Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity.

abstract：BACKGROUND:Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not ava...

journal_title：Malaria journal

authors： Vachot-Ganée L,Khim N,Iannello A,Legrand E,Kim S,Eam R,Khean C,Ken M,Ashley E,Tun KM,Dhorda M,Nosten F,Souleymane IM,Blein S,Pachot A,Ariey F,Kaiser K,Ménard D

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Prompt and correct diagnosis of malaria is crucial for accurate epidemiological assessment and better case management, and while the gold standard of light microscopy is often available, it requires both expertise and time. Portable fluorescent microscopy using the CyScope offers a potentially quicker, easie...

journal_title：Malaria journal

authors： Sousa-Figueiredo JC,Oguttu D,Adriko M,Besigye F,Nankasi A,Arinaitwe M,Namukuta A,Betson M,Kabatereine NB,Stothard JR

更新日期：2010-08-27 00:00:00

abstract：BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...

journal_title：Malaria journal

authors： Stica C,Jeffries CL,Irish SR,Barry Y,Camara D,Yansane I,Kristan M,Walker T,Messenger LA

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...

journal_title：Malaria journal

authors： Weidner T,Lucantoni L,Nasereddin A,Preu L,Jones PG,Dzikowski R,Avery VM,Kunick C

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. METHODS:Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quan...

journal_title：Malaria journal

authors： Kakande E,Greenhouse B,Bajunirwe F,Drakeley C,Nankabirwa JI,Walakira A,Nsobya SL,Katureebe A,Rek J,Arinaitwe E,Rosenthal PJ,Kamya MR,Dorsey G,Rodriguez-Barraquer I

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections. However methodological difficulties have impeded the use of nuclear markers such as m...

journal_title：Malaria journal

authors： Hellgren O,Kutzer M,Bensch S,Valkiūnas G,Palinauskas V

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the na...

journal_title：Malaria journal

authors： Mahaman Moustapha L,Adamou R,Ibrahim ML,Abdoulaye Louis Padounou M,Diallo A,Courtin D,Testa J,Ndiaye JLA

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

journal_title：Malaria journal

authors： Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...

journal_title：Malaria journal

authors： Setyadi A,Arguni E,Kenangalem E,Hasanuddin A,Lampah DA,Thriemer K,Anstey NM,Sugiarto P,Simpson JA,Price RN,Douglas NM,Poespoprodjo JR

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:There is an urgent need for an effective vaccine to control and eradicate malaria, one of the most serious global infectious diseases. Plasmodium merozoite surface protein 4 (MSP4) has been listed as a blood-stage subunit vaccine candidate for malaria. Infection with Plasmodium ovale species including P. ova...

journal_title：Malaria journal

authors： Uwase J,Chu R,Kassegne K,Lei Y,Shen F,Fu H,Sun Y,Xuan Y,Cao J,Cheng Y

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs...

journal_title：Malaria journal

authors： Duah NO,Matrevi SA,de Souza DK,Binnah DD,Tamakloe MM,Opoku VS,Onwona CO,Narh CA,Quashie NB,Abuaku B,Duplessis C,Kronmann KC,Koram KA

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8+ T cells targeting liver stage antigens can mediate sterile protection. T...

journal_title：Malaria journal

authors： Schwenk R,Banania G,Epstein J,Kim Y,Peters B,Belmonte M,Ganeshan H,Huang J,Reyes S,Stryhn A,Ockenhouse CF,Buus S,Richie TL,Sedegah M

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...

journal_title：Malaria journal

authors： Chanthap L,Ariey F,Socheat D,Tsuyuoka R,Bell D

更新日期：2010-01-23 00:00:00

abstract：BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...

journal_title：Malaria journal

authors： Ng'habi KR,Mwasheshi D,Knols BG,Ferguson HM

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

journal_title：Malaria journal

authors： Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for trea...

journal_title：Malaria journal

authors： Sutherland CJ,Laundy M,Price N,Burke M,Fivelman QL,Pasvol G,Klein JL,Chiodini PL

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:A previous study reported that the malaria parasite Plasmodium falciparum enters an altered growth state upon extracellular withdrawal of the essential amino acid isoleucine. Parasites slowed transit through the cell cycle when deprived of isoleucine prior to the onset of S-phase. METHODS:This project was u...

journal_title：Malaria journal

authors： McLean KJ,Jacobs-Lorena M

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:Behaviour change communication (BCC) can improve malaria prevention and treatment behaviour. As a one of the activities under Myanmar Artemisinin Resistance Containment (MARC) programme, BCC have been conducting. This study aimed to evaluate the effectiveness of the behaviour change communication and communi...

journal_title：Malaria journal

authors： Nyunt MH,Aye KM,Kyaw MP,Wai KT,Oo T,Than A,Oo HW,Phway HP,Han SS,Htun T,San KK

更新日期：2015-12-23 00:00:00

abstract：:The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as continuous surfaces using model-based geostatistical methods. The opportunities and limitations of these mapped o...

journal_title：Malaria journal

authors： Howes RE,Hawa K,Andriamamonjy VF,Franchard T,Miarimbola R,Mioramalala SA,Rafamatanantsoa JF,Rahantamalala MAM,Rajaobary SH,Rajaonera HDG,Rakotonindrainy AP,Rakotoson Andrianjatonavalona C,Randriamiarinjatovo DNAL,Randrianasolo

更新日期：2019-03-22 00:00:00

abstract：BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...

journal_title：Malaria journal

authors： González C,Molina AG,León C,Salcedo N,Rondón S,Paz A,Atencia MC,Tovar C,Ortiz M

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...

journal_title：Malaria journal

authors： Tougan T,Toya Y,Uchihashi K,Horii T

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost, poor availability, and technical difficulty. With the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analys...

journal_title：Malaria journal

authors： Kafsack BF,Painter HJ,Llinás M

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor transmission of malaria, particularly am...

journal_title：Malaria journal

authors： Crawshaw AF,Maung TM,Shafique M,Sint N,Nicholas S,Li MS,Roca-Feltrer A,Hii J

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...

journal_title：Malaria journal

authors： Hombhanje FW,Linge D,Saweri A,Kuanch C,Jones R,Toraso S,Geita J,Masta A,Kevau I,Hiawalyer G,Sapuri M

更新日期：2009-08-12 00:00:00

abstract：BACKGROUND:Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For a...

journal_title：Malaria journal

authors： de Gier B,Suryapranata FS,Croughs M,van Genderen PJ,Keuter M,Visser LG,van Vugt M,Sonder GJ

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Avian malaria vector competence studies are needed to understand more succinctly complex avian parasite-vector-relations. The lack of vector competence trials may be attributed to the difficulty of obtaining gametocytes for the majority of Plasmodium species and lineages. To conduct avian malaria infectivity...

journal_title：Malaria journal

authors： Carlson JS,Giannitti F,Valkiūnas G,Tell LA,Snipes J,Wright S,Cornel AJ

更新日期：2016-03-11 00:00:00