The role of extracellular vesicles in malaria biology and pathogenesis.

abstract：BACKGROUND:Passerine birds are frequently infected with diverse haemosporidian parasites. While infections are traditionally considered benign in wild birds, recent studies demonstrated mortalities of passerine species due to exo-erythrocytic development of the parasites, which can damage organs in affected hosts. Howe...

journal_title：Malaria journal

authors： Himmel T,Harl J,Pfanner S,Nedorost N,Nowotny N,Weissenböck H

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission settings or in populations on the cusp of elimination. However, most of studies are designed to contro...

journal_title：Malaria journal

authors： Sepúlveda N,Drakeley C

更新日期：2015-04-03 00:00:00

abstract：BACKGROUND:Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, containing two organoph...

journal_title：Malaria journal

authors： Mosqueira B,Chabi J,Chandre F,Akogbeto M,Hougard JM,Carnevale P,Mas-Coma S

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...

journal_title：Malaria journal

authors： Smith PH,Mwangi JM,Afrane YA,Yan G,Obbard DJ,Ranford-Cartwright LC,Little TJ

更新日期：2011-06-08 00:00:00

abstract：BACKGROUND:Early and accurate diagnosis of Plasmodium falciparum infection is important for providing appropriate treatment to patients with malaria. However, technical limitations of currently available diagnostic tests limit their use in control programs. One possible explanation for the vulnerability of current anti...

journal_title：Malaria journal

authors： Leow CH,Jones M,Cheng Q,Mahler S,McCarthy J

更新日期：2014-07-18 00:00:00

abstract：BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...

journal_title：Malaria journal

authors： Grossenbacher B,Holzschuh A,Hofmann NE,Omar KA,Stuck L,Fakih BS,Ali A,Yukich J,Hetzel MW,Felger I

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization. Safety, immunogenicity and efficacy of the RTS,S/AS02(D) vaccine candidate when integrated into a standard EPI schedul...

journal_title：Malaria journal

authors： Abdulla S,Salim N,Machera F,Kamata R,Juma O,Shomari M,Kubhoja S,Mohammed A,Mwangoka G,Aebi T,Mshinda H,Schellenberg D,Carter T,Villafana T,Dubois MC,Leach A,Lievens M,Vekemans J,Cohen J,Ballou WR,Tanner M

更新日期：2013-01-08 00:00:00

abstract：BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...

journal_title：Malaria journal

authors： Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...

journal_title：Malaria journal

authors： Pousibet-Puerto J,Salas-Coronas J,Sánchez-Crespo A,Molina-Arrebola MA,Soriano-Pérez MJ,Giménez-López MJ,Vázquez-Villegas J,Cabezas-Fernández MT

更新日期：2016-07-02 00:00:00

abstract：BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...

journal_title：Malaria journal

authors： Zikusooka CM,McIntyre D,Barnes KI

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. METHODS:An ecological study was conducted to describe the use of MDA ...

journal_title：Malaria journal

authors： Hsiang MS,Hwang J,Tao AR,Liu Y,Bennett A,Shanks GD,Cao J,Kachur SP,Feachem RG,Gosling RD,Gao Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:When discussing the relationship between meteorological factors and malaria, previous studies mainly focus on the interaction between different climatic factors, while the possible interaction within one particular climatic predictor at different lag periods has been largely neglected. In this study, this is...

journal_title：Malaria journal

authors： Wu Y,Qiao Z,Wang N,Yu H,Feng Z,Li X,Zhao X

更新日期：2017-01-31 00:00:00

abstract：BACKGROUND:A malaria vaccine based on Plasmodium falciparum apical membrane antigen 1 (AMA1) elicited strain specific efficacy in Malian children that waned in the second season after vaccination despite sustained AMA1 antibody titers. With the goal of identifying a humoral correlate of vaccine-induced protection, pre-...

journal_title：Malaria journal

authors： Berry AA,Gottlieb ER,Kouriba B,Diarra I,Thera MA,Dutta S,Coulibaly D,Ouattara A,Niangaly A,Kone AK,Traore K,Tolo Y,Mishcherkin V,Soisson L,Diggs CL,Blackwelder WC,Laurens MB,Sztein MB,Doumbo OK,Plowe CV,Lyke KE

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Malaria is a major health problem in sub-Saharan Africa where over 90% of the world's malaria cases occur. Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization as first-line and second-line treatments for uncomplicated falciparum malaria. However, there are a growing nu...

journal_title：Malaria journal

authors： Ndwigah S,Stergachis A,Abuga K,Mugo H,Kibwage I

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Programmes of pre-elimination of malaria have been implemented in Senegal since 2010, and the burden of malaria has decreased substantially. These changes in the epidemiology should be monitored with effective tools that allow changes in patterns of transmission to be estimated. In Dielmo and Ndiop, two vill...

journal_title：Malaria journal

authors： Diop F,Richard V,Diouf B,Sokhna C,Diagne N,Trape JF,Faye MM,Tall A,Diop G,Balde AT

更新日期：2014-03-06 00:00:00

abstract：:Plasmodium knowlesi is a potentially life-threatening zoonotic malaria parasite due to its relatively short erythrocytic cycle. Microscopic identification of P. knowlesi is difficult, with "compacted parasite cytoplasm" being one of the important identifying keys. This report is about a case of hyperparasitaemic human...

journal_title：Malaria journal

authors： Lee WC,Chin PW,Lau YL,Chin LC,Fong MY,Yap CJ,Supramaniam RR,Mahmud R

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

journal_title：Malaria journal

authors： Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in vitro. However, they are inflammatory and alter the permeability of the blood-brain barrier, rai...

journal_title：Malaria journal

authors： Recuenco FC,Takano R,Chiba S,Sugi T,Takemae H,Murakoshi F,Ishiwa A,Inomata A,Horimoto T,Kobayashi Y,Horiuchi N,Kato K

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiolo...

journal_title：Malaria journal

authors： Verity R,Hathaway NJ,Waltmann A,Doctor SM,Watson OJ,Patel JC,Mwandagalirwa K,Tshefu AK,Bailey JA,Ghani AC,Juliano JJ,Meshnick SR

更新日期：2018-01-24 00:00:00

abstract：BACKGROUND:The study of the Plasmodium falciparum heavy metal transporter gene pfmdr2 employed radioactive labelled heavy metal. As the use of radioactive isotopes shrank considerably during the last few years, resulting in the cessation of the production of some isotopes, amongst them Cadmium109 which was used for tha...

journal_title：Malaria journal

authors： Rosental B,Hadad U,Sinay R,Braiman A,Porgador A,Pollack Y

更新日期：2012-11-08 00:00:00

abstract：:Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...

journal_title：Malaria journal

authors： Samuels AM,Awino N,Odongo W,Abong'o B,Gimnig J,Otieno K,Shi YP,Were V,Allen DR,Were F,Sang T,Obor D,Williamson J,Hamel MJ,Patrick Kachur S,Slutsker L,Lindblade KA,Kariuki S,Desai M

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,Bottieau E,Van Esbroeck M,Bruggeman C,Jacobs J

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

journal_title：Malaria journal

authors： Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For a...

journal_title：Malaria journal

authors： de Gier B,Suryapranata FS,Croughs M,van Genderen PJ,Keuter M,Visser LG,van Vugt M,Sonder GJ

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Relatively little is known about the prevalence of blood parasites in shorebirds, especially those breeding in the tropics. The prevalence of blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon was assessed in blood samples from Kentish plovers and cream-coloured coursers in Cape Verde, ...

journal_title：Malaria journal

authors： Martínez-de la Puente J,Eberhart-Phillips LJ,Cristina Carmona-Isunza M,Zefania S,Navarro MJ,Kruger O,Hoffman JI,Székely T,Figuerola J

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:The malaria rapid diagnostic tests (RDTs) are now widely used in the world. Compared to Plasmodium falciparum, a poor sensitivity of RDTs was reported against Plasmodium vivax based on the adopted antibody against pan-Plasmodium antigen lactate dehydrogenase (pLDH) or aldolase. Levels of pLDH were measured f...

journal_title：Malaria journal

authors： Jang JW,Cho CH,Han ET,An SS,Lim CS

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Control of vivax malaria in endemic areas requires management of recurrence. The Brazilian National Malaria Surveillance System (SIVEP-Malária) records every case of malaria in Brazil, but is not designed to differentiate between primary and recurrent infections. The aim of this study was to explore whether ...

journal_title：Malaria journal

authors： Daher A,Silva JCAL,Stevens A,Marchesini P,Fontes CJ,Ter Kuile FO,Lalloo DG

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...

journal_title：Malaria journal

authors： Atemnkeng MA,De Cock K,Plaizier-Vercammen J

更新日期：2007-01-26 00:00:00

abstract：BACKGROUND:The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include outdoor biting, sub-optimal implementation and inappropriate use. New vector control interventions are required and ...

journal_title：Malaria journal

authors： Makungu C,Stephen S,Kumburu S,Govella NJ,Dongus S,Hildon ZJ,Killeen GF,Jones C

更新日期：2017-10-11 00:00:00