Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae.

abstract：BACKGROUND:Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential so...

journal_title：Malaria journal

authors： Staehli Hodel EM,Guidi M,Zanolari B,Mercier T,Duong S,Kabanywanyi AM,Ariey F,Buclin T,Beck HP,Decosterd LA,Olliaro P,Genton B,Csajka C

更新日期：2013-07-10 00:00:00

abstract：:BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...

journal_title：Malaria journal

authors： Mukabana WR,Takken W,Killeen GF,Knols BG

更新日期：2004-01-29 00:00:00

abstract：BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...

journal_title：Malaria journal

authors： Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not be...

journal_title：Malaria journal

authors： Mercado CE,Ekapirat N,Dondorp AM,Maude RJ

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:The Drugs for Neglected Diseases initiative (DNDi) is a not-for profit organization committed to providing affordable medicines and access to treatments in resource-poor settings. Traditionally drug development has happened "in house" within pharmaceutical companies, with research and development costs ultim...

journal_title：Malaria journal

authors： Wells S,Diap G,Kiechel JR

更新日期：2013-02-21 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the con...

journal_title：Malaria journal

authors： Nieto CA,Sánchez LM,Sánchez DM,Díaz GJ,Ramírez MH

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...

journal_title：Malaria journal

authors： Tougan T,Toya Y,Uchihashi K,Horii T

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs...

journal_title：Malaria journal

authors： Duah NO,Matrevi SA,de Souza DK,Binnah DD,Tamakloe MM,Opoku VS,Onwona CO,Narh CA,Quashie NB,Abuaku B,Duplessis C,Kronmann KC,Koram KA

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Challenges persist in ensuring access to and optimal use of long-lasting, insecticidal bed nets (LLINs). Factors associated with ownership and use may differ depending on the history of malaria and prevention control efforts in a specific region. Understanding how the cultural and social-environmental contex...

journal_title：Malaria journal

authors： Ernst KC,Hayden MH,Olsen H,Cavanaugh JL,Ruberto I,Agawo M,Munga S

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...

journal_title：Malaria journal

authors： Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué F

更新日期：2012-03-16 00:00:00

abstract：BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...

journal_title：Malaria journal

authors： Ng'habi KR,Mwasheshi D,Knols BG,Ferguson HM

更新日期：2010-12-08 00:00:00

abstract：:This opinion article deals with the diagnostic clinical challenges faced by clinicians or health care workers in malaria-endemic areas when a severely sick child presents to the clinic with fever, coma or respiratory distress. Indeed, the coexistence of malaria with other severe infections like meningitis, invasive ba...

journal_title：Malaria journal

authors： Ackerman H,Casals-Pascual C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:The malaria rapid diagnostic tests (RDTs) are now widely used in the world. Compared to Plasmodium falciparum, a poor sensitivity of RDTs was reported against Plasmodium vivax based on the adopted antibody against pan-Plasmodium antigen lactate dehydrogenase (pLDH) or aldolase. Levels of pLDH were measured f...

journal_title：Malaria journal

authors： Jang JW,Cho CH,Han ET,An SS,Lim CS

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...

journal_title：Malaria journal

authors： Laman M,Benjamin JM,Moore BR,Salib M,Tawat S,Davis WA,Siba PM,Robinson LJ,Davis TM

更新日期：2015-03-21 00:00:00

abstract：BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...

journal_title：Malaria journal

authors： Stica C,Jeffries CL,Irish SR,Barry Y,Camara D,Yansane I,Kristan M,Walker T,Messenger LA

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...

journal_title：Malaria journal

authors： Zikusooka CM,McIntyre D,Barnes KI

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...

journal_title：Malaria journal

authors： Pousibet-Puerto J,Salas-Coronas J,Sánchez-Crespo A,Molina-Arrebola MA,Soriano-Pérez MJ,Giménez-López MJ,Vázquez-Villegas J,Cabezas-Fernández MT

更新日期：2016-07-02 00:00:00

abstract：:The classic formulae in malaria epidemiology are reviewed that relate entomological parameters to malaria transmission, including mosquito survivorship and age-at-infection, the stability index (S), the human blood index (HBI), proportion of infected mosquitoes, the sporozoite rate, the entomological inoculation rate ...

journal_title：Malaria journal

authors： Smith DL,McKenzie FE

更新日期：2004-06-04 00:00:00

abstract：BACKGROUND:Behaviour change communication (BCC) can improve malaria prevention and treatment behaviour. As a one of the activities under Myanmar Artemisinin Resistance Containment (MARC) programme, BCC have been conducting. This study aimed to evaluate the effectiveness of the behaviour change communication and communi...

journal_title：Malaria journal

authors： Nyunt MH,Aye KM,Kyaw MP,Wai KT,Oo T,Than A,Oo HW,Phway HP,Han SS,Htun T,San KK

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Members of the Anopheles punctulatus group (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Understanding why only certain species are able to transmit malaria requires a better comprehension of ...

journal_title：Malaria journal

authors： Logue K,Chan ER,Phipps T,Small ST,Reimer L,Henry-Halldin C,Sattabongkot J,Siba PM,Zimmerman PA,Serre D

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

journal_title：Malaria journal

authors： Obbard DJ,Welch JJ,Little TJ

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. METHODS:This study was ...

journal_title：Malaria journal

authors： Yentur Doni N,Yildiz Zeyrek F,Seyrek A

更新日期：2016-05-28 00:00:00

abstract：BACKGROUND:New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in ...

journal_title：Malaria journal

authors： Yabsley MJ,Vanstreels RET,Martinsen ES,Wickson AG,Holland AE,Hernandez SM,Thompson AT,Perkins SL,West CJ,Bryan AL,Cleveland CA,Jolly E,Brown JD,McRuer D,Behmke S,Beasley JC

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Mass distribution campaigns of insecticide-treated nets for malaria prevention are usually accompanied by intensive behaviour change communication (BCC) to encourage hanging and use of nets. However, data on the effectiveness of these communication efforts are scarce. In preparation for the next round of mas...

journal_title：Malaria journal

authors： Kilian A,Lawford H,Ujuju CN,Abeku TA,Nwokolo E,Okoh F,Baba E

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Goodman CA,Snow RW

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:Relatively little is known about the prevalence of blood parasites in shorebirds, especially those breeding in the tropics. The prevalence of blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon was assessed in blood samples from Kentish plovers and cream-coloured coursers in Cape Verde, ...

journal_title：Malaria journal

authors： Martínez-de la Puente J,Eberhart-Phillips LJ,Cristina Carmona-Isunza M,Zefania S,Navarro MJ,Kruger O,Hoffman JI,Székely T,Figuerola J

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

journal_title：Malaria journal

authors： Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:An initial study of genetic diversity of Plasmodium falciparum in Asembo, western Kenya showed that the parasite maintained overall genetic stability 5 years after insecticide-treated bed net (ITN) introduction in 1997. This study investigates further the genetic diversity of P. falciparum 10 years after ini...

journal_title：Malaria journal

authors： Gatei W,Gimnig JE,Hawley W,Ter Kuile F,Odero C,Iriemenam NC,Shah MP,Howard PP,Omosun YO,Terlouw DJ,Nahlen B,Slutsker L,Hamel MJ,Kariuki S,Walker E,Shi YP

更新日期：2015-12-09 00:00:00

abstract：BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...

journal_title：Malaria journal

authors： Castberg FC,Maretty L,Staalsoe T,Hempel C,Clasen-Linde E,Hviid L,Kurtzhals JAL

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) largely account for the scale-up of malaria diagnosis in endemic settings. However, diversity in labelling including the instructions for use (IFU) limits their interchangeability and user-friendliness. Uniform, easy to follow and consistent labelling, aligned with international...

journal_title：Malaria journal

authors： Jacobs J,Barbé B,Gillet P,Aidoo M,Serra-Casas E,Van Erps J,Daviaud J,Incardona S,Cunningham J,Visser T

更新日期：2014-12-17 00:00:00