New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum.

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Anopheles nuneztovari sensu lato comprises cryptic species in northern South America, and the Brazilian populations encompass distinct genetic lineages within the Brazilian Amazon region. This study investigated, based on two molecular markers, whether these lineages might actually deserve species status. M...

journal_title：Malaria journal

authors： Scarpassa VM,Cunha-Machado AS,Saraiva JF

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...

journal_title：Malaria journal

authors： DaRe JT,Mehlotra RK,Michon P,Mueller I,Reeder J,Sharma YD,Stoneking M,Zimmerman PA

更新日期：2007-03-21 00:00:00

abstract：:In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...

journal_title：Malaria journal

authors： Sampaio NG,Cheng L,Eriksson EM

更新日期：2017-06-09 00:00:00

abstract：BACKGROUND:Malaria is highly prevalent in many parts of India and is mostly caused by the parasite species Plasmodium vivax followed by Plasmodium falciparum. Chloroquine (CQ) is the first-line treatment for blood stage P. vivax parasites, but cases of drug resistance to CQ have been reported from India. One of the sur...

journal_title：Malaria journal

authors： Joy S,Mukhi B,Ghosh SK,Achur RN,Gowda DC,Surolia N

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...

journal_title：Malaria journal

authors： Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falciparum infection consisting of chloroquine/sulphadoxine-pyrimethamine combination therapy. Chloro...

journal_title：Malaria journal

authors： Kinzer MH,Chand K,Basri H,Lederman ER,Susanti AI,Elyazar I,Taleo G,Rogers WO,Bangs MJ,Maguire JD

更新日期：2010-04-06 00:00:00

abstract：BACKGROUND:The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d'Ivoire, where palm oil plantations remain the predominant agricultural crop, the susceptibility of wild Anopheles...

journal_title：Malaria journal

authors： Sadia-Kacou CMA,Alou LPA,Edi AVC,Yobo CM,Adja MA,Ouattara AF,Malone D,Koffi AA,Tano Y,Koudou BG

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom®, Odypharm Ltd), which involves treatment over two days...

journal_title：Malaria journal

authors： Menan H,Faye O,Same-Ekobo A,Oga AS,Faye B,Kiki Barro CP,Kuete T,N'diaye JL,Vicky AM,Tine R,Yavo W,Kane D,Kassi KF,Kone M

更新日期：2011-07-08 00:00:00

abstract：:The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent primary research that addresses the putative relationship between agricultural insecticide use and trends in insecticide resistance. To do so, descriptive evidence o...

journal_title：Malaria journal

authors： Reid MC,McKenzie FE

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:In formerly endemic areas where malaria transmission has declined, levels of population immunity to Plasmodium falciparum provide information on continued malaria transmission and potentially susceptible populations. Traditional techniques for measuring serological responses to P. falciparum antigens use pla...

journal_title：Malaria journal

authors： Chidi AP,Chishimba S,Kobayashi T,Hamapumbu H,Mharakurwa S,Thuma PE,Moss WJ

更新日期：2011-06-10 00:00:00

abstract：:The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

journal_title：Malaria journal

authors： Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

更新日期：2010-10-18 00:00:00

abstract：BACKGROUND:The zoonotic malaria parasite Plasmodium knowlesi has become an emerging threat to South East Asian countries particular in Malaysia. A recent study from Sarawak (Malaysian Borneo) discovered two distinct normocyte binding protein xa (Pknbpxa) types of P. knowlesi. In the present study, the Pknbpxa of clinic...

journal_title：Malaria journal

authors： Ahmed MA,Fong MY,Lau YL,Yusof R

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...

journal_title：Malaria journal

authors： Grossenbacher B,Holzschuh A,Hofmann NE,Omar KA,Stuck L,Fakih BS,Ali A,Yukich J,Hetzel MW,Felger I

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...

journal_title：Malaria journal

authors： Valencia SH,Ocampo ID,Arce-Plata MI,Recht J,Arévalo-Herrera M

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a formal health clinic, malaria overdiagnosis rates are estimated to range between 30-70%. METHODS:Thi...

journal_title：Malaria journal

authors： Hume JC,Barnish G,Mangal T,Armázio L,Streat E,Bates I

更新日期：2008-02-18 00:00:00

abstract：BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...

journal_title：Malaria journal

authors： Grande R,Antinori S,Meroni L,Menegon M,Severini C

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

journal_title：Malaria journal

authors： Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Malaria is one of the most severe global public health problems worldwide, particularly in Africa, where Nigeria has the greatest number of malaria cases. This community-based study was designed to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices ...

journal_title：Malaria journal

authors： Dawaki S,Al-Mekhlafi HM,Ithoi I,Ibrahim J,Atroosh WM,Abdulsalam AM,Sady H,Elyana FN,Adamu AU,Yelwa SI,Ahmed A,Al-Areeqi MA,Subramaniam LR,Nasr NA,Lau YL

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...

journal_title：Malaria journal

authors： Stica C,Jeffries CL,Irish SR,Barry Y,Camara D,Yansane I,Kristan M,Walker T,Messenger LA

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Appropriate case management of suspected malaria in Cambodia is critical given anti-malarial drug resistance in the region. Improving diagnosis and the use of recommended malarial treatments is a challenge in Cambodia where self-treatment and usage of drug cocktails is widespread, a notable difference from m...

journal_title：Malaria journal

authors： O'Connell KA,Samandari G,Phok S,Phou M,Dysoley L,Yeung S,Allen H,Littrell M

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko's suc...

journal_title：Malaria journal

authors： Rehman AM,Mann AG,Schwabe C,Reddy MR,Roncon Gomes I,Slotman MA,Yellott L,Matias A,Caccone A,Nseng Nchama G,Kleinschmidt I

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...

journal_title：Malaria journal

authors： Lievens M,Aponte JJ,Williamson J,Mmbando B,Mohamed A,Bejon P,Leach A

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is cor...

journal_title：Malaria journal

authors： Dhabangi A,Mworozi E,Lubega IR,Cserti-Gazdewich CM,Maganda A,Dzik WH

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Malaria is heterogeneously distributed across landscapes. Human population movement (HPM) could link sub-regions with varying levels of transmission, leading to the persistence of disease even in very low transmission settings. Malaria along the Thai-Myanmar border has been decreasing, but remains heterogene...

journal_title：Malaria journal

authors： Saita S,Pan-Ngum W,Phuanukoonnon S,Sriwichai P,Silawan T,White LJ,Parker DM

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:There is a need for accurate and field-applicable instruments for the evaluation of the quality of anti-malarial drugs. The aim of this study was to determine the diagnostic accuracy of the NanoRam(®), a handheld Raman spectrometer (RS), to identify anti-malarial drugs. METHODS:In total, 289 anti-malarial d...

journal_title：Malaria journal

authors： Visser BJ,de Vries SG,Bache EB,Meerveld-Gerrits J,Kroon D,Boersma J,Agnandji ST,van Vugt M,Grobusch MP

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...

journal_title：Malaria journal

authors： Fouque F,Gaborit P,Carinci R,Issaly J,Girod R

更新日期：2010-03-22 00:00:00