Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation.

abstract：:Recent WHO guidelines recommend a universal "test and treat" strategy for malaria, mainly by use of rapid diagnostic test (RDT) in all areas. The evidence for this approach is questioned here as there is a risk of over-reliance on parasitological diagnosis in high transmission situations, which still exist. In such ar...

journal_title：Malaria journal

authors： Graz B,Willcox M,Szeless T,Rougemont A

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falciparum infection consisting of chloroquine/sulphadoxine-pyrimethamine combination therapy. Chloro...

journal_title：Malaria journal

authors： Kinzer MH,Chand K,Basri H,Lederman ER,Susanti AI,Elyazar I,Taleo G,Rogers WO,Bangs MJ,Maguire JD

更新日期：2010-04-06 00:00:00

abstract：:Plasmodium knowlesi is a potentially life-threatening zoonotic malaria parasite due to its relatively short erythrocytic cycle. Microscopic identification of P. knowlesi is difficult, with "compacted parasite cytoplasm" being one of the important identifying keys. This report is about a case of hyperparasitaemic human...

journal_title：Malaria journal

authors： Lee WC,Chin PW,Lau YL,Chin LC,Fong MY,Yap CJ,Supramaniam RR,Mahmud R

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:Complex malaria infections are defined as those containing more than one genetically distinct lineage of Plasmodium parasite. Complexity of infection (COI) is a useful parameter to estimate from patient blood samples because it is associated with clinical outcome, epidemiology and disease transmission rate. ...

journal_title：Malaria journal

authors： Galinsky K,Valim C,Salmier A,de Thoisy B,Musset L,Legrand E,Faust A,Baniecki ML,Ndiaye D,Daniels RF,Hartl DL,Sabeti PC,Wirth DF,Volkman SK,Neafsey DE

更新日期：2015-01-19 00:00:00

abstract：BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...

journal_title：Malaria journal

authors： Zhu L,Marshall JM,Qualls WA,Schlein Y,McManus JW,Arheart KL,Hlaing WM,Traore SF,Doumbia S,Müller GC,Beier JC

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:The diversity of genotyping markers of Plasmodium falciparum depends on transmission intensity. It has been reported that the diversity of the merozoite surface protein 2 (msp2) is greater in areas of high compared to low endemicity, however, results for msp1 were inconsistent. These previous reports relied ...

journal_title：Malaria journal

authors： Schoepflin S,Valsangiacomo F,Lin E,Kiniboro B,Mueller I,Felger I

更新日期：2009-10-30 00:00:00

abstract：BACKGROUND:Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity. Because intravenous immunization has been considered to be unacceptable for large scale vaccination of ...

journal_title：Malaria journal

authors： Voza T,Kebaier C,Vanderberg JP

更新日期：2010-12-15 00:00:00

abstract：BACKGROUND:Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is ...

journal_title：Malaria journal

authors： Wilmot D,Ameyaw EO,Amoako-Sakyi D,Boampong JN,Quashie NB

更新日期：2017-03-04 00:00:00

abstract：BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...

journal_title：Malaria journal

authors： Pfeil J,Heine JF,Mueller AK

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS:In this study the Binax NOW Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and ...

journal_title：Malaria journal

authors： van Gool T,van Wolfswinkel ME,Koelewijn R,van Thiel PP,Jacobs J,van Hellemond JJ,van Genderen PJ

更新日期：2011-10-14 00:00:00

abstract：:The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

journal_title：Malaria journal

authors： Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

更新日期：2010-10-18 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Early diagnosis and prompt treatment including appropriate home-based treatment of malaria is a major strategy for malaria control. A major determinant of clinical outcome in case management is compliance and adherence to effective antimalarial regimen. Home-based malaria treatment with inappropriate medicin...

journal_title：Malaria journal

authors： Orimadegun AE,Amodu OK,Olumese PE,Omotade OO

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including game...

journal_title：Malaria journal

authors： Bosson-Vanga H,Franetich JF,Soulard V,Sossau D,Tefit M,Kane B,Vaillant JC,Borrmann S,Müller O,Dereuddre-Bosquet N,Le Grand R,Silvie O,Mazier D

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increas...

journal_title：Malaria journal

authors： Bruce MC,Macheso A,McConnachie A,Molyneux ME

更新日期：2011-02-11 00:00:00

abstract：BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

journal_title：Malaria journal

authors： Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of the human populations it affects. Low population densities in rural areas and high population densit...

journal_title：Malaria journal

authors： Tatem AJ,Guerra CA,Kabaria CW,Noor AM,Hay SI

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes reflect intraerythrocytic removal of malarial parasites with a concurrent removal of RBC membrane through...

journal_title：Malaria journal

authors： Anyona SB,Schrier SL,Gichuki CW,Waitumbi JN

更新日期：2006-07-31 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...

journal_title：Malaria journal

authors： Beer N,Ali AS,de Savigny D,Al-Mafazy AW,Ramsan M,Abass AK,Omari RS,Björkman A,Källander K

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Zooprophylaxis, the diversion of disease carrying insects from humans to animals, may reduce transmission of diseases such as malaria. However, as the number of animals increases, improved availability of blood meals may increase mosquito survival, thereby countering the impact of diverting feeds. METHODS:C...

journal_title：Malaria journal

authors： Saul A

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:Information is needed on the expected durability of insecticidal nets under operational conditions. The persistence of insecticidal efficacy is important to estimate the median serviceable life of nets under field conditions and to plan for net replacement. METHODS:Deltamethrin residue levels were evaluated...

journal_title：Malaria journal

authors： Anshebo GY,Graves PM,Smith SC,Wills AB,Damte M,Endeshaw T,Shargie EB,Gebre T,Mosher AW,Patterson AE,Emerson PM

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:The counterfeiting of anti-malarials represents a form of attack on global public health in which fake and substandard anti-malarials serve as de facto weapons of mass destruction, particularly in resource-constrained endemic settings, where malaria causes nearly 660,000 preventable deaths and threatens mill...

journal_title：Malaria journal

authors： Karunamoorthi K

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...

journal_title：Malaria journal

authors： Bharti PK,Silawat N,Singh PP,Singh MP,Shukla M,Chand G,Dash AP,Singh N

更新日期：2008-07-11 00:00:00

abstract：:Unfortunately after publication of the original article [1], it came to the author's attention that there is an error in the caption of Fig. 2. ...

journal_title：Malaria journal

authors： Mwandagalirwa MK,Levitz L,Thwai KL,Parr JB,Goel V,Janko M,Tshefu A,Emch M,Meshnick SR,Carrel M

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify urinary biomarkers of falciparum malaria. METHODS:The study used a ca...

journal_title：Malaria journal

authors： Abdelrazig S,Ortori CA,Davey G,Deressa W,Mulleta D,Barrett DA,Amberbir A,Fogarty AW

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Following the recognition that morbidity and mortality due to malaria had dramatically increased in the last three decades, in 2002 the government of Zambia reviewed its efforts to prevent and treat malaria. Convincing evidence of the failing efficacy of chloroquine resulted in the initiation of a process th...

journal_title：Malaria journal

authors： Sipilanyambe N,Simon JL,Chanda P,Olumese P,Snow RW,Hamer DH

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...

journal_title：Malaria journal

authors： Taylor DW,Bobbili N,Khadka VS,Quakyi IA,Leke RG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Intermittent preventive (or presumptive) treatment of infants (IPTi), the administration of a curative anti-malarial dose to infants whether or not they are known to be infected, is being considered as a new strategy for malaria control. Five of the six trials using sulphadoxine-pyrimethamine (SP) for IPTi s...

journal_title：Malaria journal

authors： Gosling RD,Ghani AC,Deen JL,von Seidlein L,Greenwood BM,Chandramohan D

更新日期：2008-04-03 00:00:00

abstract：BACKGROUND:Knowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the geneti...

journal_title：Malaria journal

authors： Maneerattanasak S,Gosi P,Krudsood S,Tongshoob J,Lanteri CA,Snounou G,Khusmith S

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in vitro. However, they are inflammatory and alter the permeability of the blood-brain barrier, rai...

journal_title：Malaria journal

authors： Recuenco FC,Takano R,Chiba S,Sugi T,Takemae H,Murakoshi F,Ishiwa A,Inomata A,Horimoto T,Kobayashi Y,Horiuchi N,Kato K

更新日期：2014-12-11 00:00:00