Immunogenicity analysis of conserved fragments in Plasmodium ovale species merozoite surface protein 4.

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00

abstract：:The Rethinking Malaria Leadership Forum, held at Harvard Business School in February 2017 with collaboration of the Barcelona Institute for Global Health and the Swiss Tropical and Public Health Institute, identified this training gap as a high priority for both analysis and action. The gap in human resource training ...

journal_title：Malaria journal

authors： Wirth DF,Casamitjana N,Tanner M,Reich MR

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:This study aimed to identify factors at individual and community level influencing insecticide-treated net (ITN) usage among groups of women of childbearing age (WOCBA) in Malawi. METHODS:Factors influencing ITN usage in Malawi were assessed through interviews with 16,130 WOCBA (15-49 years) across 850 comm...

journal_title：Malaria journal

authors： Nkoka O,Chuang TW,Chuang KY,Chen YH

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

journal_title：Malaria journal

authors： Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

更新日期：2013-12-20 00:00:00

abstract：BACKGROUND:Malaria transmission is complex and is believed to be associated with local climate changes. However, simple attempts to extrapolate malaria incidence rates from averaged regional meteorological conditions have proven unsuccessful. Therefore, the objective of this study was to determine if variations in spec...

journal_title：Malaria journal

authors： Loha E,Lindtjørn B

更新日期：2010-06-16 00:00:00

abstract：BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...

journal_title：Malaria journal

authors： Animut A,Negash Y,Kebede N

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...

journal_title：Malaria journal

authors： Kusi KA,Bosomprah S,Dodoo D,Kyei-Baafour E,Dickson EK,Mensah D,Angov E,Dutta S,Sedegah M,Koram KA

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS:A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and i...

journal_title：Malaria journal

authors： Lobo L,Cabral LIL,Sena MI,Guerreiro B,Rodrigues AS,de Andrade-Neto VF,Cristiano MLS,Nogueira F

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...

journal_title：Malaria journal

authors： Zou X,House BL,Zyzak MD,Richie TL,Gerbasi VR

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDT) and real-time PCR (qPCR) assays are sensitive for diagnosing malaria, but because they detect antigen and DNA, respectively, positivity may not reflect active infection. Performance characteristics of RDT and qPCR in Plasmodium falciparum positive specimens were evaluated over ti...

journal_title：Malaria journal

authors： Phuong M,Lau R,Ralevski F,Boggild AK

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region. Ghana adopted the WH...

journal_title：Malaria journal

authors： Nonvignon J,Aryeetey GC,Issah S,Ansah P,Malm KL,Ofosu W,Tagoe T,Agyemang SA,Aikins M

更新日期：2016-07-16 00:00:00

abstract：BACKGROUND:Relatively little is known about the prevalence of blood parasites in shorebirds, especially those breeding in the tropics. The prevalence of blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon was assessed in blood samples from Kentish plovers and cream-coloured coursers in Cape Verde, ...

journal_title：Malaria journal

authors： Martínez-de la Puente J,Eberhart-Phillips LJ,Cristina Carmona-Isunza M,Zefania S,Navarro MJ,Kruger O,Hoffman JI,Székely T,Figuerola J

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets (ITNs) conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the...

journal_title：Malaria journal

authors： Sedlmayr R,Fink G,Miller JM,Earle D,Steketee RW

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...

journal_title：Malaria journal

authors： Beer N,Ali AS,de Savigny D,Al-Mafazy AW,Ramsan M,Abass AK,Omari RS,Björkman A,Källander K

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resistance. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory prop...

journal_title：Malaria journal

authors： Mavondo GA,Mkhwananzi BN,Mabandla MV

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:Anopheles arabiensis is stereotypical of diverse vectors that mediate residual malaria transmission globally, because it can feed outdoors upon humans or cattle, or enter but then rapidly exit houses without fatal exposure to insecticidal nets or sprays. METHODS:Life histories of a well-characterized An. ar...

journal_title：Malaria journal

authors： Killeen GF,Govella NJ,Lwetoijera DW,Okumu FO

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito. METHODS:381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened...

journal_title：Malaria journal

authors： Maharaj R,Maharaj V,Crouch NR,Bhagwandin N,Folb PI,Pillay P,Gayaram R

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...

journal_title：Malaria journal

authors： Dev V,Sangma BM,Dash AP

更新日期：2010-09-22 00:00:00

abstract：BACKGROUND:Premature death of Plasmodium-infected erythrocytes is considered to favourably influence the clinical course of malaria. Aurothiomalate has previously been shown to trigger erythrocyte death or eryptosis, which is characterized by cell membrane scrambling leading to phosphatidylserine exposure at the cell s...

journal_title：Malaria journal

authors： Alesutan I,Bobbala D,Qadri SM,Estremera A,Föller M,Lang F

更新日期：2010-05-07 00:00:00

abstract：BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...

journal_title：Malaria journal

authors： Verma G,Surolia N

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...

journal_title：Malaria journal

authors： Mwangangi JM,Shililu J,Muturi EJ,Muriu S,Jacob B,Kabiru EW,Mbogo CM,Githure J,Novak RJ

更新日期：2010-08-09 00:00:00

abstract：BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...

journal_title：Malaria journal

authors： Kudella PW,Moll K,Wahlgren M,Wixforth A,Westerhausen C

更新日期：2016-04-18 00:00:00

abstract：:Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in endemic areas. Yet there is no currently integrated strategic approach on how this should be achieved. Malari...

journal_title：Malaria journal

authors： Brabin BJ,Warsame M,Uddenfeldt-Wort U,Dellicour S,Hill J,Gies S

更新日期：2008-12-11 00:00:00

abstract：BACKGROUND:The zoonotic malaria parasite Plasmodium knowlesi has become an emerging threat to South East Asian countries particular in Malaysia. A recent study from Sarawak (Malaysian Borneo) discovered two distinct normocyte binding protein xa (Pknbpxa) types of P. knowlesi. In the present study, the Pknbpxa of clinic...

journal_title：Malaria journal

authors： Ahmed MA,Fong MY,Lau YL,Yusof R

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Mal...

journal_title：Malaria journal

authors： Lima RB,Rocha e Silva LF,Melo MR,Costa JS,Picanço NS,Lima ES,Vasconcellos MC,Boleti AP,Santos JM,Amorim RC,Chaves FC,Coutinho JP,Tadei WP,Krettli AU,Pohlit AM

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of...

journal_title：Malaria journal

authors： Ntamabyaliro NY,Burri C,Nzolo DB,Engo AB,Lula YN,Mampunza SM,Nsibu CN,Mesia GK,Kayembe JN,Likwela JL,Kintaudi LM,Tona GL

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Rosette-formation of Plasmodium falciparum parasitized erythrocytes is of importance in the development of severe malaria. The parasite-derived molecule PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1), central to rosetting, is suggested to be included in a multimeric vaccine targeting severe di...

journal_title：Malaria journal

authors： Angeletti D,Albrecht L,Wahlgren M,Moll K

更新日期：2013-01-24 00:00:00

abstract：BACKGROUND:In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which consists of collecting information in real time and analysing this information for decision-making....

journal_title：Malaria journal

authors： Thomas A,Bakai TA,Atcha-Oubou T,Tchadjobo T,Voirin N

更新日期：2020-09-09 00:00:00