Abstract:
BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition to mean temperatures, daily fluctuations in temperature can affect essential mosquito and parasite traits that determine malaria transmission intensity. However, so far there is no epidemiological evidence at the population level to this problem. METHODS:Thirty counties in southwest China were selected, and corresponding weekly malaria cases and weekly meteorological variables were collected from 2004 to 2009. Particularly, maximum, mean and minimum temperatures were collected. The daily temperature fluctuation was measured by the diurnal temperature range (DTR), the difference between the maximum and minimum temperature. The distributed lag non-linear model (MDLNM) was used to study the correlation between weekly malaria incidences and weekly mean temperatures, and the correlation pattern was allowed to vary over different levels of daily temperature fluctuations. RESULTS:The overall non-linear patterns for mean temperatures are distinct across different levels of DTR. When under cooler temperature conditions, the larger mean temperature effect on malaria incidences is found in the groups of higher DTR, suggesting that large daily temperature fluctuations act to speed up the malaria incidence in cooler environmental conditions. In contrast, high daily fluctuations under warmer conditions will lead to slow down the mean temperature effect. Furthermore, in the group of highest DTR, 24-25°C or 21-23°C are detected as the optimal temperature for the malaria transmission. CONCLUSION:The environment is rarely constant, and the result highlights the need to consider temperature fluctuations as well as mean temperatures, when trying to understand or predict malaria transmission. This work may be the first epidemiological study confirming that the effect of the mean temperature depends on temperature fluctuations, resulting in relevant evidence at the population level.
journal_name
Malar Jjournal_title
Malaria journalauthors
Zhao X,Chen F,Feng Z,Li X,Zhou XHdoi
10.1186/1475-2875-13-192subject
Has Abstractpub_date
2014-05-27 00:00:00pages
192issn
1475-2875pii
1475-2875-13-192journal_volume
13pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Control of mosquitoes requires the ability to evaluate new insecticides and to monitor resistance to existing insecticides. Monitoring tools should be flexible and low cost so that they can be deployed in remote, resource poor areas. Ideally, a bioassay should be able to simulate transient contact between mo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-499
更新日期:2014-12-16 00:00:00
abstract:BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-015-0624-4
更新日期:2015-03-21 00:00:00
abstract:BACKGROUND:Subsistence rice farmers in south-eastern Tanzania are often migratory, spending weeks or months tending to crops in distant fields along the river valleys and living in improvised structures known as Shamba huts, not fully protected from mosquitoes. These farmers also experience poor access to organized pre...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1616-8
更新日期:2016-11-22 00:00:00
abstract::BACKGROUND: The development of Plasmodium falciparum within human erythrocytes induces a wide array of changes in the ultrastructure, function and antigenic properties of the host cell. Numerous proteins encoded by the parasite have been shown to interact with the erythrocyte membrane. The identification of new intera...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-2-47
更新日期:2003-12-17 00:00:00
abstract:BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-320
更新日期:2013-09-13 00:00:00
abstract:BACKGROUND:Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential so...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-235
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. This report describes the immunological characterization of linear and cycliz...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-314
更新日期:2009-12-30 00:00:00
abstract:BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-9-122
更新日期:2010-05-12 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1750-y
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Advances in digitized video-tracking and behavioural analysis have enabled accurate recording and quantification of mosquito flight and host-seeking behaviours, facilitating development of individual (agent) based models at much finer spatial scales than previously possible. METHODS:Quantified behavioural p...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03546-5
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Health care demand studies help to examine the behaviour of individuals and households during illnesses. Few of existing health care demand studies examine the choice of treatment services for childhood illnesses. Besides, in their analyses, many of the existing studies compare alternative treatment options ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-188
更新日期:2010-06-28 00:00:00
abstract:BACKGROUND:Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS:Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-bi...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-015-0736-x
更新日期:2015-05-26 00:00:00
abstract:BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-80
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:Within the context of combined interventions, malaria vaccine may provide additional value in malaria prevention. Stakeholders' perspectives are thus critical for informed recommendation of the vaccine in Tanzania. This paper presents the views of stakeholders with regards to malaria vaccine in 12 Tanzanian ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1209-6
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:This analysis examined how the proportion of children less than 5-years-old who slept under a bed net the previous night changed during and after a national long-lasting insecticidal net (LLIN) distribution campaign in Sierra Leone in November-December 2010. METHODS:A citywide cross-sectional study in 2010-...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0990-y
更新日期:2015-11-18 00:00:00
abstract:BACKGROUND:The widespread use of indoor-based malaria vector control interventions has been shown to alter the behaviour of vectors in Africa. There is an increasing concern that such changes could sustain residual transmission. This study was conducted to assess vector species composition, feeding behaviour and their ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2098-z
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-251
更新日期:2009-11-05 00:00:00
abstract:BACKGROUND:Malaria is a major public health problem in Uganda and the current policy recommends introduction of rapid diagnostic tests for malaria (RDTs) to facilitate effective case management. However, provision of RDTs in drug shops potentially raises a new set of issues, such as adherence to RDTs results, managemen...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-015-0979-6
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-394
更新日期:2012-11-28 00:00:00
abstract:BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-7-242
更新日期:2008-11-23 00:00:00
abstract:BACKGROUND:Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS:Using a rodent malaria model system...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-12
更新日期:2004-05-19 00:00:00
abstract::BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-1
更新日期:2004-01-29 00:00:00
abstract:BACKGROUND:Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the public, providing many novel chemical starting points for anti-malarial drug disco...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-424
更新日期:2013-11-16 00:00:00
abstract:BACKGROUND:Most of the current biophysical models designed to address the large-scale distribution of malaria assume that transmission of the disease is independent of the vector involved. Another common assumption in these type of model is that the mortality rate of mosquitoes is constant over their life span and that...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-28
更新日期:2013-01-23 00:00:00
abstract:BACKGROUND:The United Nation's sustainable development goal for 2030 is to eradicate the global malaria epidemic, primarily as the disease continues to be one of the major concerns for public health in sub-Saharan Africa. In 2015, the region accounted for 90% of malaria deaths. Mozambique recorded a malaria mortality r...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1866-0
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-160
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:The diagnosis of malaria can be difficult in non-endemic areas, such as the United States, and delays in diagnosis and errors in treatment occur too often. METHODS:A nationwide survey of laboratories in the United States and its nine dependent territories was conducted in 2010 to determine factors that may ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-340
更新日期:2011-11-10 00:00:00
abstract:BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-8-196
更新日期:2009-08-12 00:00:00
abstract:BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-475
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such an assay could be used to distinguish recrudescence from re-infection in drug trials, to monitor...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-223
更新日期:2008-10-29 00:00:00