Evaluation of the rapid diagnostic test SDFK40 (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a non-endemic setting.

abstract：BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...

journal_title：Malaria journal

authors： Reiling SJ,Rohrbach P

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...

journal_title：Malaria journal

authors： Mikkelsen-Lopez I,Shango W,Barrington J,Ziegler R,Smith T,deSavigny D

更新日期：2014-05-11 00:00:00

abstract：:Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009-2011 and 2015-2016, Tanz...

journal_title：Malaria journal

authors： Yukich J,Stuck L,Scates S,Wisniewski J,Chacky F,Festo C,Kabulika G,Dimoso K,Mandike R,Greer G,Serbantez N,Elisaria E,Nyoni W,Dadi D,Akim I,Lengeler C,Brown N,Koenker H

更新日期：2020-04-17 00:00:00

abstract：BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...

journal_title：Malaria journal

authors： Ba H,Duffy CW,Ahouidi AD,Deh YB,Diallo MY,Tandia A,Conway DJ

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...

journal_title：Malaria journal

authors： Smith TA

更新日期：2007-05-02 00:00:00

abstract：:In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...

journal_title：Malaria journal

authors： Sampaio NG,Cheng L,Eriksson EM

更新日期：2017-06-09 00:00:00

abstract：BACKGROUND:Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS:In this study the Binax NOW Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and ...

journal_title：Malaria journal

authors： van Gool T,van Wolfswinkel ME,Koelewijn R,van Thiel PP,Jacobs J,van Hellemond JJ,van Genderen PJ

更新日期：2011-10-14 00:00:00

abstract：BACKGROUND:Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. This X-li...

journal_title：Malaria journal

authors： Dombrowski JG,Souza RM,Curry J,Hinton L,Silva NRM,Grignard L,Gonçalves LA,Gomes AR,Epiphanio S,Drakeley C,Huggett J,Clark TG,Campino S,Marinho CRF

更新日期：2017-06-15 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12936-016-1486-0.]. ...

journal_title：Malaria journal

authors： DellaValle B,Hempel C,Staalsoe T,Johansen FF,Kurtzhals JAL

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:Early and accurate diagnosis of Plasmodium falciparum infection is important for providing appropriate treatment to patients with malaria. However, technical limitations of currently available diagnostic tests limit their use in control programs. One possible explanation for the vulnerability of current anti...

journal_title：Malaria journal

authors： Leow CH,Jones M,Cheng Q,Mahler S,McCarthy J

更新日期：2014-07-18 00:00:00

abstract：BACKGROUND:Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to the last remaining at-risk places. An evaluation of the performance of surveillance systems in 16 c...

journal_title：Malaria journal

authors： Lourenço C,Tatem AJ,Atkinson PM,Cohen JM,Pindolia D,Bhavnani D,Le Menach A

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is ...

journal_title：Malaria journal

authors： Wilmot D,Ameyaw EO,Amoako-Sakyi D,Boampong JN,Quashie NB

更新日期：2017-03-04 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and house modifications are proven vector control tools, yet in most regions, full coverage has not been achieved. This study investigates household factors associated with access to ITNs and house modification in Tanzania. METHODS:Baseline cross-sectional survey data from pr...

journal_title：Malaria journal

authors： Odufuwa OG,Ross A,Mlacha YP,Juma O,Mmbaga S,Msellemu D,Moore S

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

journal_title：Malaria journal

authors： Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:Intermittent preventive (or presumptive) treatment of infants (IPTi), the administration of a curative anti-malarial dose to infants whether or not they are known to be infected, is being considered as a new strategy for malaria control. Five of the six trials using sulphadoxine-pyrimethamine (SP) for IPTi s...

journal_title：Malaria journal

authors： Gosling RD,Ghani AC,Deen JL,von Seidlein L,Greenwood BM,Chandramohan D

更新日期：2008-04-03 00:00:00

abstract：BACKGROUND:A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility-based case-control study was conducted from December 2012-July 2014. Cases (n = 107) were all patients p...

journal_title：Malaria journal

authors： Smith JL,Auala J,Haindongo E,Uusiku P,Gosling R,Kleinschmidt I,Mumbengegwi D,Sturrock HJ

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Malaria is a major public health problem in Uganda and the current policy recommends introduction of rapid diagnostic tests for malaria (RDTs) to facilitate effective case management. However, provision of RDTs in drug shops potentially raises a new set of issues, such as adherence to RDTs results, managemen...

journal_title：Malaria journal

authors： Mbonye AK,Clarke SE,Lal S,Chandler CI,Hutchinson E,Hansen KS,Magnussen P

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (PfCSP) is one of the most extensively studied malaria vaccine candidates, but the genetic polymorphism of PfCSP within and among the global P. falciparum population raises concerns regarding the efficacy of a PfCSP-based vaccine efficacy. In this study, genetic...

journal_title：Malaria journal

authors： Lê HG,Kang JM,Moe M,Jun H,Thái TL,Lee J,Myint MK,Lin K,Sohn WM,Shin HJ,Kim TS,Na BK

更新日期：2018-10-12 00:00:00

abstract：:Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...

journal_title：Malaria journal

authors： Morris CA,Duparc S,Borghini-Fuhrer I,Jung D,Shin CS,Fleckenstein L

更新日期：2011-09-13 00:00:00

abstract：:The sterile insect technique (SIT) has been shown to be an effective and sustainable genetic approach to control populations of selected major pest insects, when part of area-wide integrated pest management (AW-IPM) programmes. The technique introduces genetic sterility in females of the target population in the field...

journal_title：Malaria journal

authors： Robinson AS,Knols BG,Voigt G,Hendrichs J

更新日期：2009-11-16 00:00:00

abstract：:Spain declared the elimination of malaria in 1964. In non-endemic areas, the overwhelming majority of malaria cases are acquired abroad, and locally acquired infections are rare events. In Spain, malaria is a statutorily notifiable disease. During these fifty years more than ten thousand malaria cases have been report...

journal_title：Malaria journal

authors： Velasco E,Gomez-Barroso D,Varela C,Diaz O,Cano R

更新日期：2017-06-29 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested...

journal_title：Malaria journal

authors： Gosi P,Khusmith S,Khalambaheti T,Lanar DE,Schaecher KE,Fukuda MM,Miller SR

更新日期：2008-06-26 00:00:00

abstract：BACKGROUND:Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH-based tests become negative more quickly, but sensitivity has been reported below the recommended standard of 90%. A new pLDH test, CareS...

journal_title：Malaria journal

authors： Gerstl S,Dunkley S,Mukhtar A,De Smet M,Baker S,Maikere J

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:The importance of net durability and the average useful life of a net is increasingly recognized as one of the critical factors that determine how often nets need to be replaced. A study to assess the effect of a net care and repair behaviour change communication (BCC) programme on net durability was conduct...

journal_title：Malaria journal

authors： Helinski MH,Namara G,Koenker H,Kilian A,Hunter G,Acosta A,Scandurra L,Selby RA,Mulondo K,Fotheringham M,Lynch M

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Zooprophylaxis, the diversion of disease carrying insects from humans to animals, may reduce transmission of diseases such as malaria. However, as the number of animals increases, improved availability of blood meals may increase mosquito survival, thereby countering the impact of diverting feeds. METHODS:C...

journal_title：Malaria journal

authors： Saul A

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:Control of vivax malaria in endemic areas requires management of recurrence. The Brazilian National Malaria Surveillance System (SIVEP-Malária) records every case of malaria in Brazil, but is not designed to differentiate between primary and recurrent infections. The aim of this study was to explore whether ...

journal_title：Malaria journal

authors： Daher A,Silva JCAL,Stevens A,Marchesini P,Fontes CJ,Ter Kuile FO,Lalloo DG

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. METHODS:This study was ...

journal_title：Malaria journal

authors： Yentur Doni N,Yildiz Zeyrek F,Seyrek A

更新日期：2016-05-28 00:00:00

abstract：BACKGROUND:In many low-income countries, the private commercial sector plays an important role in the provision of malaria treatment. However, the quality of care it provides is often poor, with artemisinin combination therapy (ACT) generally being too costly for consumers. Decreasing ACT prices is critical for improvi...

journal_title：Malaria journal

authors： Patouillard E,Hanson K,Kleinschmidt I,Palafox B,Tougher S,Pok S,O'Connell K,Goodman C

更新日期：2015-05-30 00:00:00