Abstract:
BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the statistical analysis and the rationale for their selection. The methods used to estimate efficacy of the primary course of vaccination, and of a booster dose, in preventing clinical episodes of uncomplicated and severe malaria, and to determine the duration of protection, are described. The interpretation of various measures of efficacy in terms of the potential public health impact of the vaccine is discussed. CONCLUSIONS:The methodology selected to analyse the clinical trial must be scientifically sound, acceptable to regulatory authorities and meaningful to those responsible for malaria control and public health policy.
journal_name
Malar Jjournal_title
Malaria journalauthors
Lievens M,Aponte JJ,Williamson J,Mmbando B,Mohamed A,Bejon P,Leach Adoi
10.1186/1475-2875-10-222subject
Has Abstractpub_date
2011-08-04 00:00:00pages
222issn
1475-2875pii
1475-2875-10-222journal_volume
10pub_type
杂志文章,随机对照试验相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:The relationship between mosquito development and temperature is one of the keys to understanding the current and future dynamics and distribution of vector-borne diseases such as malaria. Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densitie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-196
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3057-7
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03253-1
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1781-4
更新日期:2017-03-27 00:00:00
abstract:BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-12
更新日期:2007-01-26 00:00:00
abstract:BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1586-x
更新日期:2016-11-09 00:00:00
abstract:BACKGROUND:In children with malaria caused by Plasmodium falciparum, quinine administered rectally may be easier to use and less painful than intramuscular or intravenous administration. The objective of this review was to compare the effectiveness of intrarectal with intravenous or intramuscular quinine for treating f...
journal_title:Malaria journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1475-2875-4-24
更新日期:2005-05-18 00:00:00
abstract:BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-279
更新日期:2012-08-17 00:00:00
abstract:BACKGROUND:The malaria rapid diagnostic tests (RDTs) are now widely used in the world. Compared to Plasmodium falciparum, a poor sensitivity of RDTs was reported against Plasmodium vivax based on the adopted antibody against pan-Plasmodium antigen lactate dehydrogenase (pLDH) or aldolase. Levels of pLDH were measured f...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-181
更新日期:2013-06-03 00:00:00
abstract:BACKGROUND:Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. However, people with glucose-6-phosphate dehydrogenase (G...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2715-0
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Kohat district is one of the medium intensity malaria transmission areas in Pakistan where asymptomatic carriers are likely to form a reservoir of infection. This study was done to explore the possibility of using microscopy, rapid diagnostic testing (RDT), real time polymerase chain reaction (RT-PCR) and RT...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2191-y
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission settings or in populations on the cusp of elimination. However, most of studies are designed to contro...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0661-z
更新日期:2015-04-03 00:00:00
abstract:BACKGROUND:The sulphadoxine/pyrimethamine (SDX/PYR) combination had been chosen to treat uncomplicated falciparum malaria in Malaysia for more than 30 years. Non-silent mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes are responsible for the resistance to pyrimethamine and sulphadox...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-445
更新日期:2013-12-10 00:00:00
abstract:BACKGROUND:Plasmodium falciparum malaria is a significant problem around the world today, thus there is still a need for new control methods to be developed. Because the sporozoite displays dual infectivity for both the mosquito salivary glands and vertebrate host tissue, it is a good target for vaccine development. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-80
更新日期:2012-03-23 00:00:00
abstract:BACKGROUND:Increasing access to health care services is considered central to improving the health of populations. Existing reviews to understand factors affecting access to health care have focused on attributes of patients and their communities that act as 'barriers' to access, such as education level, financial and ...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-11-55
更新日期:2012-02-23 00:00:00
abstract:BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-360
更新日期:2013-10-10 00:00:00
abstract:BACKGROUND:Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine. In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids. ME...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-261
更新日期:2010-09-18 00:00:00
abstract:BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1498-9
更新日期:2016-09-05 00:00:00
abstract:BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-251
更新日期:2009-11-05 00:00:00
abstract::BACKGROUND: In areas of high-level, year-round malaria transmission, morbidity and mortality due to malaria decrease after the first two to three years of life. This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falcipar...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-2-37
更新日期:2003-11-05 00:00:00
abstract:BACKGROUND:Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS:Samples were collected on filter paper f...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-372
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-248
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:Defining the number and location of sprayable structures (houses) is foundational to plan and monitor indoor residual spray (IRS) implementation, a primary intervention used to control the transmission of malaria. Only by mapping the location and type of all sprayable structures can IRS operations be planned...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0831-z
更新日期:2015-09-17 00:00:00
abstract:BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-172
更新日期:2014-05-05 00:00:00
abstract:BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1597-7
更新日期:2016-11-09 00:00:00
abstract:BACKGROUND:Molecular tools for detection of low-density asymptomatic Plasmodium infections are needed in malaria elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic malaria in Zanzibar. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0731-2
更新日期:2015-05-17 00:00:00
abstract:BACKGROUND:In areas with ongoing malaria transmission, strategies to clear parasites from populations can reduce infection and transmission. The objective of this paper was to describe a malaria mass testing and treatment (MTAT) intervention implemented in six kebeles (villages) in Amhara Region, Ethiopia, at the begin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1333-3
更新日期:2016-06-02 00:00:00
abstract:BACKGROUND:Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity. Because intravenous immunization has been considered to be unacceptable for large scale vaccination of ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-362
更新日期:2010-12-15 00:00:00
abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-12-399
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS:In this study the Binax NOW Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-10-300
更新日期:2011-10-14 00:00:00