Survival analysis of diagnostic assays in Plasmodium falciparum malaria.

abstract：BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...

journal_title：Malaria journal

authors： Beer N,Ali AS,de Savigny D,Al-Mafazy AW,Ramsan M,Abass AK,Omari RS,Björkman A,Källander K

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:The Drugs for Neglected Diseases initiative (DNDi) is a not-for profit organization committed to providing affordable medicines and access to treatments in resource-poor settings. Traditionally drug development has happened "in house" within pharmaceutical companies, with research and development costs ultim...

journal_title：Malaria journal

authors： Wells S,Diap G,Kiechel JR

更新日期：2013-02-21 00:00:00

abstract：BACKGROUND:Knowledge of the ecological differences between the molecular forms of Anopheles gambiae and their sibling species, An. arabiensis might lead to understanding their unique contribution to disease transmission and to better vector control as well as to understanding the evolutionary forces that have separated...

journal_title：Malaria journal

authors： Yaro AS,Dao A,Adamou A,Crawford JE,Ribeiro JM,Gwadz R,Traoré SF,Lehmann T

更新日期：2006-03-22 00:00:00

abstract：BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...

journal_title：Malaria journal

authors： Smith PH,Mwangi JM,Afrane YA,Yan G,Obbard DJ,Ranford-Cartwright LC,Little TJ

更新日期：2011-06-08 00:00:00

abstract：BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...

journal_title：Malaria journal

authors： Weidner T,Lucantoni L,Nasereddin A,Preu L,Jones PG,Dzikowski R,Avery VM,Kunick C

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Policy makers, governments and donors are faced with an information gap when considering ways to improve access to artemisinin-based combination therapy (ACT) and malaria diagnostics including rapid diagnostic tests (RDTs). To help address some of these gaps, a five-year multi-country research project called...

journal_title：Malaria journal

authors： Shewchuk T,O'Connell KA,Goodman C,Hanson K,Chapman S,Chavasse D

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter plants. One possible approach to the identification of new antimalarial drug candidates is to searc...

journal_title：Malaria journal

authors： Randrianarivelojosia M,Rasidimanana VT,Rabarison H,Cheplogoi PK,Ratsimbason M,Mulholland DA,Mauclère P

更新日期：2003-07-24 00:00:00

abstract：BACKGROUND:Species of anopheline mosquitoes are largely distributed over emerged lands around the world and, within the tropics, few areas are without these insects, which are vectors of malaria parasites. Among the exceptions is the Seychelles archipelago in the western Indian Ocean. However, in the Aldabra island gro...

journal_title：Malaria journal

authors： Robert V,Rocamora G,Julienne S,Goodman SM

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities. METHODS:A comprehensive screening methods were designed to identify novel anti-ma...

journal_title：Malaria journal

authors： Teklemichael AA,Mizukami S,Toume K,Mosaddeque F,Kamel MG,Kaneko O,Komatsu K,Karbwang J,Huy NT,Hirayama K

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...

journal_title：Malaria journal

authors： Kibret S,Lautze J,McCartney M,Nhamo L,Wilson GG

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...

journal_title：Malaria journal

authors： Haque U,Magalhães RJ,Reid HL,Clements AC,Ahmed SM,Islam A,Yamamoto T,Haque R,Glass GE

更新日期：2010-05-09 00:00:00

abstract：BACKGROUND:Most of the current biophysical models designed to address the large-scale distribution of malaria assume that transmission of the disease is independent of the vector involved. Another common assumption in these type of model is that the mortality rate of mosquitoes is constant over their life span and that...

journal_title：Malaria journal

authors： Lunde TM,Korecha D,Loha E,Sorteberg A,Lindtjørn B

更新日期：2013-01-23 00:00:00

abstract：BACKGROUND:Genetically-modified (GM) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. Public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (GMOs) face strong scepticism in d...

journal_title：Malaria journal

authors： Marshall JM,Touré MB,Traore MM,Famenini S,Taylor CE

更新日期：2010-05-14 00:00:00

abstract：BACKGROUND:The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands. And, there is a push for intensified vector control in Guadalcanal, to improve the livelihood of residents and to minimize the number of cases, which are regularly exported to the rest of the country. The...

journal_title：Malaria journal

authors： Bugoro H,Hii JL,Butafa C,Iro'ofa C,Apairamo A,Cooper RD,Chen CC,Russell TL

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...

journal_title：Malaria journal

authors： DaRe JT,Mehlotra RK,Michon P,Mueller I,Reeder J,Sharma YD,Stoneking M,Zimmerman PA

更新日期：2007-03-21 00:00:00

abstract：BACKGROUND:Two major cities in West Africa, Accra, the capital of Ghana, and Lagos, the largest city of Nigeria, have significant problems with substandard pharmaceuticals. Both have actively combated the problem in recent years, particularly by screening products on the market using the Global Pharma Health Fund e.V. ...

journal_title：Malaria journal

authors： Bate R,Hess K

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum and an antigen common to the four species. Plasmodium vivax-specific RDTs target P. vivax-specific parasite lactate dehydrogenase (Pv-pLDH). Previous observations of false positive Pv-pLDH test lines in P. falciparum samples incited to t...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,van den Ende J,van Esbroeck M,Jacobs J

更新日期：2010-07-10 00:00:00

abstract：BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...

journal_title：Malaria journal

authors： Graz B,Dicko M,Willcox ML,Lambert B,Falquet J,Forster M,Giani S,Diakite C,Dembele EM,Diallo D,Barennes H

更新日期：2008-11-23 00:00:00

abstract：BACKGROUND:Prompt and correct diagnosis of malaria is crucial for accurate epidemiological assessment and better case management, and while the gold standard of light microscopy is often available, it requires both expertise and time. Portable fluorescent microscopy using the CyScope offers a potentially quicker, easie...

journal_title：Malaria journal

authors： Sousa-Figueiredo JC,Oguttu D,Adriko M,Besigye F,Nankasi A,Arinaitwe M,Namukuta A,Betson M,Kabatereine NB,Stothard JR

更新日期：2010-08-27 00:00:00

abstract：BACKGROUND:The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections. However methodological difficulties have impeded the use of nuclear markers such as m...

journal_title：Malaria journal

authors： Hellgren O,Kutzer M,Bensch S,Valkiūnas G,Palinauskas V

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Early diagnosis and prompt treatment including appropriate home-based treatment of malaria is a major strategy for malaria control. A major determinant of clinical outcome in case management is compliance and adherence to effective antimalarial regimen. Home-based malaria treatment with inappropriate medicin...

journal_title：Malaria journal

authors： Orimadegun AE,Amodu OK,Olumese PE,Omotade OO

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to...

journal_title：Malaria journal

authors： van Wolfswinkel ME,Koopmans LC,Hesselink DA,Hoorn EJ,Koelewijn R,van Hellemond JJ,van Genderen PJ

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

journal_title：Malaria journal

authors： Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:The malaria rapid diagnostic tests (RDTs) are now widely used in the world. Compared to Plasmodium falciparum, a poor sensitivity of RDTs was reported against Plasmodium vivax based on the adopted antibody against pan-Plasmodium antigen lactate dehydrogenase (pLDH) or aldolase. Levels of pLDH were measured f...

journal_title：Malaria journal

authors： Jang JW,Cho CH,Han ET,An SS,Lim CS

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measur...

journal_title：Malaria journal

authors： Dell'Acqua R,Fabrizio C,Di Gennaro F,Lo Caputo S,Saracino A,Menegon M,L'Episcopia M,Severini C,Monno L,Castelli F,Angarano G

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...

journal_title：Malaria journal

authors： Mora-Ruiz M,Penilla RP,Ordóñez JG,López AD,Solis F,Torres-Estrada JL,Rodríguez AD

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining interventions provides added benefit in reducing mortality and morbidity from malaria. The potential benefits of combining IPT in children (IPTc) with ho...

journal_title：Malaria journal

authors： Sesay S,Milligan P,Touray E,Sowe M,Webb EL,Greenwood BM,Bojang KA

更新日期：2011-01-07 00:00:00

abstract：BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...

journal_title：Malaria journal

authors： Chitsanoor S,Somsri S,Panburana P,Mungthin M,Ubalee R,Emyeam M,Jongwutiwes S,Sattabongkot J,Udomsangpetch R

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested...

journal_title：Malaria journal

authors： Gosi P,Khusmith S,Khalambaheti T,Lanar DE,Schaecher KE,Fukuda MM,Miller SR

更新日期：2008-06-26 00:00:00