Abstract:
BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging health care settings, have made them a staple in malaria control programmes. Using the setting of a pilot introduction of malaria RDTs in Greater Garissa, North Eastern Province, Kenya, this study aims to identify and understand perceptions regarding malaria diagnosis, with a particular focus on RDTs, and treatment among community members and health care workers (HCWs). METHODS:The study was conducted in five districts of Garissa County. Focus group discussions (FGD) were performed with community members that were recruited from health facilities (HFs) supported by the MENTOR Initiative. In-depth interviews (IDIs) and FGDs with HCWs were also carried out. Interview transcripts were then coded and analysed for major themes. Two researchers reviewed all codes, first separately and then together, discussed the specific categories, and finally characterized, described, and agreed upon major important themes. RESULTS:Thirty-four FGDs were carried out with a range of two to eight participants (median of four). Of 157 community members, 103 (65.6%) were women. The majority of participants were illiterate and the highest level of education was secondary school. Some 76% of participants were of Somali ethnicity. Whilst community members and HCWs demonstrated knowledge of aspects of malaria transmission, prevention, diagnosis, and treatment, gaps and misconceptions were identified. Poor adherence to negative RDT results, unfamiliarity and distrust of RDTs, and an inconsistent RDT supply were the main challenges to become apparent in FGDs and IDIs. CONCLUSION:Gaps in knowledge or incorrect beliefs exist in Greater Garissa and have the potential to act as barriers to complete and correct malaria case management. Addressing these knowledge gaps requires comprehensive education campaigns and a reliable and constant RDT supply. The results of this study highlight education and supply chain as key factors to be addressed in order to make large scale roll out of RDTs as successful and effective as possible.
journal_name
Malar Jjournal_title
Malaria journalauthors
Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan Rdoi
10.1186/1475-2875-13-502subject
Has Abstractpub_date
2014-12-17 00:00:00pages
502issn
1475-2875pii
1475-2875-13-502journal_volume
13pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:The use of artemisinin-based combination therapy (ACT) at the community level has been advocated as a means to increase access to effective antimalarial medicines by high risk groups living in underserved areas, mainly in sub-Saharan Africa. This strategy has been shown to be feasible and acceptable to the c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-190
更新日期:2008-09-27 00:00:00
abstract:BACKGROUND:Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone derivatives, synthesized through one-post reactions from primaqui...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1755-6
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Unde...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03510-3
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2875-y
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:There is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets (LLINs). Combination LLINs are designed to control susceptible and pyrethroid-resistant mosquito populations through a mixture of pyrethroid with piperonyl butoxid...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-017-2124-1
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Approximately 50 million people (60 %) live in malaria risk areas in Ethiopia, at altitudes below 2000 m. According to official data, 60-70 % of malaria cases are due to Plasmodium falciparum, and 40-30 % by Plasmodium vivax. The species Plasmodium ovale was detected in 2013 in the northwest of the country, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0893-y
更新日期:2015-09-18 00:00:00
abstract::In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihy...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-212
更新日期:2010-07-22 00:00:00
abstract::The Rethinking Malaria Leadership Forum, held at Harvard Business School in February 2017 with collaboration of the Barcelona Institute for Global Health and the Swiss Tropical and Public Health Institute, identified this training gap as a high priority for both analysis and action. The gap in human resource training ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2199-3
更新日期:2018-01-25 00:00:00
abstract:BACKGROUND:Intermittent preventive treatment in pregnancy (IPTp) delivered during antenatal care (ANC) visits has been shown to be a highly efficacious and cost-effective intervention. Given the high rates of ANC attendance in sub-Saharan Africa, the current low IPTp coverage represents considerable missed opportunitie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-440
更新日期:2014-11-20 00:00:00
abstract:BACKGROUND:The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). METHODS:This study was a series of qualit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-220
更新日期:2012-07-02 00:00:00
abstract:BACKGROUND:Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to the last remaining at-risk places. An evaluation of the performance of surveillance systems in 16 c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2960-2
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2087-2
更新日期:2017-10-30 00:00:00
abstract:BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-163
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-192
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2759-1
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1842-8
更新日期:2017-05-02 00:00:00
abstract:BACKGROUND:Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-47
更新日期:2010-02-11 00:00:00
abstract:BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1188-7
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-356
更新日期:2014-09-10 00:00:00
abstract::India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-019-3011-8
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-174
更新日期:2008-09-11 00:00:00
abstract:BACKGROUND:Anti-malarial drugs are an important tool for malaria control and elimination. Alongside their direct benefit in the treatment of disease, drug use has a community-level effect, clearing the reservoir of infection and reducing onward transmission of the parasite. Different compounds potentially have differen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1988-4
更新日期:2017-08-16 00:00:00
abstract:BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-86
更新日期:2014-03-10 00:00:00
abstract:BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-457
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03253-1
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-1012-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:Immunization with attenuated malaria sporozoites protects humans from experimental malaria challenge by mosquito bite. Protection in humans is strongly correlated with the production of T cells targeting a heterogeneous population of pre-erythrocyte antigen proteoforms, including liver stage antigens. Curren...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3093-3
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND:A previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western Kenya. The present follow-up study determines whether there is a relationship between the mosquito's preferences and its survival and fecundity. METHO...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-113
更新日期:2007-08-21 00:00:00
abstract::Following publication of the original article [1], one of the authors has highlighted an xml-related discrepancy concerning the author group titled 'Additional Tracking Resistance to Artemisinin Collaboration authors (TRAC Group Authorship)', listed under the Acknowledgements section. ...
journal_title:Malaria journal
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12936-018-2464-5
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria. METHODS:Filter-paper blo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2977-6
更新日期:2019-10-07 00:00:00