A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case-control study.

abstract：BACKGROUND:Falciparum malaria remains a major occupational illness that accounts for several deaths per year and numerous lost working days among the expatriate population, working or living in high-risk malarious areas. Compliance to preventive strategies is poor in travellers, especially business travellers, expatria...

journal_title：Malaria journal

authors： Roukens AH,Berg J,Barbey A,Visser LG

更新日期：2008-07-14 00:00:00

abstract：BACKGROUND:Obtaining single parasite clones is required for many techniques in malaria research. Cloning by limiting dilution using microscopy-based assessment for parasite growth is an arduous and labor-intensive process. An alternative method for the detection of parasite growth in limiting dilution assays is using a...

journal_title：Malaria journal

authors： Butterworth AS,Robertson AJ,Ho MF,Gatton ML,McCarthy JS,Trenholme KR

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition...

journal_title：Malaria journal

authors： Zhao X,Chen F,Feng Z,Li X,Zhou XH

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...

journal_title：Malaria journal

authors： Fortpied J,Collignon S,Moniotte N,Renaud F,Bayat B,Lemoine D

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...

journal_title：Malaria journal

authors： Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...

journal_title：Malaria journal

authors： Gore-Langton GR,Mungai J,Alenwi N,Abagira A,Bicknell OM,Harrison R,Hassan FA,Munga S,Njoroge F,Juma E,Allan R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...

journal_title：Malaria journal

authors： Nyakoe NK,Taylor RP,Makumi JN,Waitumbi JN

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:A previous study reported that the malaria parasite Plasmodium falciparum enters an altered growth state upon extracellular withdrawal of the essential amino acid isoleucine. Parasites slowed transit through the cell cycle when deprived of isoleucine prior to the onset of S-phase. METHODS:This project was u...

journal_title：Malaria journal

authors： McLean KJ,Jacobs-Lorena M

更新日期：2020-04-08 00:00:00

abstract：:Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades. Despite this, there is currently no licensed malaria vaccine. Research...

journal_title：Malaria journal

authors： Mwangoka G,Ogutu B,Msambichaka B,Mzee T,Salim N,Kafuruki S,Mpina M,Shekalaghe S,Tanner M,Abdulla S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increas...

journal_title：Malaria journal

authors： Bruce MC,Macheso A,McConnachie A,Molyneux ME

更新日期：2011-02-11 00:00:00

abstract：:BACKGROUND: The development of Plasmodium falciparum within human erythrocytes induces a wide array of changes in the ultrastructure, function and antigenic properties of the host cell. Numerous proteins encoded by the parasite have been shown to interact with the erythrocyte membrane. The identification of new intera...

journal_title：Malaria journal

authors： Lauterbach SB,Lanzillotti R,Coetzer TL

更新日期：2003-12-17 00:00:00

abstract：BACKGROUND:In a previous study, severe and cerebral malaria have been connected with acute cochlear malfunction in children, demonstrated by a decrease of transitory evoked otoacoustic emissions (TEOAEs) reproducibility. This study aims to determine whether cochlear malfunction persists for 4 years after recovery from ...

journal_title：Malaria journal

authors： Reiterer E,Reider S,Lackner P,Fischer N,Dejaco D,Riechelmann H,Zorowka P,Kremsner PG,Adegnika AA,Schmutzhard E,Schmutzhard J

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Slash and burn cultivators are a significant risk group for malaria in South-East Asia. As envisaged in the National Strategic Plan for Malaria Elimination, Bangladesh aims to achieve zero indigenous malaria transmission by 2030. For the national plan to move from malaria control to malaria elimination, targ...

journal_title：Malaria journal

authors： Saha A,Sarker M,Kabir M,Lu G,Müller O

更新日期：2019-06-25 00:00:00

abstract：BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...

journal_title：Malaria journal

authors： Culleton RL,Mita T,Ndounga M,Unger H,Cravo PV,Paganotti GM,Takahashi N,Kaneko A,Eto H,Tinto H,Karema C,D'Alessandro U,do Rosário V,Kobayakawa T,Ntoumi F,Carter R,Tanabe K

更新日期：2008-09-11 00:00:00

abstract：BACKGROUND:Molecular tools for detection of low-density asymptomatic Plasmodium infections are needed in malaria elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic malaria in Zanzibar. ...

journal_title：Malaria journal

authors： Morris U,Khamis M,Aydin-Schmidt B,Abass AK,Msellem MI,Nassor MH,González IJ,Mårtensson A,Ali AS,Björkman A,Cook J

更新日期：2015-05-17 00:00:00

abstract：BACKGROUND:Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion (GMS). The Plasmodium vivax parasite population has experienced varying drug pressure dependent ...

journal_title：Malaria journal

authors： Duanguppama J,Mathema VB,Tripura R,Day NPJ,Maxay M,Nguon C,von Seidlein L,Dhorda M,Peto TJ,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...

journal_title：Malaria journal

authors： Grande R,Antinori S,Meroni L,Menegon M,Severini C

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium falciparum in pregnancy can result in adverse maternal and fetal sequelae. This review evaluated the adherence of the national guidelines drawn from World Health Organization (WHO) regions, Africa, Eastern Mediterranean, Southeast Asia, and Western Pacific, to the WHO recommendat...

journal_title：Malaria journal

authors： Al Khaja KAJ,Sequeira RP

更新日期：2021-01-23 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...

journal_title：Malaria journal

authors： Magesa SM,Lengeler C,deSavigny D,Miller JE,Njau RJ,Kramer K,Kitua A,Mwita A

更新日期：2005-07-22 00:00:00

abstract：BACKGROUND:Public health pesticides has been the mainstay control of vectors of malaria and other diseases, and public health pests, but there is increasing concern over how these pesticides are being managed. Poor pesticide management could lead to risks to human health and the environment, or diminish the effectivene...

journal_title：Malaria journal

authors： van den Berg H,Yadav RS,Zaim M

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...

journal_title：Malaria journal

authors： Srisutham S,Suwannasin K,Mathema VB,Sriprawat K,Smithuis FM,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors and malaria prevalence in Indonesia. METHODS:The study used a cross-sectional design and analysed re...

journal_title：Malaria journal

authors： Hasyim H,Dale P,Groneberg DA,Kuch U,Müller R

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robus...

journal_title：Malaria journal

authors： Pewkliang Y,Rungin S,Lerdpanyangam K,Duangmanee A,Kanjanasirirat P,Suthivanich P,Sa-Ngiamsuntorn K,Borwornpinyo S,Sattabongkot J,Patrapuvich R,Hongeng S

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women i...

journal_title：Malaria journal

authors： Mosha D,Mazuguni F,Mrema S,Sevene E,Abdulla S,Genton B

更新日期：2014-05-27 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12936-016-1486-0.]. ...

journal_title：Malaria journal

authors： DellaValle B,Hempel C,Staalsoe T,Johansen FF,Kurtzhals JAL

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...

journal_title：Malaria journal

authors： Zhu L,Marshall JM,Qualls WA,Schlein Y,McManus JW,Arheart KL,Hlaing WM,Traore SF,Doumbia S,Müller GC,Beier JC

更新日期：2015-12-08 00:00:00