Abstract:
BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. The human antibody response to the specific Anopheles gSG6-P1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to Anopheles bites. The aim of this study was to use this biomarker to evaluate the human exposure to Anopheles mosquito bites in urban settings of Dakar (Senegal), one of the largest cities in West Africa, where Anopheles biting rates and malaria transmission are supposed to be low. METHODS:One cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown Dakar and its suburbs was performed from October to December 2008. The IgG responses to gSG6-P1 peptide have been assessed and compared to entomological data obtained in or near the same district. RESULTS:Considerable individual variations in anti-gSG6-P1 IgG levels were observed between and within districts. In spite of this individual heterogeneity, the median level of specific IgG and the percentage of immune responders differed significantly between districts. A positive and significant association was observed between the exposure levels to Anopheles gambiae bites, estimated by classical entomological methods, and the median IgG levels or the percentage of immune responders measuring the contact between human populations and Anopheles mosquitoes. Interestingly, immunological parameters seemed to better discriminate the exposure level to Anopheles bites between different exposure groups of districts. CONCLUSIONS:Specific human IgG responses to gSG6-P1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to Anopheles bites and malaria risk in low urban transmission areas. The development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings.
journal_name
Malar Jjournal_title
Malaria journalauthors
Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué Fdoi
10.1186/1475-2875-11-72subject
Has Abstractpub_date
2012-03-16 00:00:00pages
72issn
1475-2875pii
1475-2875-11-72journal_volume
11pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract::BACKGROUND: In areas of high-level, year-round malaria transmission, morbidity and mortality due to malaria decrease after the first two to three years of life. This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falcipar...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-2-37
更新日期:2003-11-05 00:00:00
abstract::Following publication of the original article [1], one of the authors has highlighted an xml-related discrepancy concerning the author group titled 'Additional Tracking Resistance to Artemisinin Collaboration authors (TRAC Group Authorship)', listed under the Acknowledgements section. ...
journal_title:Malaria journal
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12936-018-2464-5
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the na...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03550-9
更新日期:2021-01-01 00:00:00
abstract::Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1883-z
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). METHODS:In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-241
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-502
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:The Cascades region, Burkina Faso, has a high malaria burden despite reported high insecticide-treated mosquito net (ITN) use. Human and vector activities outside the hours when indoor interventions offer direct protection from infectious bites potentially increase exposure risk to bites from malaria-transmi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03538-5
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-80
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) are assumed to be simple-to-use and mobile technologies that have the capacity to standardize parasitological diagnosis for malaria across a variety of clinical settings. In order to evaluate these tests, it is important to consider how such assumptions play out in pract...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1083-2
更新日期:2016-02-05 00:00:00
abstract:BACKGROUND:Malaria caused by Plasmodium falciparum in pregnancy can result in adverse maternal and fetal sequelae. This review evaluated the adherence of the national guidelines drawn from World Health Organization (WHO) regions, Africa, Eastern Mediterranean, Southeast Asia, and Western Pacific, to the WHO recommendat...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-020-03565-2
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3057-7
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-330
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:Over the past 15 years, mortality and morbidity due to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors, Plasmodium infection in Anopheles gambiae s.l. in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1230-9
更新日期:2016-03-18 00:00:00
abstract:BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-244
更新日期:2011-08-19 00:00:00
abstract:BACKGROUND:Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relativ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2327-0
更新日期:2018-04-20 00:00:00
abstract:BACKGROUND:A previous study reported that the malaria parasite Plasmodium falciparum enters an altered growth state upon extracellular withdrawal of the essential amino acid isoleucine. Parasites slowed transit through the cell cycle when deprived of isoleucine prior to the onset of S-phase. METHODS:This project was u...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03220-w
更新日期:2020-04-08 00:00:00
abstract:BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3127-x
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-014-0537-7
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2087-2
更新日期:2017-10-30 00:00:00
abstract:BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1704-4
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falciparum. This study evaluated the transmission-blocking effect of AZM using a rodent malaria model. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-73
更新日期:2010-03-10 00:00:00
abstract::Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather th...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-13-62
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-248
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-7
更新日期:2009-01-09 00:00:00
abstract:INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-34
更新日期:2005-07-22 00:00:00
abstract:BACKGROUND:Patterns of decreasing malaria transmission intensity make presumptive treatment of malaria an unjustifiable approach in many African settings. The controlled use of anti-malarials after laboratory confirmed diagnosis is preferable in low endemic areas. Diagnosis may be facilitated by malaria rapid diagnosti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-76
更新日期:2011-04-02 00:00:00
abstract:BACKGROUND:Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-rang...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2910-z
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:The diagnosis of malaria can be difficult in non-endemic areas, such as the United States, and delays in diagnosis and errors in treatment occur too often. METHODS:A nationwide survey of laboratories in the United States and its nine dependent territories was conducted in 2010 to determine factors that may ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-340
更新日期:2011-11-10 00:00:00
abstract:BACKGROUND:Combination treatments, preferably containing an artemisinin derivative, are recommended to improve efficacy and prevent Plasmodium falciparum drug resistance. Artemether-lumefantrine (AL) and artesunate-amodiaquine (AA) are efficacious regimens that have been widely adopted in sub-Saharan Africa. However, m...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-9-335
更新日期:2010-11-22 00:00:00
abstract:BACKGROUND:Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets (ITNs) conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-102
更新日期:2013-03-18 00:00:00