Abstract:
BACKGROUND:The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands. And, there is a push for intensified vector control in Guadalcanal, to improve the livelihood of residents and to minimize the number of cases, which are regularly exported to the rest of the country. Therefore, the bionomics of the target vector, Anopheles farauti, was profiled in 2007-08; which was after 20 years of limited surveillance during which time treated bed nets (ITNs) were distributed in the area. METHODS:In three villages on northern Guadalcanal, blood-seeking female mosquitoes were caught using hourly human landing catches by four collectors, two working indoors and two outdoors, from 18.00-06.00 for at least two nights per month from July 2007 to June 2008. The mosquitoes were counted, identified using morphological and molecular markers and dissected to determine parity. RESULTS:Seasonality in vector densities was similar in the three villages, with a peak at the end of the drier months (October to December) and a trough at the end of the wetter months (March to May). There was some variability in endophagy (indoor biting) and nocturnal biting (activity during sleeping hours) both spatially and temporally across the longitudinal dataset. The general biting pattern was consistent throughout all sample collections, with the majority of biting occurring outdoors (64%) and outside of sleeping hours (65%). Peak biting was 19.00-20.00. The proportion parous across each village ranged between 0.54-0.58. Parity showed little seasonal trend despite fluctuations in vector densities over the year. CONCLUSION:The early, outdoor biting behaviour of An. farauti documented 20 years previously on north Guadalcanal was still exhibited. It is possible that bed net use may have maintained this biting profile though this could not be determined unequivocally. The longevity of these populations has not changed despite long-term ITN use. This early, outdoor biting behaviour led to the failure of the eradication programme and is likely responsible for the continued transmission in Guadalcanal following the introduction of ITNs. Other vector control strategies which do not rely on the vector entering houses are needed if elimination or intensified control is to be achieved.
journal_name
Malar Jjournal_title
Malaria journalauthors
Bugoro H,Hii JL,Butafa C,Iro'ofa C,Apairamo A,Cooper RD,Chen CC,Russell TLdoi
10.1186/1475-2875-13-56subject
Has Abstractpub_date
2014-02-15 00:00:00pages
56issn
1475-2875pii
1475-2875-13-56journal_volume
13pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Rapid diagnosis and correct treatment of cases are the main objectives of control programs in malaria-endemic areas. METHODS AND RESULTS:To evaluate these criteria and in a comparative study, blood specimens were collected from 120 volunteers seeking care at the Malaria Health Center in Chahbahar district. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-1-2
更新日期:2002-02-08 00:00:00
abstract:BACKGROUND:The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d'Ivoire, where palm oil plantations remain the predominant agricultural crop, the susceptibility of wild Anopheles...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1804-1
更新日期:2017-04-20 00:00:00
abstract:BACKGROUND:Due to the development of resistance to synthetic insecticides, adverse effects to human health, non-target organisms and the environment, there is an urgent need to develop new insecticides, which are effective, safe, biodegrable and target-specific. This study was undertaken to evaluate the adulticidal act...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-173
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-5
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-84
更新日期:2013-03-02 00:00:00
abstract:BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-7
更新日期:2011-01-12 00:00:00
abstract:BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-193
更新日期:2010-07-07 00:00:00
abstract:BACKGROUND:Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in a malaria-endemic region of Papua New Guinea (PNG). METHODS AND FINDINGS:Individuals with Plasmodi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-66
更新日期:2008-04-25 00:00:00
abstract:BACKGROUND:This paper reports on the availability of diagnostic tools and recommended anti-malarials in the 12-month period immediately following the implementation of a new national malaria treatment protocol (NMTP) in Papua New Guinea (PNG). Health worker adherence to the new NMTP is also examined and comparisons mad...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-433
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Unde...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03510-3
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:Determination of the genetic diversity of malaria parasites can inform the intensity of transmission and identify potential deficiencies in malaria control programmes. This study was conducted to characterize the genetic diversity and allele frequencies of Plasmodium falciparum in Northwest Ethiopia along th...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2540-x
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:Premature death of Plasmodium-infected erythrocytes is considered to favourably influence the clinical course of malaria. Aurothiomalate has previously been shown to trigger erythrocyte death or eryptosis, which is characterized by cell membrane scrambling leading to phosphatidylserine exposure at the cell s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-118
更新日期:2010-05-07 00:00:00
abstract:BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0546-1
更新日期:2015-02-05 00:00:00
abstract:BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-327
更新日期:2012-09-13 00:00:00
abstract:BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-180
更新日期:2009-07-31 00:00:00
abstract:BACKGROUND:Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China-Myanmar border to provide epidemio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2924-6
更新日期:2019-09-12 00:00:00
abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-12-399
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:Despite some problems related to accuracy and applicability, malaria rapid diagnostic tests (RDTs), are currently considered the best option in areas with limited laboratory services for improving case management and reducing over-treatment. However, their performance must be established taking into the acco...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-224
更新日期:2012-07-06 00:00:00
abstract:BACKGROUND:Most of the current biophysical models designed to address the large-scale distribution of malaria assume that transmission of the disease is independent of the vector involved. Another common assumption in these type of model is that the mortality rate of mosquitoes is constant over their life span and that...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-28
更新日期:2013-01-23 00:00:00
abstract:BACKGROUND:The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS:A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2281-x
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection and quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-bas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-55
更新日期:2014-02-14 00:00:00
abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-288
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDT) and real-time PCR (qPCR) assays are sensitive for diagnosing malaria, but because they detect antigen and DNA, respectively, positivity may not reflect active infection. Performance characteristics of RDT and qPCR in Plasmodium falciparum positive specimens were evaluated over ti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0882-1
更新日期:2015-09-17 00:00:00
abstract:BACKGROUND:Anopheles arabiensis is a dominant vector of malaria in sub-Saharan Africa, which feeds indoors and outdoors on human and other vertebrate hosts, making it a difficult species to control with existing control methods. Novel methods that reduce human-vector interactions are, therefore, required to improve the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1386-3
更新日期:2016-07-21 00:00:00
abstract:BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1839-3
更新日期:2017-05-15 00:00:00
abstract::The sterile insect technique (SIT) has been shown to be an effective and sustainable genetic approach to control populations of selected major pest insects, when part of area-wide integrated pest management (AW-IPM) programmes. The technique introduces genetic sterility in females of the target population in the field...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-8-S2-S1
更新日期:2009-11-16 00:00:00
abstract:BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03520-1
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Agro-ecological systems have been associated with increased malaria intensity. This study determined association between different agro-ecological systems, prevalence of malaria parasitaemia and anaemia in Mvomero district, Tanzania. METHODS:The study was carried out in three agro-ecosystems namely, savanna...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2859-y
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-190
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Adequate malaria diagnosis and treatment remain major difficulties in rural sub-Saharan Africa. These issues deserve renewed attention in the light of first-line treatment with expensive artemisinin-combination therapy (ACT) and changing patterns of transmission intensity. This study describes diagnostic and...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-232
更新日期:2008-11-05 00:00:00