Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays.

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women i...

journal_title：Malaria journal

authors： Mosha D,Mazuguni F,Mrema S,Sevene E,Abdulla S,Genton B

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination. There has been no report yet on the potential cardiac effects of the combination artesunate-amodiaquine. METHODS:Electrocardiographic (ECG) ...

journal_title：Malaria journal

authors： Adjei GO,Oduro-Boatey C,Rodrigues OP,Hoegberg LC,Alifrangis M,Kurtzhals JA,Goka BQ

更新日期：2012-12-17 00:00:00

abstract：BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...

journal_title：Malaria journal

authors： González C,Molina AG,León C,Salcedo N,Rondón S,Paz A,Atencia MC,Tovar C,Ortiz M

更新日期：2017-10-27 00:00:00

abstract：:The sterile insect technique (SIT) has been shown to be an effective and sustainable genetic approach to control populations of selected major pest insects, when part of area-wide integrated pest management (AW-IPM) programmes. The technique introduces genetic sterility in females of the target population in the field...

journal_title：Malaria journal

authors： Robinson AS,Knols BG,Voigt G,Hendrichs J

更新日期：2009-11-16 00:00:00

abstract：BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...

journal_title：Malaria journal

authors： Linares M,Viera S,Crespo B,Franco V,Gómez-Lorenzo MG,Jiménez-Díaz MB,Angulo-Barturen Í,Sanz LM,Gamo FJ

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including game...

journal_title：Malaria journal

authors： Bosson-Vanga H,Franetich JF,Soulard V,Sossau D,Tefit M,Kane B,Vaillant JC,Borrmann S,Müller O,Dereuddre-Bosquet N,Le Grand R,Silvie O,Mazier D

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Unde...

journal_title：Malaria journal

authors： Amegashie EA,Amenga-Etego L,Adobor C,Ogoti P,Mbogo K,Amambua-Ngwa A,Ghansah A

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epidemiological survey was conducted in September-October 2012, as a baseline underlying a 3-year popu...

journal_title：Malaria journal

authors： Rosas-Aguirre A,Guzman-Guzman M,Gamboa D,Chuquiyauri R,Ramirez R,Manrique P,Carrasco-Escobar G,Puemape C,Llanos-Cuentas A,Vinetz JM

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...

journal_title：Malaria journal

authors： Dev V,Sangma BM,Dash AP

更新日期：2010-09-22 00:00:00

abstract：BACKGROUND:An intensive effort to control malaria in Zimbabwe has produced dramatic reductions in the burden of the disease over the past 13 years. The successes have prompted the Zimbabwe's National Malaria Control Programme to commit to elimination of malaria. It is critical to analyse the changes in the morbidity tr...

journal_title：Malaria journal

authors： Sande S,Zimba M,Mberikunashe J,Tangwena A,Chimusoro A

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (mAbs) are essential tools in biological research, diagnosis and therapy, and are conventionally produced in murine hybridoma cell lines. Professional applications of mAbs depend on the steady supply of material. Because hybridoma cultures can stop producing the antibody or even die, pr...

journal_title：Malaria journal

authors： Kapelski S,Boes A,Spiegel H,de Almeida M,Klockenbring T,Reimann A,Fischer R,Barth S,Fendel R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...

journal_title：Malaria journal

authors： DaRe JT,Mehlotra RK,Michon P,Mueller I,Reeder J,Sharma YD,Stoneking M,Zimmerman PA

更新日期：2007-03-21 00:00:00

abstract：BACKGROUND:A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. METHODS:An increm...

journal_title：Malaria journal

authors： Moore BR,Davis WA,Clarke PM,Robinson LJ,Laman M,Davis TME

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Larviciding is a key strategy used in many vector control programmes around the world. Costs could be reduced if larvicides could be manufactured locally. The potential of natural products as larvicides against the main African malaria vector, Anopheles gambiae s.s was evaluated. METHODS:To assess the larvi...

journal_title：Malaria journal

authors： Okumu FO,Knols BG,Fillinger U

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...

journal_title：Malaria journal

authors： Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué F

更新日期：2012-03-16 00:00:00

abstract：BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...

journal_title：Malaria journal

authors： Valencia SH,Ocampo ID,Arce-Plata MI,Recht J,Arévalo-Herrera M

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands. And, there is a push for intensified vector control in Guadalcanal, to improve the livelihood of residents and to minimize the number of cases, which are regularly exported to the rest of the country. The...

journal_title：Malaria journal

authors： Bugoro H,Hii JL,Butafa C,Iro'ofa C,Apairamo A,Cooper RD,Chen CC,Russell TL

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Based on routine health facility case data, Rwanda has achieved a significant malaria burden reduction in the past ten years. However, community-based malaria parasitaemia burden and reasons for continued residual infections, despite a high coverage of control interventions, have yet to be characterized. Mea...

journal_title：Malaria journal

authors： Kateera F,Mens PF,Hakizimana E,Ingabire CM,Muragijemariya L,Karinda P,Grobusch MP,Mutesa L,van Vugt M

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physicall...

journal_title：Malaria journal

authors： Briet O,Koenker H,Norris L,Wiegand R,Vanden Eng J,Thackeray A,Williamson J,Gimnig JE,Fortes F,Akogbeto M,Yadouleton AW,Ombok M,Bayoh MN,Mzilahowa T,Abílio AP,Mabunda S,Cuamba N,Diouf E,Konaté L,Hamainza B,Katebe-S

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS:In February/March 2006, a survey was...

journal_title：Malaria journal

authors： Tipke M,Louis VR,Yé M,De Allegri M,Beiersmann C,Sié A,Mueller O,Jahn A

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock o...

journal_title：Malaria journal

authors： Mayagaya VS,Nkwengulila G,Lyimo IN,Kihonda J,Mtambala H,Ngonyani H,Russell TL,Ferguson HM

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robus...

journal_title：Malaria journal

authors： Pewkliang Y,Rungin S,Lerdpanyangam K,Duangmanee A,Kanjanasirirat P,Suthivanich P,Sa-Ngiamsuntorn K,Borwornpinyo S,Sattabongkot J,Patrapuvich R,Hongeng S

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample is to be obtained. Furthermo...

journal_title：Malaria journal

authors： Cham GK,Kurtis J,Lusingu J,Theander TG,Jensen AT,Turner L

更新日期：2008-06-12 00:00:00

abstract：BACKGROUND:Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts. METHODS:Sera from asymptomatic and symptomatic Plasmodium-infect...

journal_title：Malaria journal

authors： Fesel C,Goulart LF,Silva Neto A,Coelho A,Fontes CJ,Braga EM,Vaz NM

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...

journal_title：Malaria journal

authors： Okello G,Ndegwa SN,Halliday KE,Hanson K,Brooker SJ,Jones C

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Internally displaced persons (IDP) represent vulnerable populations whose public health conditions merit special attention. In the China-Myanmar border area, human movement and resettlements of IDP can influence malaria transmission. Comparison of disease incidence and vector densities between IDP camps and ...

journal_title：Malaria journal

authors： Zhou G,Lo E,Zhong D,Wang X,Wang Y,Malla S,Lee MC,Yang Z,Cui L,Yan G

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00