Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection.

abstract：BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Goodman CA,Snow RW

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:Drug and multidrug-resistant Plasmodium falciparum malaria has existed in Thailand for several decades. Furthermore, Thailand serves as a sentinel for drug-resistant malaria within the Greater Mekong sub-region. However, the drug resistance situation is highly dynamic, changing quickly over time. Here parasi...

journal_title：Malaria journal

authors： Parker D,Lerdprom R,Srisatjarak W,Yan G,Sattabongkot J,Wood J,Sirichaisinthop J,Cui L

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...

journal_title：Malaria journal

authors： Sylla M,Kobylinski KC,Gray M,Chapman PL,Sarr MD,Rasgon JL,Foy BD

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quality anti-malarials directly affect health outcomes by increasing malaria morbidity and mortality, as ...

journal_title：Malaria journal

authors： Ozawa S,Evans DR,Higgins CR,Laing SK,Awor P

更新日期：2019-01-09 00:00:00

abstract：BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...

journal_title：Malaria journal

authors： Portugal-Calisto D,Ferreira AR,Silva MS,Teodósio R

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...

journal_title：Malaria journal

authors： Kibret S,Lautze J,McCartney M,Nhamo L,Wilson GG

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Malaria is highly prevalent in many parts of India and is mostly caused by the parasite species Plasmodium vivax followed by Plasmodium falciparum. Chloroquine (CQ) is the first-line treatment for blood stage P. vivax parasites, but cases of drug resistance to CQ have been reported from India. One of the sur...

journal_title：Malaria journal

authors： Joy S,Mukhi B,Ghosh SK,Achur RN,Gowda DC,Surolia N

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify urinary biomarkers of falciparum malaria. METHODS:The study used a ca...

journal_title：Malaria journal

authors： Abdelrazig S,Ortori CA,Davey G,Deressa W,Mulleta D,Barrett DA,Amberbir A,Fogarty AW

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...

journal_title：Malaria journal

authors： Noone C,Parkinson M,Dowling DJ,Aldridge A,Kirwan P,Molloy SF,Asaolu SO,Holland C,O'Neill SM

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Thrombocytopaenia is the most frequent malaria-associated haematologic alteration observed with all five Plasmodium parasites causing disease in humans. Although not included in the World Health Organization criteria for severe Plasmodium falciparum malaria, severe thrombocytopaenia has been increasingly men...

journal_title：Malaria journal

authors： Antinori S,Corona A,Ridolfo AL,Galimberti L,Ricaboni D,Milazzo L,Corbellino M

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Plasmodium infections trigger complex immune reactions from their hosts against several life stages of the parasite, including gametocytes. These immune responses are highly variable, depending on age, genetics, and exposure history of the host as well as species and strain of parasite. Although the effects ...

journal_title：Malaria journal

authors： McQueen PG,Williamson KC,McKenzie FE

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d'Ivoire, where palm oil plantations remain the predominant agricultural crop, the susceptibility of wild Anopheles...

journal_title：Malaria journal

authors： Sadia-Kacou CMA,Alou LPA,Edi AVC,Yobo CM,Adja MA,Ouattara AF,Malone D,Koffi AA,Tano Y,Koudou BG

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour have revealed that local illness concepts linked to convulsions (referred to as degedege in Tanzanian Kiswahili) calle...

journal_title：Malaria journal

authors： Dillip A,Hetzel MW,Gosoniu D,Kessy F,Lengeler C,Mayumana I,Mshana C,Mshinda H,Schulze A,Makemba A,Pfeiffer C,Weiss MG,Obrist B

更新日期：2009-06-29 00:00:00

abstract：BACKGROUND:Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is cor...

journal_title：Malaria journal

authors： Dhabangi A,Mworozi E,Lubega IR,Cserti-Gazdewich CM,Maganda A,Dzik WH

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for malaria provide a practical alternative to light microscopy for malaria diagnosis in resource-limited settings. Three-band RDTs incorporating two parasite antigens may have enhanced diagnostic specificity, relative to two-band RDTs with a single parasite antigen (typically h...

journal_title：Malaria journal

authors： Hawkes M,Conroy AL,Opoka RO,Namasopo S,Liles WC,John CC,Kain KC

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria, but may probably also worsen the severity of imported cases. The ...

journal_title：Malaria journal

authors： Vliegenthart-Jongbloed K,de Mendonça Melo M,van Wolfswinkel ME,Koelewijn R,van Hellemond JJ,van Genderen PJ

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Defining the number and location of sprayable structures (houses) is foundational to plan and monitor indoor residual spray (IRS) implementation, a primary intervention used to control the transmission of malaria. Only by mapping the location and type of all sprayable structures can IRS operations be planned...

journal_title：Malaria journal

authors： Kamanga A,Renn S,Pollard D,Bridges DJ,Chirwa B,Pinchoff J,Larsen DA,Winters AM

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...

journal_title：Malaria journal

authors： Li Z,Zhang Q,Zheng C,Zhou S,Sun J,Zhang Z,Geng Q,Zhang H,Wang L,Lai S,Hu W,Clements AC,Zhou XN,Yang W

更新日期：2016-03-05 00:00:00

abstract：BACKGROUND:In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). METHODS:In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH...

journal_title：Malaria journal

authors： Ashley EA,Touabi M,Ahrer M,Hutagalung R,Htun K,Luchavez J,Dureza C,Proux S,Leimanis M,Lwin MM,Koscalova A,Comte E,Hamade P,Page AL,Nosten F,Guerin PJ

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for th...

journal_title：Malaria journal

authors： Briand V,Cottrell G,Tuike Ndam N,Martiáñez-Vendrell X,Vianou B,Mama A,Kouwaye B,Houzé S,Bailly J,Gbaguidi E,Sossou D,Massougbodji A,Accrombessi M,Mayor A,Ding XC,Fievet N

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich prot...

journal_title：Malaria journal

authors： Nyunt MH,Kyaw MP,Win KK,Myint KM,Nyunt KM

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...

journal_title：Malaria journal

authors： Verma G,Surolia N

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women i...

journal_title：Malaria journal

authors： Mosha D,Mazuguni F,Mrema S,Sevene E,Abdulla S,Genton B

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...

journal_title：Malaria journal

authors： Valencia SH,Ocampo ID,Arce-Plata MI,Recht J,Arévalo-Herrera M

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...

journal_title：Malaria journal

authors： Kang S,Jung J,Lee S,Hwang H,Kim W

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...

journal_title：Malaria journal

authors： Zikusooka CM,McIntyre D,Barnes KI

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epidemiological survey was conducted in September-October 2012, as a baseline underlying a 3-year popu...

journal_title：Malaria journal

authors： Rosas-Aguirre A,Guzman-Guzman M,Gamboa D,Chuquiyauri R,Ramirez R,Manrique P,Carrasco-Escobar G,Puemape C,Llanos-Cuentas A,Vinetz JM

更新日期：2017-08-04 00:00:00

abstract：:The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and...

journal_title：Malaria journal

authors： Thriemer K,Bobogare A,Ley B,Gudo CS,Alam MS,Anstey NM,Ashley E,Baird JK,Gryseels C,Jambert E,Lacerda M,Laihad F,Marfurt J,Pasaribu AP,Poespoprodjo JR,Sutanto I,Taylor WR,van den Boogaard C,Battle KE,Dysoley L,Ghim

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:The current status of insecticide resistance and the underlying resistance mechanisms were studied in the major vector of malaria, Anopheles culicifacies, and the secondary vector, Anopheles subpictus in five districts (Anuradhapura, Kurunegala, Moneragala, Puttalam and Trincomalee) of Sri Lanka. Eight other...

journal_title：Malaria journal

authors： Perera MD,Hemingway J,Karunaratne SP

更新日期：2008-08-28 00:00:00