D'Alessandro U,do Rosário V,Kobayakawa T,Ntoumi F,Carter R,Tanabe K

更新日期：2008-09-11 00:00:00

abstract：BACKGROUND:This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. METHODS:Between December 2007 ...

journal_title：Malaria journal

authors： Damien GB,Djènontin A,Rogier C,Corbel V,Bangana SB,Chandre F,Akogbéto M,Kindé-Gazard D,Massougbodji A,Henry MC

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...

journal_title：Malaria journal

authors： Haque U,Magalhães RJ,Reid HL,Clements AC,Ahmed SM,Islam A,Yamamoto T,Haque R,Glass GE

更新日期：2010-05-09 00:00:00

abstract：:The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and...

journal_title：Malaria journal

authors： Thriemer K,Bobogare A,Ley B,Gudo CS,Alam MS,Anstey NM,Ashley E,Baird JK,Gryseels C,Jambert E,Lacerda M,Laihad F,Marfurt J,Pasaribu AP,Poespoprodjo JR,Sutanto I,Taylor WR,van den Boogaard C,Battle KE,Dysoley L,Ghim

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relativ...

journal_title：Malaria journal

authors： Olupot-Olupot P,Eregu EIE,Naizuli K,Ikiror J,Acom L,Burgoine K

更新日期：2018-04-20 00:00:00

abstract：BACKGROUND:Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8+ T cells targeting liver stage antigens can mediate sterile protection. T...

journal_title：Malaria journal

authors： Schwenk R,Banania G,Epstein J,Kim Y,Peters B,Belmonte M,Ganeshan H,Huang J,Reyes S,Stryhn A,Ockenhouse CF,Buus S,Richie TL,Sedegah M

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...

journal_title：Malaria journal

authors： Kusi KA,Bosomprah S,Dodoo D,Kyei-Baafour E,Dickson EK,Mensah D,Angov E,Dutta S,Sedegah M,Koram KA

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...

journal_title：Malaria journal

authors： Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué F

更新日期：2012-03-16 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...

journal_title：Malaria journal

authors： Kozycki CT,Umulisa N,Rulisa S,Mwikarago EI,Musabyimana JP,Habimana JP,Karema C,Krogstad DJ

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...

journal_title：Malaria journal

authors： Ezenduka CC,Ogbonna BO,Ekwunife OI,Okonta MJ,Esimone CO

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:The close relationship between vector-borne diseases and their environment is well documented, especially for diseases with water-dependent vectors such as avian malaria. Mosquitoes are the primary vectors of avian malaria and also the definitive hosts in the disease life cycle. Factors pertinent to mosquito...

journal_title：Malaria journal

authors： Okanga S,Cumming GS,Hockey PA

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Malaria transmission is complex and is believed to be associated with local climate changes. However, simple attempts to extrapolate malaria incidence rates from averaged regional meteorological conditions have proven unsuccessful. Therefore, the objective of this study was to determine if variations in spec...

journal_title：Malaria journal

authors： Loha E,Lindtjørn B

更新日期：2010-06-16 00:00:00

abstract：BACKGROUND:Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in...

journal_title：Malaria journal

authors： Choowongkomon K,Theppabutr S,Songtawee N,Day NP,White NJ,Woodrow CJ,Imwong M

更新日期：2010-03-02 00:00:00