Abstract:
BACKGROUND:In areas with ongoing malaria transmission, strategies to clear parasites from populations can reduce infection and transmission. The objective of this paper was to describe a malaria mass testing and treatment (MTAT) intervention implemented in six kebeles (villages) in Amhara Region, Ethiopia, at the beginning of the 2014 transmission season. METHODS:Intervention kebeles were selected based on incidence of passively detected Plasmodium falciparum and mixed (P. falciparum and P. vivax) malaria cases during the 2013 malaria transmission season. All households in intervention kebeles were targeted; consenting residents received a rapid diagnostic test (RDT) and RDT-positive individuals received artemether-lumefantrine for P. falciparum/mixed infections or chloroquine for P. vivax. Data were collected on MTAT participation, sociodemographic characteristics, malaria risk factors, and RDT positivity. RESULTS:Of 9162 households targeted, 7974 (87.0 %) participated in the MTAT. Among the 35,389 residents of these households, 30,712 (86.8 %) received an RDT. RDT-positivity was 1.4 % (0.3 % P. vivax, 0.7 % P. falciparum, 0.3 % mixed), ranging from 0.3 to 5.1 % by kebele; 39.4 % of RDT-positive individuals were febrile, 28.5 % resided in the same household with another RDT-positive individual, 23.0 % were not protected by vector control interventions [mosquito net or indoor residual spray (IRS)], and 7.1 % had travel history. For individuals under 10 years of age, the odds of being RDT-positive was significantly higher for those with fever, recent use of anti-malarial drugs or residing in the same household with another RDT-positive individual; 59.0 % of RDT-positive individuals had at least one of these risk factors. For individuals 10 years of age and older, the odds of being RDT positive was significantly higher for those with reported travel, fever, recent use of anti-malarial drugs, no use of vector control, and those residing in the same household as another RDT-positive individual; 71.2 % of RDT-positive individuals had at least one of these risk factors. CONCLUSIONS:In the Ethiopia setting, an MTAT intervention is operationally feasible and can be conducted with high coverage. RDT-positivity is low and varies widely by kebele. While several risk factors are significantly associated with RDT-positivity, there are still many RDT-positive individuals who do not have any of these risk factors. Strategies that target populations for testing and treatment based on these risk factors alone are likely to leave many infections undetected.
journal_name
Malar Jjournal_title
Malaria journalauthors
Scott CA,Yeshiwondim AK,Serda B,Guinovart C,Tesfay BH,Agmas A,Zeleke MT,Guesses GS,Ayenew AL,Workie WM,Steketee RW,Earle D,Bezabih B,Getachew Adoi
10.1186/s12936-016-1333-3subject
Has Abstractpub_date
2016-06-02 00:00:00pages
305issn
1475-2875pii
10.1186/s12936-016-1333-3journal_volume
15pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-133
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-394
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:A deeper understanding of the ecology and small-scale heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated in five villages in close proximity to a hydro-agri...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0871-4
更新日期:2015-09-05 00:00:00
abstract:BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-212
更新日期:2011-07-29 00:00:00
abstract:BACKGROUND:Universal coverage with long-lasting insecticidal mosquito nets (LLIN) or indoor residual spraying (IRS) of houses remain the primary strategies for the control of mosquito vectors of malaria. Pyrethroid resistant malaria vectors are widespread throughout sub-Saharan Africa and new insecticides with differen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0890-1
更新日期:2015-09-17 00:00:00
abstract:BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-129
更新日期:2007-09-24 00:00:00
abstract:BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-86
更新日期:2014-03-10 00:00:00
abstract:BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1498-9
更新日期:2016-09-05 00:00:00
abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-288
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts. METHODS:Sera from asymptomatic and symptomatic Plasmodium-infect...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-5
更新日期:2005-01-20 00:00:00
abstract:BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2186-8
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito. METHODS:381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-233
更新日期:2011-08-11 00:00:00
abstract::The substantial impact of cross-border collaborative control efforts on the burden of malaria in southern Africa has previously been demonstrated through the successes of the Lubombo Spatial Development Initiative. Increases in malaria cases recorded in the three partner countries (Mozambique, South Africa, Swaziland)...
journal_title:Malaria journal
pub_type: 社论
doi:10.1186/s12936-016-1470-8
更新日期:2016-08-18 00:00:00
abstract::Spain declared the elimination of malaria in 1964. In non-endemic areas, the overwhelming majority of malaria cases are acquired abroad, and locally acquired infections are rare events. In Spain, malaria is a statutorily notifiable disease. During these fifty years more than ten thousand malaria cases have been report...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-017-1915-8
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R and G353V) were rece...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03281-x
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Adequate malaria diagnosis and treatment remain major difficulties in rural sub-Saharan Africa. These issues deserve renewed attention in the light of first-line treatment with expensive artemisinin-combination therapy (ACT) and changing patterns of transmission intensity. This study describes diagnostic and...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-232
更新日期:2008-11-05 00:00:00
abstract:BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0546-1
更新日期:2015-02-05 00:00:00
abstract:BACKGROUND:The number of clinical cases of malaria is often recorded in resource constrained or conflict settings as a proxy for disease burden. Interpreting case count data in areas of humanitarian need is challenging due to uncertainties in population size caused by security concerns, resource constraints and populat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2460-9
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the con...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2307-4
更新日期:2018-04-11 00:00:00
abstract:BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-8-196
更新日期:2009-08-12 00:00:00
abstract:BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2875-6-65
更新日期:2007-05-22 00:00:00
abstract:BACKGROUND:Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is undermining the sustainability of these control strategies. Alternatives to the currently available co...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-71
更新日期:2010-03-08 00:00:00
abstract:BACKGROUND:The standard in vitro protocol currently in use for drug testing against Plasmodium falciparum, based on the incorporation of the purine [3H]-hypoxanthine, has two serious drawbacks. Firstly it is unsuitable for the testing of drugs that directly or indirectly impact on purine salvage or metabolism. Secondly...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-95
更新日期:2006-10-31 00:00:00
abstract:BACKGROUND:Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eli...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-57
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection and quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-bas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-55
更新日期:2014-02-14 00:00:00
abstract:BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-10-222
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Effective surveillance systems are required to track malaria testing and treatment practices. A 26-week study "SMS for Life" was piloted in five rural districts of Kenya to examine whether SMS reported surveillance data could ensure real-time visibility of accurate data and their use by district managers to ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-107
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2745-7
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Certain species of macaques are natural hosts of Plasmodium knowlesi and Plasmodium cynomolgi, which can both cause malaria in humans, and Plasmodium inui, which can be experimentally transmitted to humans. A significant number of zoonotic malaria cases have been reported in humans throughout Southeast Asia,...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03424-0
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1188-7
更新日期:2016-03-05 00:00:00