Characterizing microclimate in urban malaria transmission settings: a case study from Chennai, India.

abstract：BACKGROUND:The WHO has reported that RDT and microscopy-confirmed malaria cases have declined in recent years. However, it is still unclear if this reflects a real decrease in incidence in Bangladesh, as particularly the hilly and forested areas of the Chittagong Hill Tract (CHT) Districts report more than 80% of all c...

journal_title：Malaria journal

authors： Starzengruber P,Fuehrer HP,Ley B,Thriemer K,Swoboda P,Habler VE,Jung M,Graninger W,Khan WA,Haque R,Noedl H

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) and mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria and the progression of MQ resistance. METHODS:The effectiveness of a fixed-dose combination of AS and MQ (ASM...

journal_title：Malaria journal

authors： Santelli AC,Ribeiro I,Daher A,Boulos M,Marchesini PB,dos Santos RL,Lucena MB,Magalhães I,Leon AP,Junger W,Ladislau JL

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS:A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and i...

journal_title：Malaria journal

authors： Lobo L,Cabral LIL,Sena MI,Guerreiro B,Rodrigues AS,de Andrade-Neto VF,Cristiano MLS,Nogueira F

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone derivatives, synthesized through one-post reactions from primaqui...

journal_title：Malaria journal

authors： Aguiar AC,Figueiredo FJ,Neuenfeldt PD,Katsuragawa TH,Drawanz BB,Cunico W,Sinnis P,Zavala F,Krettli AU

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...

journal_title：Malaria journal

authors： Smith TA

更新日期：2007-05-02 00:00:00

abstract：BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...

journal_title：Malaria journal

authors： Kojom LP,Singh V

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Malaria in Southeast Asia frequently clusters along international borders. For example, while most of Thailand is malaria free, the border region shared with Myanmar continues to have endemic malaria. This spatial pattern is the result of complex interactions between landscape, humans, mosquito vectors, and ...

journal_title：Malaria journal

authors： Parker DM,Carrara VI,Pukrittayakamee S,McGready R,Nosten FH

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:The Kilombero Valley is a highly malaria-endemic agricultural area in south-eastern Tanzania. Seasonal flooding of the valley is favourable to malaria transmission. During the farming season, many households move to distant field sites (shamba in Swahili) in the fertile river floodplain for the cultivation o...

journal_title：Malaria journal

authors： Hetzel MW,Alba S,Fankhauser M,Mayumana I,Lengeler C,Obrist B,Nathan R,Makemba AM,Mshana C,Schulze A,Mshinda H

更新日期：2008-01-09 00:00:00

abstract：BACKGROUND:Understanding of malaria vector density, distribution, insecticide resistance, vector incrimination, infection status, and identification of sibling species are some of the essential components of vector control measures for achieving malaria elimination goals. METHODS:As part of the malaria elimination dem...

journal_title：Malaria journal

authors： Mishra AK,Bharti PK,Vishwakarma A,Nisar S,Rajvanshi H,Sharma RK,Saha KB,Shukla MM,Jayswar H,Das A,Kaur H,Wattal SL,Lal AA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the public, providing many novel chemical starting points for anti-malarial drug disco...

journal_title：Malaria journal

authors： Le Manach C,Scheurer C,Sax S,Schleiferböck S,Cabrera DG,Younis Y,Paquet T,Street L,Smith P,Ding XC,Waterson D,Witty MJ,Leroy D,Chibale K,Wittlin S

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:Malaria control largely depends on availability of highly efficacious drugs, however, over the years, has been threatened by emergence of drug resistance. It is, therefore, important to monitor the impact of recurrent anti-malarial treatment on the long-term efficacy of anti-malarial regimens, especially in ...

journal_title：Malaria journal

authors： Byakika-Kibwika P,Nyakato P,Lamorde M,Kiragga AN

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:As in other countries of the Greater Mekong Sub-region (GMS), the private health sector constitutes a significant avenue where malaria services are provided and presents a unique opportunity for public-private collaboration. In September 2008, a public-private mix (PPM) strategy was launched initially in fou...

journal_title：Malaria journal

authors： Simmalavong N,Phommixay S,Kongmanivong P,Sichanthongthip O,Hongvangthong B,Gopinath D,Sintasath DM

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eli...

journal_title：Malaria journal

authors： Song J,Socheat D,Tan B,Dara P,Deng C,Sokunthea S,Seila S,Ou F,Jian H,Li G

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quality anti-malarials directly affect health outcomes by increasing malaria morbidity and mortality, as ...

journal_title：Malaria journal

authors： Ozawa S,Evans DR,Higgins CR,Laing SK,Awor P

更新日期：2019-01-09 00:00:00

abstract：BACKGROUND:In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which consists of collecting information in real time and analysing this information for decision-making....

journal_title：Malaria journal

authors： Thomas A,Bakai TA,Atcha-Oubou T,Tchadjobo T,Voirin N

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes. Measuring the infectivity of low gametocyte densities has become increa...

journal_title：Malaria journal

authors： Reuling IJ,Stone WJR,van de Vegte-Bolmer M,van Gemert GJ,Siebelink-Stoter R,Graumans W,Lanke K,Bousema T,Sauerwein RW

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and radio devices. Fluorescent dust is the most commonly used method to distinguish released individuals f...

journal_title：Malaria journal

authors： Aviles EI,Rotenberry RD,Collins CM,Dotson EM,Benedict MQ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is ...

journal_title：Malaria journal

authors： Wilmot D,Ameyaw EO,Amoako-Sakyi D,Boampong JN,Quashie NB

更新日期：2017-03-04 00:00:00

abstract：:The Global Technical Strategy 2016-2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria transmission, the reservoir of human infection may be intermittently symptomatic or fully silent yet still lea...

journal_title：Malaria journal

authors： Eisele TP

更新日期：2019-08-22 00:00:00

abstract：BACKGROUND:Invasion of host erythrocytes by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion involves recognition events between erythrocyte receptors and ligands on the merozoite, the invasive blood form of the parasite. Identifying and characterizing host-parasite interactions is impeded by t...

journal_title：Malaria journal

authors： Saetear P,Perrin AJ,Bartholdson SJ,Wanaguru M,Kussrow A,Bornhop DJ,Wright GJ

更新日期：2015-02-21 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for malaria provide a practical alternative to light microscopy for malaria diagnosis in resource-limited settings. Three-band RDTs incorporating two parasite antigens may have enhanced diagnostic specificity, relative to two-band RDTs with a single parasite antigen (typically h...

journal_title：Malaria journal

authors： Hawkes M,Conroy AL,Opoka RO,Namasopo S,Liles WC,John CC,Kain KC

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the efficacy of exchange transfusion in patients with severe imported falciparum malaria. Twelve patients who met the diagnostic criteria for severe malaria were treated with exchange transfusion 14 times according to a conventional anti-malarial treatment. This study eval...

journal_title：Malaria journal

authors： Lin J,Huang X,Qin G,Zhang S,Sun W,Wang Y,Ren K,Xu J,Han X

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...

journal_title：Malaria journal

authors： Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...

journal_title：Malaria journal

authors： Ng'habi KR,Mwasheshi D,Knols BG,Ferguson HM

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts. METHODS:Sera from asymptomatic and symptomatic Plasmodium-infect...

journal_title：Malaria journal

authors： Fesel C,Goulart LF,Silva Neto A,Coelho A,Fontes CJ,Braga EM,Vaz NM

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...

journal_title：Malaria journal

authors： Gomez-Elipe A,Otero A,van Herp M,Aguirre-Jaime A

更新日期：2007-09-24 00:00:00

abstract：BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...

journal_title：Malaria journal

authors： Haque U,Magalhães RJ,Reid HL,Clements AC,Ahmed SM,Islam A,Yamamoto T,Haque R,Glass GE

更新日期：2010-05-09 00:00:00

abstract：BACKGROUND:In the Tanga District of coastal Tanzania, malaria is one of the primary causes of mortality for children under the age of five. While some children are treated with malaria medications in biomedical facilities, as the World Health Organization recommends, others receive home-care or treatment from tradition...

journal_title：Malaria journal

authors： Foster D,Vilendrer S

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Malaria and schistosomiasis are endemic and co-exist in the same geographic areas, even co-infecting the same host. Previous studies have reported that concomitant infection with Schistosoma japonicum could offer protection against experimental cerebral malaria (ECM) in mice. This study was performed to eval...

journal_title：Malaria journal

authors： Wang ML,Feng YH,Pang W,Qi ZM,Zhang Y,Guo YJ,Luo EJ,Cao YM

更新日期：2014-03-26 00:00:00