T1BT* structural study of an anti-plasmodial peptide through NMR and molecular dynamics.

abstract：BACKGROUND:Knowledge of the ecology and behaviour of a target species is a prerequisite for the successful development of any vector control strategy. Before the implementation of any strategy it is essential to have comprehensive information on the bionomics of species in the targeted area. The aims of this study were...

journal_title：Malaria journal

authors： Munhenga G,Brooke BD,Spillings B,Essop L,Hunt RH,Midzi S,Govender D,Braack L,Koekemoer LL

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Prompt and correct diagnosis of malaria is crucial for accurate epidemiological assessment and better case management, and while the gold standard of light microscopy is often available, it requires both expertise and time. Portable fluorescent microscopy using the CyScope offers a potentially quicker, easie...

journal_title：Malaria journal

authors： Sousa-Figueiredo JC,Oguttu D,Adriko M,Besigye F,Nankasi A,Arinaitwe M,Namukuta A,Betson M,Kabatereine NB,Stothard JR

更新日期：2010-08-27 00:00:00

abstract：BACKGROUND:Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is undermining the sustainability of these control strategies. Alternatives to the currently available co...

journal_title：Malaria journal

authors： Kikankie CK,Brooke BD,Knols BG,Koekemoer LL,Farenhorst M,Hunt RH,Thomas MB,Coetzee M

更新日期：2010-03-08 00:00:00

abstract：BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock o...

journal_title：Malaria journal

authors： Mayagaya VS,Nkwengulila G,Lyimo IN,Kihonda J,Mtambala H,Ngonyani H,Russell TL,Ferguson HM

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:The importance of net durability and the average useful life of a net is increasingly recognized as one of the critical factors that determine how often nets need to be replaced. A study to assess the effect of a net care and repair behaviour change communication (BCC) programme on net durability was conduct...

journal_title：Malaria journal

authors： Helinski MH,Namara G,Koenker H,Kilian A,Hunter G,Acosta A,Scandurra L,Selby RA,Mulondo K,Fotheringham M,Lynch M

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...

journal_title：Malaria journal

authors： Ménard D,Andrianina NN,Ramiandrasoa Z,Randriamanantena A,Rasoarilalao N,Jahevitra M,Ratsimbasoa A,Tuseo L,Raveloson A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality ...

journal_title：Malaria journal

authors： Yasuoka J,Poudel KC,Poudel-Tandukar K,Nguon C,Ly P,Socheat D,Jimba M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the public, providing many novel chemical starting points for anti-malarial drug disco...

journal_title：Malaria journal

authors： Le Manach C,Scheurer C,Sax S,Schleiferböck S,Cabrera DG,Younis Y,Paquet T,Street L,Smith P,Ding XC,Waterson D,Witty MJ,Leroy D,Chibale K,Wittlin S

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years. Malaria caused by Plasmodium vivax has recently shown resistance to chloroquine in some places. This study compared the efficacy and safety of fixed dose combination (FDC) of arterolane maleate and piperaquine phosph...

journal_title：Malaria journal

authors： Valecha N,Savargaonkar D,Srivastava B,Rao BH,Tripathi SK,Gogtay N,Kochar SK,Kumar NB,Rajadhyaksha GC,Lakhani JD,Solanki BB,Jalali RK,Arora S,Roy A,Saha N,Iyer SS,Sharma P,Anvikar AR

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Post-malaria neurological syndrome (PMNS) is a debated entity, defined by neurological complications following a post-malaria symptom-free period and a negative blood smear. Four cases of PMNS are hereby reported and a review the literature performed to clarify the nosological framework of this syndrome. ME...

journal_title：Malaria journal

authors： Tamzali Y,Demeret S,Haddad E,Guillot H,Caumes E,Jauréguiberry S

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...

journal_title：Malaria journal

authors： Horton AA,Lee Y,Coulibaly CA,Rashbrook VK,Cornel AJ,Lanzaro GC,Luckhart S

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor transmission of malaria, particularly am...

journal_title：Malaria journal

authors： Crawshaw AF,Maung TM,Shafique M,Sint N,Nicholas S,Li MS,Roca-Feltrer A,Hii J

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...

journal_title：Malaria journal

authors： Chanthap L,Ariey F,Socheat D,Tsuyuoka R,Bell D

更新日期：2010-01-23 00:00:00

abstract：BACKGROUND:In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of mal...

journal_title：Malaria journal

authors： Ademolue TW,Aniweh Y,Kusi KA,Awandare GA

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample is to be obtained. Furthermo...

journal_title：Malaria journal

authors： Cham GK,Kurtis J,Lusingu J,Theander TG,Jensen AT,Turner L

更新日期：2008-06-12 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...

journal_title：Malaria journal

authors： Kozycki CT,Umulisa N,Rulisa S,Mwikarago EI,Musabyimana JP,Habimana JP,Karema C,Krogstad DJ

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:It was unknown whether the main reservoir of Plasmodium falciparum and Plasmodium vivax, which infects mosquitoes in Thailand, was (a) in people feeling sufficiently ill with malaria to come to a clinic or (b) in people who had remained in their home villages with some fever symptoms or with none. METHODS:M...

journal_title：Malaria journal

authors： Pethleart A,Prajakwong S,Suwonkerd W,Corthong B,Webber R,Curtis C

更新日期：2004-09-22 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:Plasmodium knowlesi is the fifth Plasmodium species that can infect humans. The Plasmodium merozoite surface protein-1(42) (MSP-1(42)) is a potential candidate for malaria vaccine. However, limited studies have focused on P. knowlesi MSP-1(42). METHODS:A ~42 kDa recombinant P. knowlesi MSP-1(42) (pkMSP-1(42...

journal_title：Malaria journal

authors： Cheong FW,Fong MY,Lau YL,Mahmud R

更新日期：2013-12-19 00:00:00

abstract：BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...

journal_title：Malaria journal

authors： Kisinza WN,Nkya TE,Kabula B,Overgaard HJ,Massue DJ,Mageni Z,Greer G,Kaspar N,Mohamed M,Reithinger R,Moore S,Lorenz LM,Magesa S

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. METHODS:An increm...

journal_title：Malaria journal

authors： Moore BR,Davis WA,Clarke PM,Robinson LJ,Laman M,Davis TME

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:The epidemiological control of malaria has been hampered by the appearance of parasite resistance to anti-malarial drugs and by the resistance of mosquito vectors to control measures. This has also been associated with weak transmission control, mostly due to poor control of asymptomatic patients associated ...

journal_title：Malaria journal

authors： Ararat-Sarria M,Prado CC,Camargo M,Ospina LT,Camargo PA,Curtidor H,Patarroyo MA

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...

journal_title：Malaria journal

authors： van Schalkwyk DA,Burrow R,Henriques G,Gadalla NB,Beshir KB,Hasford C,Wright SG,Ding XC,Chiodini PL,Sutherland CJ

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors and malaria prevalence in Indonesia. METHODS:The study used a cross-sectional design and analysed re...

journal_title：Malaria journal

authors： Hasyim H,Dale P,Groneberg DA,Kuch U,Müller R

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Anopheles baimaii is a primary vector of human malaria in the forest settings of Southeast Asia including the north-eastern region of India. Here, the genetic population structure and the basic population genetic parameters of An. baimaii in north-east India were estimated using DNA sequences of the mitochon...

journal_title：Malaria journal

authors： Sarma DK,Prakash A,O'Loughlin SM,Bhattacharyya DR,Mohapatra PK,Bhattacharjee K,Das K,Singh S,Sarma NP,Ahmed GU,Walton C,Mahanta J

更新日期：2012-03-20 00:00:00

abstract：BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...

journal_title：Malaria journal

authors： González C,Molina AG,León C,Salcedo N,Rondón S,Paz A,Atencia MC,Tovar C,Ortiz M

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost, poor availability, and technical difficulty. With the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analys...

journal_title：Malaria journal

authors： Kafsack BF,Painter HJ,Llinás M

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...

journal_title：Malaria journal

authors： Ojakaa DI,Jarvis JD,Matilu MI,Thiam S

更新日期：2014-05-05 00:00:00