Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.

abstract：BACKGROUND:Malaria remains a major public health problem, and its control has been hampered by drug resistance. For a number of drugs, Plasmodium falciparum single nucleotide polymorphisms (SNPs) are associated with altered drug sensitivity and can be used as markers of drug resistance. Several techniques have been stu...

journal_title：Malaria journal

authors： Nankoberanyi S,Mbogo GW,LeClair NP,Conrad MD,Tumwebaze P,Tukwasibwe S,Kamya MR,Tappero J,Nsobya SL,Rosenthal PJ

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...

journal_title：Malaria journal

authors： Grossenbacher B,Holzschuh A,Hofmann NE,Omar KA,Stuck L,Fakih BS,Ali A,Yukich J,Hetzel MW,Felger I

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Complex malaria infections are defined as those containing more than one genetically distinct lineage of Plasmodium parasite. Complexity of infection (COI) is a useful parameter to estimate from patient blood samples because it is associated with clinical outcome, epidemiology and disease transmission rate. ...

journal_title：Malaria journal

authors： Galinsky K,Valim C,Salmier A,de Thoisy B,Musset L,Legrand E,Faust A,Baniecki ML,Ndiaye D,Daniels RF,Hartl DL,Sabeti PC,Wirth DF,Volkman SK,Neafsey DE

更新日期：2015-01-19 00:00:00

abstract：BACKGROUND:Many malaria-related studies depend on infected red blood cells (iRBCs) as fundamental material; however, infected blood samples from human or animal models include leukocytes (white blood cells or WBCs), especially difficult to separate from iRBCs in cases involving Plasmodium vivax. These host WBCs are a s...

journal_title：Malaria journal

authors： Tao ZY,Xia H,Cao J,Gao Q

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...

journal_title：Malaria journal

authors： Graz B,Dicko M,Willcox ML,Lambert B,Falquet J,Forster M,Giani S,Diakite C,Dembele EM,Diallo D,Barennes H

更新日期：2008-11-23 00:00:00

abstract：BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...

journal_title：Malaria journal

authors： Lievens M,Aponte JJ,Williamson J,Mmbando B,Mohamed A,Bejon P,Leach A

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Malaria is a major public health problem in endemic countries including Sudan, where about 75% of populations are at risk. Due to widespread of chloroquine-resistant strains of Plasmodium falciparum, artemisinin-based combination therapy (ACT) is currently treatment of choice for malaria in the vast majority...

journal_title：Malaria journal

authors： Adam I,Ibrahim Y,Gasim GI

更新日期：2018-03-13 00:00:00

abstract：:While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to be effective, limited disease transmission, achieved through rapid...

journal_title：Malaria journal

authors： Makanga M

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, an...

journal_title：Malaria journal

authors： Ringsted FM,Bygbjerg IC,Samuelsen H

更新日期：2006-11-20 00:00:00

abstract：BACKGROUND:As Swaziland progresses towards national malaria elimination, the importation of parasites into receptive areas becomes increasingly important. Imported infections have the potential to instigate local transmission and sustain local parasite reservoirs. METHODS:Travel histories from Swaziland's routine surv...

journal_title：Malaria journal

authors： Tejedor-Garavito N,Dlamini N,Pindolia D,Soble A,Ruktanonchai NW,Alegana V,Le Menach A,Ntshalintshali N,Dlamini B,Smith DL,Tatem AJ,Kunene S

更新日期：2017-09-08 00:00:00

abstract：BACKGROUND:Challenges persist in ensuring access to and optimal use of long-lasting, insecticidal bed nets (LLINs). Factors associated with ownership and use may differ depending on the history of malaria and prevention control efforts in a specific region. Understanding how the cultural and social-environmental contex...

journal_title：Malaria journal

authors： Ernst KC,Hayden MH,Olsen H,Cavanaugh JL,Ruberto I,Agawo M,Munga S

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) largely account for the scale-up of malaria diagnosis in endemic settings. However, diversity in labelling including the instructions for use (IFU) limits their interchangeability and user-friendliness. Uniform, easy to follow and consistent labelling, aligned with international...

journal_title：Malaria journal

authors： Jacobs J,Barbé B,Gillet P,Aidoo M,Serra-Casas E,Van Erps J,Daviaud J,Incardona S,Cunningham J,Visser T

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...

journal_title：Malaria journal

authors： Kibret S,Lautze J,McCartney M,Nhamo L,Wilson GG

更新日期：2016-09-05 00:00:00

abstract：:The National Vector Borne Disease Control Programme (NVBDCP) of the Ministry of Health, Government of India is reporting about 2 million parasite positive cases each year, although case incidence is 30-fold or more under-estimated. Forty five to fifty percent of Plasmodium infections are caused by Plasmodium falciparu...

journal_title：Malaria journal

authors： Sharma VP

更新日期：2007-08-07 00:00:00

abstract：BACKGROUND:For future eradication strategies of malaria it is important to control the transmission of gametocytes from humans to the anopheline vector which causes the spread of the disease. Sensitive, non-invasive methods to detect gametocytes under field conditions can play a role in monitoring transmission potentia...

journal_title：Malaria journal

authors： Kast K,Berens-Riha N,Zeynudin A,Abduselam N,Eshetu T,Löscher T,Wieser A,Shock J,Pritsch M

更新日期：2013-12-04 00:00:00

abstract：BACKGROUND:Malaria is a leading global cause of preventable morbidity and mortality, especially in sub-Saharan Africa, despite recent advances in treatment and prevention technologies. Scale-up and wide distribution of long-lasting insecticide-treated nets (LLINs) could rapidly decrease malarial disease in endemic area...

journal_title：Malaria journal

authors： Dye TD,Apondi R,Lugada ES,Kahn JG,Smith J,Othoro C

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Anti-malarial treatments effectiveness remains a critical challenge for control programmes. However, when drug efficacy is established, the dose is calculated based on a predefined weight according to the patient age. Based on the hypothesis that the standard assumption of weight according to the age when ad...

journal_title：Malaria journal

authors： Djimde M,Samouda H,Jacobs J,Niangaly H,Tekete M,Sombie SB,Mgina EJ,Fofana B,Sagara I,Doumbo OK,Vaillant M,Djimde AA

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Members of the Anopheles punctulatus group (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Understanding why only certain species are able to transmit malaria requires a better comprehension of ...

journal_title：Malaria journal

authors： Logue K,Chan ER,Phipps T,Small ST,Reimer L,Henry-Halldin C,Sattabongkot J,Siba PM,Zimmerman PA,Serre D

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-base...

journal_title：Malaria journal

authors： Mnyone LL,Lyimo IN,Lwetoijera DW,Mpingwa MW,Nchimbi N,Hancock PA,Russell TL,Kirby MJ,Takken W,Koenraadt CJ

更新日期：2012-03-26 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

journal_title：Malaria journal

authors： Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS:Samples were collected on filter paper f...

journal_title：Malaria journal

authors： Inoue J,Lopes D,do Rosário V,Machado M,Hristov AD,Lima GF,Costa-Nascimento MJ,Segurado AC,Di Santi SM

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes. Measuring the infectivity of low gametocyte densities has become increa...

journal_title：Malaria journal

authors： Reuling IJ,Stone WJR,van de Vegte-Bolmer M,van Gemert GJ,Siebelink-Stoter R,Graumans W,Lanke K,Bousema T,Sauerwein RW

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...

journal_title：Malaria journal

authors： Junior SG,Pamplona VM,Corvelo TC,Ramos EM

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...

journal_title：Malaria journal

authors： Buregyeya E,Rutebemberwa E,LaRussa P,Lal S,Clarke SE,Hansen KS,Magnussen P,Mbonye AK

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing dema...

journal_title：Malaria journal

authors： Mannan A,Ahmed I,Arshad W,Asim MF,Qureshi RA,Hussain I,Mirza B

更新日期：2010-11-04 00:00:00

abstract：BACKGROUND:Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities. METHODS:A comprehensive screening methods were designed to identify novel anti-ma...

journal_title：Malaria journal

authors： Teklemichael AA,Mizukami S,Toume K,Mosaddeque F,Kamel MG,Kaneko O,Komatsu K,Karbwang J,Huy NT,Hirayama K

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Appropriate case management of suspected malaria in Cambodia is critical given anti-malarial drug resistance in the region. Improving diagnosis and the use of recommended malarial treatments is a challenge in Cambodia where self-treatment and usage of drug cocktails is widespread, a notable difference from m...

journal_title：Malaria journal

authors： O'Connell KA,Samandari G,Phok S,Phou M,Dysoley L,Yeung S,Allen H,Littrell M

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:The number of clinical cases of malaria is often recorded in resource constrained or conflict settings as a proxy for disease burden. Interpreting case count data in areas of humanitarian need is challenging due to uncertainties in population size caused by security concerns, resource constraints and populat...

journal_title：Malaria journal

authors： Hellewell J,Walker P,Ghani A,Rao B,Churcher TS

更新日期：2018-08-29 00:00:00