Synergism from combinations of infection-blocking malaria vaccines.

abstract：BACKGROUND:Avian malaria vector competence studies are needed to understand more succinctly complex avian parasite-vector-relations. The lack of vector competence trials may be attributed to the difficulty of obtaining gametocytes for the majority of Plasmodium species and lineages. To conduct avian malaria infectivity...

journal_title：Malaria journal

authors： Carlson JS,Giannitti F,Valkiūnas G,Tell LA,Snipes J,Wright S,Cornel AJ

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...

journal_title：Malaria journal

authors： Na-Bangchang K,Ruengweerayut R,Mahamad P,Ruengweerayut K,Chaijaroenkul W

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have s...

journal_title：Malaria journal

authors： Hanemaaijer MJ,Higgins H,Eralp I,Yamasaki Y,Becker N,Kirstein OD,Lanzaro GC,Lee Y

更新日期：2019-04-11 00:00:00

abstract：:The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facility records to evaluate the impact of malaria control efforts in Rwanda and Ethiopia. Although the authors dem...

journal_title：Malaria journal

authors： Rowe AK,Kachur SP,Yoon SS,Lynch M,Slutsker L,Steketee RW

更新日期：2009-09-03 00:00:00

abstract：BACKGROUND:Universal coverage with long-lasting insecticidal mosquito nets (LLIN) or indoor residual spraying (IRS) of houses remain the primary strategies for the control of mosquito vectors of malaria. Pyrethroid resistant malaria vectors are widespread throughout sub-Saharan Africa and new insecticides with differen...

journal_title：Malaria journal

authors： Oxborough RM,N'Guessan R,Kitau J,Tungu PK,Malone D,Mosha FW,Rowland MW

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...

journal_title：Malaria journal

authors： Animut A,Negash Y,Kebede N

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...

journal_title：Malaria journal

authors： Lusingu JP,Vestergaard LS,Mmbando BP,Drakeley CJ,Jones C,Akida J,Savaeli ZX,Kitua AY,Lemnge MM,Theander TG

更新日期：2004-07-28 00:00:00

abstract：BACKGROUND:Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children. METHODS:The factors contributing to delay in parasite clearance, def...

journal_title：Malaria journal

authors： Sowunmi A,Adewoye EO,Gbotsho GO,Happi CT,Sijuade A,Folarin OA,Okuboyejo TM,Michael OS

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:Resistance of Plasmodium falciparum to anti-malarial drugs has hampered efforts to eradicate malaria. Recent reports of a decline in the prevalence of chloroquine-resistant P. falciparum in several countries, including Malawi and Zambia, is raising the hope of reintroducing chloroquine in the near future, id...

journal_title：Malaria journal

authors： Dagnogo O,Ako AB,Ouattara L,Dago ND,Coulibaly DN,Touré AO,Djaman JA

更新日期：2018-11-07 00:00:00

abstract：:April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness, to review progress and renew commitments. After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in...

journal_title：Malaria journal

authors： Slutsker L,Kachur SP

更新日期：2013-04-24 00:00:00

abstract：BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...

journal_title：Malaria journal

authors： Kattenberg JH,Erhart A,Truong MH,Rovira-Vallbona E,Vu KAD,Nguyen THN,Nguyen VH,Nguyen VV,Bannister-Tyrrell M,Theisen M,Bennet A,Lover AA,Tran TD,Nguyen XX,Rosanas-Urgell A

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the profile of antibodies against several antigens of Plasmodium vivax and Plasmodium falciparum in Mandalay, Myanmar. METHODS:Malaria parasites were identified by microscopic examination. To test the antibodies against P. vivax and P. falciparum in sera, an indirect...

journal_title：Malaria journal

authors： Kim TS,Kim HH,Kim JY,Kong Y,Na BK,Lin K,Moon SU,Kim YJ,Kwon MH,Sohn Y,Kim H,Lee HW

更新日期：2011-08-06 00:00:00

abstract：BACKGROUND:Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epidemiological survey was conducted in September-October 2012, as a baseline underlying a 3-year popu...

journal_title：Malaria journal

authors： Rosas-Aguirre A,Guzman-Guzman M,Gamboa D,Chuquiyauri R,Ramirez R,Manrique P,Carrasco-Escobar G,Puemape C,Llanos-Cuentas A,Vinetz JM

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, the drug resistance profile of current and previous first-line anti-malarials in Kenya was assessed w...

journal_title：Malaria journal

authors： Shah M,Omosun Y,Lal A,Odero C,Gatei W,Otieno K,Gimnig JE,ter Kuile F,Hawley WA,Nahlen B,Kariuki S,Walker E,Slutsker L,Hamel M,Shi YP

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Plasmodium infections trigger complex immune reactions from their hosts against several life stages of the parasite, including gametocytes. These immune responses are highly variable, depending on age, genetics, and exposure history of the host as well as species and strain of parasite. Although the effects ...

journal_title：Malaria journal

authors： McQueen PG,Williamson KC,McKenzie FE

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...

journal_title：Malaria journal

authors： Junior SG,Pamplona VM,Corvelo TC,Ramos EM

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

journal_title：Malaria journal

authors： Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

journal_title：Malaria journal

authors： Obbard DJ,Welch JJ,Little TJ

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:The recent reports on the decreasing susceptibility of Plasmodium falciparum to artemisinin derivatives along the Thailand and Myanmar border are worrying. Indeed it may spread to India and then Africa, repeating the same pattern observed for chloroquine resistance. Therefore, it is essential to start monito...

journal_title：Malaria journal

authors： Tinto H,Bonkian LN,Nana LA,Yerbanga I,Lingani M,Kazienga A,Valéa I,Sorgho H,Kpoda H,Guiguemdé TR,Ouédraogo JB,Mens PF,Schallig H,D'Alessandro U

更新日期：2014-05-31 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...

journal_title：Malaria journal

authors： Srisutham S,Suwannasin K,Mathema VB,Sriprawat K,Smithuis FM,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Iba...

journal_title：Malaria journal

authors： Falade CO,Yusuf BO,Fadero FF,Mokuolu OA,Hamer DH,Salako LA

更新日期：2007-07-06 00:00:00

abstract：BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...

journal_title：Malaria journal

authors： Fouque F,Gaborit P,Carinci R,Issaly J,Girod R

更新日期：2010-03-22 00:00:00

abstract：BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...

journal_title：Malaria journal

authors： Grossenbacher B,Holzschuh A,Hofmann NE,Omar KA,Stuck L,Fakih BS,Ali A,Yukich J,Hetzel MW,Felger I

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Determination of the genetic diversity of malaria parasites can inform the intensity of transmission and identify potential deficiencies in malaria control programmes. This study was conducted to characterize the genetic diversity and allele frequencies of Plasmodium falciparum in Northwest Ethiopia along th...

journal_title：Malaria journal

authors： Mohammed H,Kassa M,Mekete K,Assefa A,Taye G,Commons RJ

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of mal...

journal_title：Malaria journal

authors： Ademolue TW,Aniweh Y,Kusi KA,Awandare GA

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

journal_title：Malaria journal

authors： Baton LA,Ranford-Cartwright LC

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

journal_title：Malaria journal

authors： Fu Y,Ding Y,Zhou T,Fu X,Xu W

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition...

journal_title：Malaria journal

authors： Zhao X,Chen F,Feng Z,Li X,Zhou XH

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physicall...

journal_title：Malaria journal

authors： Briet O,Koenker H,Norris L,Wiegand R,Vanden Eng J,Thackeray A,Williamson J,Gimnig JE,Fortes F,Akogbeto M,Yadouleton AW,Ombok M,Bayoh MN,Mzilahowa T,Abílio AP,Mabunda S,Cuamba N,Diouf E,Konaté L,Hamainza B,Katebe-S

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:The sulphadoxine/pyrimethamine (SDX/PYR) combination had been chosen to treat uncomplicated falciparum malaria in Malaysia for more than 30 years. Non-silent mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes are responsible for the resistance to pyrimethamine and sulphadox...

journal_title：Malaria journal

authors： Lau TY,Sylvi M,William T

更新日期：2013-12-10 00:00:00