Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine.

abstract：BACKGROUND:Monitoring and evaluation of malaria programmes may require a combination of approaches to detect any effects of control. This is particularly true at lower transmission levels where detecting both infection and exposure to infection will provide additional evidence of any change. This paper describes use of...

journal_title：Malaria journal

authors： Stevenson JC,Stresman GH,Baidjoe A,Okoth A,Oriango R,Owaga C,Marube E,Bousema T,Cox J,Drakeley C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-base...

journal_title：Malaria journal

authors： Mnyone LL,Lyimo IN,Lwetoijera DW,Mpingwa MW,Nchimbi N,Hancock PA,Russell TL,Kirby MJ,Takken W,Koenraadt CJ

更新日期：2012-03-26 00:00:00

abstract：BACKGROUND:Deltamethrin-impregnated, long-lasting insecticidal nets (LLINs) were distributed in the study area from November 2014 to January 2015 to evaluate their impact on malaria transmission in the presence of insecticide-resistant vectors. Studies were carried out in 16 selected clusters in Keshkal sub-district, C...

journal_title：Malaria journal

authors： Kona MP,Kamaraju R,Donnelly MJ,Bhatt RM,Nanda N,Chourasia MK,Swain DK,Suman S,Uragayala S,Kleinschmidt I,Pandey V

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...

journal_title：Malaria journal

authors： Linares M,Viera S,Crespo B,Franco V,Gómez-Lorenzo MG,Jiménez-Díaz MB,Angulo-Barturen Í,Sanz LM,Gamo FJ

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:T1BT* is a peptide construct containing the T1 and B epitopes located in the 5' minor repeat and the 3' major repeat of the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP), respectively, and the universal T* epitope located in the C-terminus of the same protein. This peptide...

journal_title：Malaria journal

authors： Topchiy E,Armstrong GS,Boswell KI,Buchner GS,Kubelka J,Lehmann TE

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region. Ghana adopted the WH...

journal_title：Malaria journal

authors： Nonvignon J,Aryeetey GC,Issah S,Ansah P,Malm KL,Ofosu W,Tagoe T,Agyemang SA,Aikins M

更新日期：2016-07-16 00:00:00

abstract：BACKGROUND:Post-malaria neurological syndrome (PMNS) is a debated entity, defined by neurological complications following a post-malaria symptom-free period and a negative blood smear. Four cases of PMNS are hereby reported and a review the literature performed to clarify the nosological framework of this syndrome. ME...

journal_title：Malaria journal

authors： Tamzali Y,Demeret S,Haddad E,Guillot H,Caumes E,Jauréguiberry S

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Helminths and malaria are among the most prevalent infectious diseases in the world. They both occur in tropical area where they often affect the same populations. There are studies suggesting an effect of helminths on malariometric indices. For example, malaria attacks as well as disease severity has been s...

journal_title：Malaria journal

authors： Ateba-Ngoa U,Adegnika AA,Zinsou JF,Kassa Kassa RF,Smits H,Massinga-Loembe M,Mordmüller B,Kremsner PG,Yazdanbakhsh M

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Dihydroartemisinin (DHA) is a component of artemisinin-based combination therapy (ACT), which is widely recommended for treatment of uncomplicated falciparum malaria. DHA is also the main metabolite of artemether and artesunate, both of which are used in ACT. Due to auto-induction metabolism, declining plasm...

journal_title：Malaria journal

authors： Zang M,Zhu F,Zhao L,Yang A,Li X,Liu H,Xing J

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Mosquito larval control may prove to be an effective tool for incorporating into integrated vector management (IVM) strategies for reducing malaria transmission. Here the efficacy of microbial larvicides against Anopheles gambiae s.l. was tested in preparation for a large-scale larviciding programme in The G...

journal_title：Malaria journal

authors： Majambere S,Lindsay SW,Green C,Kandeh B,Fillinger U

更新日期：2007-06-07 00:00:00

abstract：BACKGROUND:Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. This report describes the immunological characterization of linear and cycliz...

journal_title：Malaria journal

authors： Tamborrini M,Mueller MS,Stoffel SA,Westerfeld N,Vogel D,Boato F,Zurbriggen R,Robinson JA,Pluschke G

更新日期：2009-12-30 00:00:00

abstract：:The outcomes from recent high profile deliberations concerning African health research and economic development all point towards the need for a mechanism to support health innovation on the continent. The mission of the African Network for Drugs and Diagnostics Innovation (ANDI), is to promote and sustain African-led...

journal_title：Malaria journal

authors： Addae-Mensah I,Fakorede F,Holtel A,Nwaka S

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...

journal_title：Malaria journal

authors： Buregyeya E,Rutebemberwa E,LaRussa P,Lal S,Clarke SE,Hansen KS,Magnussen P,Mbonye AK

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS:Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-bi...

journal_title：Malaria journal

authors： Teo A,Hasang W,Randall LM,Unger HW,Siba PM,Mueller I,Brown GV,Rogerson SJ

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria, but may probably also worsen the severity of imported cases. The ...

journal_title：Malaria journal

authors： Vliegenthart-Jongbloed K,de Mendonça Melo M,van Wolfswinkel ME,Koelewijn R,van Hellemond JJ,van Genderen PJ

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Malaria is a leading global cause of preventable morbidity and mortality, especially in sub-Saharan Africa, despite recent advances in treatment and prevention technologies. Scale-up and wide distribution of long-lasting insecticide-treated nets (LLINs) could rapidly decrease malarial disease in endemic area...

journal_title：Malaria journal

authors： Dye TD,Apondi R,Lugada ES,Kahn JG,Smith J,Othoro C

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost, poor availability, and technical difficulty. With the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analys...

journal_title：Malaria journal

authors： Kafsack BF,Painter HJ,Llinás M

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, ...

journal_title：Malaria journal

authors： Pribluda VS,Barojas A,Añez A,López CG,Figueroa R,Herrera R,Nakao G,Nogueira FH,Pianetti GA,Povoa MM,Viana GM,Gomes MS,Escobar JP,Sierra OL,Norena SP,Veloz R,Bravo MS,Aldás MR,Hindssemple A,Collins M,Ceron N,Kris

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND:The resistance of malaria parasites to sulphadoxine-pyrimethamine (SP) in 2007 led to the Malawi Ministry of Health changing to artemether-lumefantrine (AL) as first-line for uncomplicated malaria treatment. This study determined the efficacy and safety of AL for the treatment of uncomplicated Plasmodium fal...

journal_title：Malaria journal

authors： Dambe R,Sande J,Ali D,Chilima B,Dodoli W,Michelo C,Malenga G,Phiri KS

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-rang...

journal_title：Malaria journal

authors： Rondón S,León C,Link A,González C

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a formal health clinic, malaria overdiagnosis rates are estimated to range between 30-70%. METHODS:Thi...

journal_title：Malaria journal

authors： Hume JC,Barnish G,Mangal T,Armázio L,Streat E,Bates I

更新日期：2008-02-18 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the con...

journal_title：Malaria journal

authors： Nieto CA,Sánchez LM,Sánchez DM,Díaz GJ,Ramírez MH

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Zoonotic infections with epidemic potential, as non-human primate malaria and yellow fever (YF), can overlap geographically. Optimizing a small blood sample for diagnosis and surveillance is of great importance. Blood are routinely collected for YF diagnosis and blood clots usually discarded after serum obte...

journal_title：Malaria journal

authors： de Abreu FVS,Gomes LR,Mello ARL,Bianco-Júnior C,de Pina-Costa A,Dos Santos E,Teixeira DS,Brasil P,Daniel-Ribeiro CT,Lourenço-de-Oliveira R,de Fátima Ferreira-da-Cruz M

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...

journal_title：Malaria journal

authors： Ishengoma DS,Lwitiho S,Madebe RA,Nyagonde N,Persson O,Vestergaard LS,Bygbjerg IC,Lemnge MM,Alifrangis M

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:In view of the close relationship of Portugal with African countries, particularly former Portuguese colonies, the diagnosis of malaria is not a rare thing. When a traveller returns ill from endemic areas, malaria should be the number one suspect. World Health Organization treatment guidelines recommend that...

journal_title：Malaria journal

authors： Santos LC,Abreu CF,Xerinda SM,Tavares M,Lucas R,Sarmento AC

更新日期：2012-03-29 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...

journal_title：Malaria journal

authors： Dow GS,Gettayacamin M,Hansukjariya P,Imerbsin R,Komcharoen S,Sattabongkot J,Kyle D,Milhous W,Cozens S,Kenworthy D,Miller A,Veazey J,Ohrt C

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin wer...

journal_title：Malaria journal

authors： Antonio-Nkondjio C,Tene Fossog B,Kopya E,Poumachu Y,Menze Djantio B,Ndo C,Tchuinkam T,Awono-Ambene P,Wondji CS

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of...

journal_title：Malaria journal

authors： Ntamabyaliro NY,Burri C,Nzolo DB,Engo AB,Lula YN,Mampunza SM,Nsibu CN,Mesia GK,Kayembe JN,Likwela JL,Kintaudi LM,Tona GL

更新日期：2018-05-03 00:00:00