In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products.

abstract：:This opinion article deals with the diagnostic clinical challenges faced by clinicians or health care workers in malaria-endemic areas when a severely sick child presents to the clinic with fever, coma or respiratory distress. Indeed, the coexistence of malaria with other severe infections like meningitis, invasive ba...

journal_title：Malaria journal

authors： Ackerman H,Casals-Pascual C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...

journal_title：Malaria journal

authors： Na-Bangchang K,Ruengweerayut R,Mahamad P,Ruengweerayut K,Chaijaroenkul W

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...

journal_title：Malaria journal

authors： Atemnkeng MA,De Cock K,Plaizier-Vercammen J

更新日期：2007-01-26 00:00:00

abstract：:Genetic manipulation of malaria parasites remains an inefficient, time-consuming and resource-intensive process. Presented here is a set of methods for 96-well plate-based transfection and culture that improve the efficiency of genetic manipulation of Plasmodium falciparum. Compared to standard protocols plate-based t...

journal_title：Malaria journal

authors： Caro F,Miller MG,DeRisi JL

更新日期：2012-01-18 00:00:00

abstract：BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...

journal_title：Malaria journal

authors： Laman M,Benjamin JM,Moore BR,Salib M,Tawat S,Davis WA,Siba PM,Robinson LJ,Davis TM

更新日期：2015-03-21 00:00:00

abstract：BACKGROUND:Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) and mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria and the progression of MQ resistance. METHODS:The effectiveness of a fixed-dose combination of AS and MQ (ASM...

journal_title：Malaria journal

authors： Santelli AC,Ribeiro I,Daher A,Boulos M,Marchesini PB,dos Santos RL,Lucena MB,Magalhães I,Leon AP,Junger W,Ladislau JL

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) to provide in-home diagnosis and treatment of these common childhood illnesses. For severely ill ch...

journal_title：Malaria journal

authors： English L,Miller JS,Mbusa R,Matte M,Kenney J,Bwambale S,Ntaro M,Patel P,Mulogo E,Stone GS

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...

journal_title：Malaria journal

authors： Ojakaa DI,Jarvis JD,Matilu MI,Thiam S

更新日期：2014-05-05 00:00:00

abstract：BACKGROUND:Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect malaria epidemiology. The different kinds of heterogeneity are likely to be correlated. Little is known about their impact on the shape...

journal_title：Malaria journal

authors： Ross A,Smith T

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for malaria provide a practical alternative to light microscopy for malaria diagnosis in resource-limited settings. Three-band RDTs incorporating two parasite antigens may have enhanced diagnostic specificity, relative to two-band RDTs with a single parasite antigen (typically h...

journal_title：Malaria journal

authors： Hawkes M,Conroy AL,Opoka RO,Namasopo S,Liles WC,John CC,Kain KC

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected people in the area and to identify the factors influencing malaria transmission. METHODS:Demograph...

journal_title：Malaria journal

authors： Sérandour J,Girel J,Boyer S,Ravanel P,Lemperière G,Raveton M

更新日期：2007-08-29 00:00:00

abstract：BACKGROUND:Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets (ITNs) conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the...

journal_title：Malaria journal

authors： Sedlmayr R,Fink G,Miller JM,Earle D,Steketee RW

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Mal...

journal_title：Malaria journal

authors： Lima RB,Rocha e Silva LF,Melo MR,Costa JS,Picanço NS,Lima ES,Vasconcellos MC,Boleti AP,Santos JM,Amorim RC,Chaves FC,Coutinho JP,Tadei WP,Krettli AU,Pohlit AM

更新日期：2015-12-18 00:00:00

abstract：:India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...

journal_title：Malaria journal

authors： Subbarao SK,Nanda N,Rahi M,Raghavendra K

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria whe...

journal_title：Malaria journal

authors： Njokah MJ,Kang'ethe JN,Kinyua J,Kariuki D,Kimani FT

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Patterns of decreasing malaria transmission intensity make presumptive treatment of malaria an unjustifiable approach in many African settings. The controlled use of anti-malarials after laboratory confirmed diagnosis is preferable in low endemic areas. Diagnosis may be facilitated by malaria rapid diagnosti...

journal_title：Malaria journal

authors： Bastiaens GJ,Schaftenaar E,Ndaro A,Keuter M,Bousema T,Shekalaghe SA

更新日期：2011-04-02 00:00:00

abstract：BACKGROUND:Plasmodium infections trigger complex immune reactions from their hosts against several life stages of the parasite, including gametocytes. These immune responses are highly variable, depending on age, genetics, and exposure history of the host as well as species and strain of parasite. Although the effects ...

journal_title：Malaria journal

authors： McQueen PG,Williamson KC,McKenzie FE

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:The standard in vitro protocol currently in use for drug testing against Plasmodium falciparum, based on the incorporation of the purine [3H]-hypoxanthine, has two serious drawbacks. Firstly it is unsuitable for the testing of drugs that directly or indirectly impact on purine salvage or metabolism. Secondly...

journal_title：Malaria journal

authors： Quashie NB,de Koning HP,Ranford-Cartwright LC

更新日期：2006-10-31 00:00:00

abstract：BACKGROUND:KwaZulu-Natal, one of South Africa's three malaria endemic provinces, is nearing malaria elimination, reporting fewer than 100 locally-acquired cases annually since 2010. Despite sustained implementation of essential interventions, including annual indoor residual spraying, prompt case detection using malari...

journal_title：Malaria journal

authors： Raman J,Gast L,Balawanth R,Tessema S,Brooke B,Maharaj R,Munhenga G,Tshikae P,Lakan V,Mwamba T,Makowa H,Sangweni L,Mkhabela M,Zondo N,Mohulatsi E,Nyawo Z,Ngxongo S,Msimang S,Dagata N,Greenhouse B,Birkholtz LM,Shi

更新日期：2020-04-15 00:00:00

abstract：:Following publication of the original article [1], one of the authors has highlighted an xml-related discrepancy concerning the author group titled 'Additional Tracking Resistance to Artemisinin Collaboration authors (TRAC Group Authorship)', listed under the Acknowledgements section. ...

journal_title：Malaria journal

authors： Srimuang K,Miotto O,Lim P,Fairhurst RM,Kwiatkowski DP,Woodrow CJ,Imwong M,Tracking Resistance to Artemisinin Collaboration.

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization. Safety, immunogenicity and efficacy of the RTS,S/AS02(D) vaccine candidate when integrated into a standard EPI schedul...

journal_title：Malaria journal

authors： Abdulla S,Salim N,Machera F,Kamata R,Juma O,Shomari M,Kubhoja S,Mohammed A,Mwangoka G,Aebi T,Mshinda H,Schellenberg D,Carter T,Villafana T,Dubois MC,Leach A,Lievens M,Vekemans J,Cohen J,Ballou WR,Tanner M

更新日期：2013-01-08 00:00:00

abstract：BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...

journal_title：Malaria journal

authors： Chitsanoor S,Somsri S,Panburana P,Mungthin M,Ubalee R,Emyeam M,Jongwutiwes S,Sattabongkot J,Udomsangpetch R

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:It was unknown whether the main reservoir of Plasmodium falciparum and Plasmodium vivax, which infects mosquitoes in Thailand, was (a) in people feeling sufficiently ill with malaria to come to a clinic or (b) in people who had remained in their home villages with some fever symptoms or with none. METHODS:M...

journal_title：Malaria journal

authors： Pethleart A,Prajakwong S,Suwonkerd W,Corthong B,Webber R,Curtis C

更新日期：2004-09-22 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Malaria is a major public health issue in Burundi in terms of both morbidity and mortality, with around 2.5 million clinical cases and more than 15,000 deaths each year. It is still the single main cause of mortality in pregnant women and children below five years of age. Because of the severe health and eco...

journal_title：Malaria journal

authors： Nkurunziza H,Gebhardt A,Pilz J

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in...

journal_title：Malaria journal

authors： Choowongkomon K,Theppabutr S,Songtawee N,Day NP,White NJ,Woodrow CJ,Imwong M

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...

journal_title：Malaria journal

authors： Thwing J,Ba F,Diaby A,Diedhiou Y,Sylla A,Sall G,Diouf MB,Gueye AB,Gaye S,Ndiop M,Cisse M,Ndiaye D,Ba M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:When discussing the relationship between meteorological factors and malaria, previous studies mainly focus on the interaction between different climatic factors, while the possible interaction within one particular climatic predictor at different lag periods has been largely neglected. In this study, this is...

journal_title：Malaria journal

authors： Wu Y,Qiao Z,Wang N,Yu H,Feng Z,Li X,Zhao X

更新日期：2017-01-31 00:00:00