Traditional medicines as a mechanism for driving research innovation in Africa.

abstract：BACKGROUND:Rapid elimination of Plasmodium falciparum malaria in Cambodia is a goal with both national and international significance. Transmission of malaria in Cambodia is limited to forest environments, and the main population at risk consists of forest-goers who rely on forest products for income or sustenance. The...

journal_title：Malaria journal

authors： Kunkel A,Nguon C,Iv S,Chhim S,Peov D,Kong P,Kim S,Im S,Debackere M,Khim N,Popovici J,Srun S,Vantaux A,Guintran JO,Witkowski B,Piola P

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

journal_title：Malaria journal

authors： Baton LA,Ranford-Cartwright LC

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...

journal_title：Malaria journal

authors： Cator LJ,Thomas S,Paaijmans KP,Ravishankaran S,Justin JA,Mathai MT,Read AF,Thomas MB,Eapen A

更新日期：2013-03-02 00:00:00

abstract：:The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

journal_title：Malaria journal

authors： Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

更新日期：2010-10-18 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDT) and real-time PCR (qPCR) assays are sensitive for diagnosing malaria, but because they detect antigen and DNA, respectively, positivity may not reflect active infection. Performance characteristics of RDT and qPCR in Plasmodium falciparum positive specimens were evaluated over ti...

journal_title：Malaria journal

authors： Phuong M,Lau R,Ralevski F,Boggild AK

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria. METHODS:Filter-paper blo...

journal_title：Malaria journal

authors： Ikegbunam MN,Nkonganyi CN,Thomas BN,Esimone CO,Velavan TP,Ojurongbe O

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Zoonotic infections with epidemic potential, as non-human primate malaria and yellow fever (YF), can overlap geographically. Optimizing a small blood sample for diagnosis and surveillance is of great importance. Blood are routinely collected for YF diagnosis and blood clots usually discarded after serum obte...

journal_title：Malaria journal

authors： de Abreu FVS,Gomes LR,Mello ARL,Bianco-Júnior C,de Pina-Costa A,Dos Santos E,Teixeira DS,Brasil P,Daniel-Ribeiro CT,Lourenço-de-Oliveira R,de Fátima Ferreira-da-Cruz M

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining interventions provides added benefit in reducing mortality and morbidity from malaria. The potential benefits of combining IPT in children (IPTc) with ho...

journal_title：Malaria journal

authors： Sesay S,Milligan P,Touray E,Sowe M,Webb EL,Greenwood BM,Bojang KA

更新日期：2011-01-07 00:00:00

abstract：BACKGROUND:Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle. Thus, a better understanding of which individuals constitute the primary gametocyte reservoir within an endemic population, and the temporal dy...

journal_title：Malaria journal

authors： Adomako-Ankomah Y,Chenoweth MS,Tocker AM,Doumbia S,Konate D,Doumbouya M,Keita AS,Anderson JM,Fairhurst RM,Diakite M,Miura K,Long CA

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Avian malaria vector competence studies are needed to understand more succinctly complex avian parasite-vector-relations. The lack of vector competence trials may be attributed to the difficulty of obtaining gametocytes for the majority of Plasmodium species and lineages. To conduct avian malaria infectivity...

journal_title：Malaria journal

authors： Carlson JS,Giannitti F,Valkiūnas G,Tell LA,Snipes J,Wright S,Cornel AJ

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...

journal_title：Malaria journal

authors： Kattenberg JH,Erhart A,Truong MH,Rovira-Vallbona E,Vu KAD,Nguyen THN,Nguyen VH,Nguyen VV,Bannister-Tyrrell M,Theisen M,Bennet A,Lover AA,Tran TD,Nguyen XX,Rosanas-Urgell A

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...

journal_title：Malaria journal

authors： Okell LC,Paintain LS,Webster J,Hanson K,Lines J

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Molecular tools for detection of low-density asymptomatic Plasmodium infections are needed in malaria elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic malaria in Zanzibar. ...

journal_title：Malaria journal

authors： Morris U,Khamis M,Aydin-Schmidt B,Abass AK,Msellem MI,Nassor MH,González IJ,Mårtensson A,Ali AS,Björkman A,Cook J

更新日期：2015-05-17 00:00:00

abstract：BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...

journal_title：Malaria journal

authors： Setyadi A,Arguni E,Kenangalem E,Hasanuddin A,Lampah DA,Thriemer K,Anstey NM,Sugiarto P,Simpson JA,Price RN,Douglas NM,Poespoprodjo JR

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Malaria control largely depends on availability of highly efficacious drugs, however, over the years, has been threatened by emergence of drug resistance. It is, therefore, important to monitor the impact of recurrent anti-malarial treatment on the long-term efficacy of anti-malarial regimens, especially in ...

journal_title：Malaria journal

authors： Byakika-Kibwika P,Nyakato P,Lamorde M,Kiragga AN

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization. Safety, immunogenicity and efficacy of the RTS,S/AS02(D) vaccine candidate when integrated into a standard EPI schedul...

journal_title：Malaria journal

authors： Abdulla S,Salim N,Machera F,Kamata R,Juma O,Shomari M,Kubhoja S,Mohammed A,Mwangoka G,Aebi T,Mshinda H,Schellenberg D,Carter T,Villafana T,Dubois MC,Leach A,Lievens M,Vekemans J,Cohen J,Ballou WR,Tanner M

更新日期：2013-01-08 00:00:00

abstract：BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...

journal_title：Malaria journal

authors： Verma G,Surolia N

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:The objective of this project was to achieve high, sustainable levels of net coverage in a village in rural Tanzania by combining free distribution of long-lasting insecticide-impregnated nets (LLINs) with community-tailored education. In Tanzania, malaria is the leading cause of morbidity and mortality. Alt...

journal_title：Malaria journal

authors： Widmar M,Nagel CJ,Ho DY,Benziger PW,Hennig N

更新日期：2009-12-31 00:00:00

abstract：BACKGROUND:Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robus...

journal_title：Malaria journal

authors： Pewkliang Y,Rungin S,Lerdpanyangam K,Duangmanee A,Kanjanasirirat P,Suthivanich P,Sa-Ngiamsuntorn K,Borwornpinyo S,Sattabongkot J,Patrapuvich R,Hongeng S

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the na...

journal_title：Malaria journal

authors： Mahaman Moustapha L,Adamou R,Ibrahim ML,Abdoulaye Louis Padounou M,Diallo A,Courtin D,Testa J,Ndiaye JLA

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Modelling risk of malaria in longitudinal studies is common, because individuals are at risk for repeated infections over time. Malaria infections result in acquired immunity to clinical malaria disease. Prospective cohorts are an ideal design to relate the historical exposure to infection and development of...

journal_title：Malaria journal

authors： Stanley CC,Kazembe LN,Mukaka M,Otwombe KN,Buchwald AG,Hudgens MG,Mathanga DP,Laufer MK,Chirwa TF

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria whe...

journal_title：Malaria journal

authors： Njokah MJ,Kang'ethe JN,Kinyua J,Kariuki D,Kimani FT

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:This paper reports on the availability of diagnostic tools and recommended anti-malarials in the 12-month period immediately following the implementation of a new national malaria treatment protocol (NMTP) in Papua New Guinea (PNG). Health worker adherence to the new NMTP is also examined and comparisons mad...

journal_title：Malaria journal

authors： Pulford J,Kurumop SF,Ura Y,Siba PM,Mueller I,Hetzel MW

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets (ITNs) conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the...

journal_title：Malaria journal

authors： Sedlmayr R,Fink G,Miller JM,Earle D,Steketee RW

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...

journal_title：Malaria journal

authors： Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify urinary biomarkers of falciparum malaria. METHODS:The study used a ca...

journal_title：Malaria journal

authors： Abdelrazig S,Ortori CA,Davey G,Deressa W,Mulleta D,Barrett DA,Amberbir A,Fogarty AW

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:The counterfeiting of anti-malarials represents a form of attack on global public health in which fake and substandard anti-malarials serve as de facto weapons of mass destruction, particularly in resource-constrained endemic settings, where malaria causes nearly 660,000 preventable deaths and threatens mill...

journal_title：Malaria journal

authors： Karunamoorthi K

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:Five species of Plasmodium are known to infect humans. For proper treatment of malaria, accurate identification of the parasite species is crucial. The current gold standard for malaria diagnosis is microscopic examination of Giemsa-stained blood smears. Since the parasite species are identified by microscop...

journal_title：Malaria journal

authors： Hashimoto M,Sakamoto H,Ido Y,Tanaka M,Yatsushiro S,Kajimoto K,Kataoka M

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relativ...

journal_title：Malaria journal

authors： Olupot-Olupot P,Eregu EIE,Naizuli K,Ikiror J,Acom L,Burgoine K

更新日期：2018-04-20 00:00:00

abstract：BACKGROUND:Knowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the geneti...

journal_title：Malaria journal

authors： Maneerattanasak S,Gosi P,Krudsood S,Tongshoob J,Lanteri CA,Snounou G,Khusmith S

更新日期：2016-02-09 00:00:00