Abstract:
BACKGROUND:While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women. METHODS:This was a retrospective study based on samples collected in Benin from 2014 to 2017. A total of 942 whole blood samples collected in 327 women in the 1st and 3rd trimesters and at delivery were tested by uRDT, conventional RDT (cRDT, SD BIOLINE Malaria Ag Pf), microscopy, quantitative polymerase chain-reaction (qPCR) and Luminex-based suspension array technology targeting P. falciparum HRP2. The performance of each RDT was evaluated using qPCR as reference standard. The association between infections detected by uRDT, but not by cRDT, with poor maternal and birth outcomes was assessed using multivariate regression models. RESULTS:The overall positivity rate detected by cRDT, uRDT, and qPCR was 11.6% (109/942), 16.2% (153/942) and 18.3% (172/942), respectively. Out of 172 qPCR-positive samples, 68 were uRDT-negative. uRDT had a significantly better sensitivity (60.5% [52.7-67.8]) than cRDT (44.2% [36.6-51.9]) and a marginally decreased specificity (93.6% [91.7-95.3] versus 95.7% [94.0-97.0]). The gain in sensitivity was particularly high (33%) and statistically significant in the 1st trimester. Only 28 (41%) out of the 68 samples which were qPCR-positive, but uRDT-negative had detectable but very low levels of HRP2 (191 ng/mL). Infections that were detected by uRDT but not by cRDT were associated with a 3.4-times (95%CI 1.29-9.19) increased risk of anaemia during pregnancy. CONCLUSIONS:This study demonstrates the higher performance of uRDT, as compared to cRDTs, to detect low parasite density P. falciparum infections during pregnancy, particularly in the 1st trimester. uRDT allowed the detection of infections associated with maternal anaemia.
journal_name
Malar Jjournal_title
Malaria journalauthors
Briand V,Cottrell G,Tuike Ndam N,Martiáñez-Vendrell X,Vianou B,Mama A,Kouwaye B,Houzé S,Bailly J,Gbaguidi E,Sossou D,Massougbodji A,Accrombessi M,Mayor A,Ding XC,Fievet Ndoi
10.1186/s12936-020-03261-1subject
Has Abstractpub_date
2020-05-24 00:00:00pages
188issue
1issn
1475-2875pii
10.1186/s12936-020-03261-1journal_volume
19pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:There is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets (LLINs). Combination LLINs are designed to control susceptible and pyrethroid-resistant mosquito populations through a mixture of pyrethroid with piperonyl butoxid...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-017-2124-1
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-327
更新日期:2012-09-13 00:00:00
abstract:BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2186-8
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) are assumed to be simple-to-use and mobile technologies that have the capacity to standardize parasitological diagnosis for malaria across a variety of clinical settings. In order to evaluate these tests, it is important to consider how such assumptions play out in pract...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1083-2
更新日期:2016-02-05 00:00:00
abstract::Genetic manipulation of malaria parasites remains an inefficient, time-consuming and resource-intensive process. Presented here is a set of methods for 96-well plate-based transfection and culture that improve the efficiency of genetic manipulation of Plasmodium falciparum. Compared to standard protocols plate-based t...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-22
更新日期:2012-01-18 00:00:00
abstract:BACKGROUND:Malaria is seasonal and this may influence the number of children being treated as outpatients in hospitals. The objective of this study was to investigate the degree of seasonality in malaria in lakeshore and highland areas of Zomba district Malawi, and influence of climatic factors on incidence of malaria....
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1913-x
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:Combination treatments, preferably containing an artemisinin derivative, are recommended to improve efficacy and prevent Plasmodium falciparum drug resistance. Artemether-lumefantrine (AL) and artesunate-amodiaquine (AA) are efficacious regimens that have been widely adopted in sub-Saharan Africa. However, m...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-9-335
更新日期:2010-11-22 00:00:00
abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-12-399
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:Within the context of combined interventions, malaria vaccine may provide additional value in malaria prevention. Stakeholders' perspectives are thus critical for informed recommendation of the vaccine in Tanzania. This paper presents the views of stakeholders with regards to malaria vaccine in 12 Tanzanian ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1209-6
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. However, people with glucose-6-phosphate dehydrogenase (G...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2715-0
更新日期:2019-03-12 00:00:00
abstract::The Global Technical Strategy 2016-2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria transmission, the reservoir of human infection may be intermittently symptomatic or fully silent yet still lea...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2906-8
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Current available malaria diagnostic methods each have some limitations to meet the need for real-time and large-scale screening of asymptomatic and low density malaria infection at community level. It was proposed that malaria parasite-specific low molecular-weight metabolites could be used as biomarkers fo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0651-1
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Malaria remains a major public health problem, and its control has been hampered by drug resistance. For a number of drugs, Plasmodium falciparum single nucleotide polymorphisms (SNPs) are associated with altered drug sensitivity and can be used as markers of drug resistance. Several techniques have been stu...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-95
更新日期:2014-03-14 00:00:00
abstract::BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-1
更新日期:2004-01-29 00:00:00
abstract:BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2087-2
更新日期:2017-10-30 00:00:00
abstract:BACKGROUND:A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes reflect intraerythrocytic removal of malarial parasites with a concurrent removal of RBC membrane through...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-64
更新日期:2006-07-31 00:00:00
abstract:BACKGROUND:Over the past several years, thousands of microRNAs (miRNAs) have been identified in the genomes of various insects through cloning and sequencing or even by computational prediction. However, the number of miRNAs identified in anopheline species is low and little is known about their role. The mosquito Anop...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1591-0
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R and G353V) were rece...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03281-x
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1317-3
更新日期:2016-05-06 00:00:00
abstract:BACKGROUND:Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measur...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1795-y
更新日期:2017-04-14 00:00:00
abstract::In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-017-1891-z
更新日期:2017-06-09 00:00:00
abstract:BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-151
更新日期:2012-05-03 00:00:00
abstract:BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-228
更新日期:2010-08-09 00:00:00
abstract:BACKGROUND:The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early le...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-150
更新日期:2011-06-06 00:00:00
abstract:BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2642-0
更新日期:2019-01-14 00:00:00
abstract::Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens. These challenges are illustrated by using a mathematical model to describe the association between the pr...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-280
更新日期:2013-08-08 00:00:00
abstract:BACKGROUND:Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-109
更新日期:2010-04-23 00:00:00
abstract:BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-273
更新日期:2010-10-08 00:00:00
abstract:BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2226-4
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Malaria in Southeast Asia frequently clusters along international borders. For example, while most of Thailand is malaria free, the border region shared with Myanmar continues to have endemic malaria. This spatial pattern is the result of complex interactions between landscape, humans, mosquito vectors, and ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0921-y
更新日期:2015-10-05 00:00:00