Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.

abstract：:Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather th...

journal_title：Malaria journal

authors： Hastings IM,Hodel EM

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...

journal_title：Malaria journal

authors： Ezenduka CC,Ogbonna BO,Ekwunife OI,Okonta MJ,Esimone CO

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:Malaria is one of the most severe public health issues that result in massive morbidity and mortality in most countries of the sub-Saharan Africa (SSA). This study aimed to determine the scope of household, accessibility to malaria care and factors associated with household malaria in the Democratic Republic...

journal_title：Malaria journal

authors： Ngatu NR,Kanbara S,Renzaho A,Wumba R,Mbelambela EP,Muchanga SMJ,Muzembo BA,Leon-Kabamba N,Nattadech C,Suzuki T,Oscar-Luboya N,Wada K,Ikeda M,Nojima S,Sugishita T,Ikeda S

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...

journal_title：Malaria journal

authors： Junior SG,Pamplona VM,Corvelo TC,Ramos EM

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:Donor financing for malaria has declined since 2010 and this trend is projected to continue for the foreseeable future. These reductions have a significant impact on lower burden countries actively pursuing elimination, which are usually a lesser priority for donors. While domestic spending on malaria has be...

journal_title：Malaria journal

authors： Shretta R,Zelman B,Birger ML,Haakenstad A,Singh L,Liu Y,Dieleman J

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:The use of insecticide-treated nets (ITN) is an important tool in the Roll Back Malaria (RBM) strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and u...

journal_title：Malaria journal

authors： Toé LP,Skovmand O,Dabiré KR,Diabaté A,Diallo Y,Guiguemdé TR,Doannio JM,Akogbeto M,Baldet T,Gruénais ME

更新日期：2009-07-29 00:00:00

abstract：BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...

journal_title：Malaria journal

authors： van Schalkwyk DA,Burrow R,Henriques G,Gadalla NB,Beshir KB,Hasford C,Wright SG,Ding XC,Chiodini PL,Sutherland CJ

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become an essential tool in the contemporary malaria control and management programmes in the world. This study aims to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area. METHODS:A total 606 febrile patients in the Ch...

journal_title：Malaria journal

authors： Yan J,Li N,Wei X,Li P,Zhao Z,Wang L,Li S,Li X,Wang Y,Li S,Yang Z,Zheng B,Zhou G,Yan G,Cui L,Cao Y,Fan Q

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:Challenges persist in ensuring access to and optimal use of long-lasting, insecticidal bed nets (LLINs). Factors associated with ownership and use may differ depending on the history of malaria and prevention control efforts in a specific region. Understanding how the cultural and social-environmental contex...

journal_title：Malaria journal

authors： Ernst KC,Hayden MH,Olsen H,Cavanaugh JL,Ruberto I,Agawo M,Munga S

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...

journal_title：Malaria journal

authors： Fortpied J,Collignon S,Moniotte N,Renaud F,Bayat B,Lemoine D

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...

journal_title：Malaria journal

authors： Dinzouna-Boutamba SD,Yang HW,Joo SY,Jeong S,Na BK,Inoue N,Lee WK,Kong HH,Chung DI,Goo YK,Hong Y

更新日期：2014-06-30 00:00:00

abstract：BACKGROUND:Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors and malaria prevalence in Indonesia. METHODS:The study used a cross-sectional design and analysed re...

journal_title：Malaria journal

authors： Hasyim H,Dale P,Groneberg DA,Kuch U,Müller R

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Malaria is highly prevalent in many parts of India and is mostly caused by the parasite species Plasmodium vivax followed by Plasmodium falciparum. Chloroquine (CQ) is the first-line treatment for blood stage P. vivax parasites, but cases of drug resistance to CQ have been reported from India. One of the sur...

journal_title：Malaria journal

authors： Joy S,Mukhi B,Ghosh SK,Achur RN,Gowda DC,Surolia N

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...

journal_title：Malaria journal

authors： Gomez-Elipe A,Otero A,van Herp M,Aguirre-Jaime A

更新日期：2007-09-24 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

journal_title：Malaria journal

authors： Fu Y,Ding Y,Zhou T,Fu X,Xu W

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...

journal_title：Malaria journal

authors： Li Z,Zhang Q,Zheng C,Zhou S,Sun J,Zhang Z,Geng Q,Zhang H,Wang L,Lai S,Hu W,Clements AC,Zhou XN,Yang W

更新日期：2016-03-05 00:00:00

abstract：BACKGROUND:The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). METHODS:This study was a series of qualit...

journal_title：Malaria journal

authors： Kaufman MR,Rweyemamu D,Koenker H,Macha J

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...

journal_title：Malaria journal

authors： Ba H,Duffy CW,Ahouidi AD,Deh YB,Diallo MY,Tandia A,Conway DJ

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of...

journal_title：Malaria journal

authors： Ntamabyaliro NY,Burri C,Nzolo DB,Engo AB,Lula YN,Mampunza SM,Nsibu CN,Mesia GK,Kayembe JN,Likwela JL,Kintaudi LM,Tona GL

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...

journal_title：Malaria journal

authors： Kang S,Jung J,Lee S,Hwang H,Kim W

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...

journal_title：Malaria journal

authors： Mutanda AL,Cheruiyot P,Hodges JS,Ayodo G,Odero W,John CC

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected people in the area and to identify the factors influencing malaria transmission. METHODS:Demograph...

journal_title：Malaria journal

authors： Sérandour J,Girel J,Boyer S,Ravanel P,Lemperière G,Raveton M

更新日期：2007-08-29 00:00:00

abstract：BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...

journal_title：Malaria journal

authors： Zhu L,Marshall JM,Qualls WA,Schlein Y,McManus JW,Arheart KL,Hlaing WM,Traore SF,Doumbia S,Müller GC,Beier JC

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Malaria is a major health problem in sub-Saharan Africa where over 90% of the world's malaria cases occur. Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization as first-line and second-line treatments for uncomplicated falciparum malaria. However, there are a growing nu...

journal_title：Malaria journal

authors： Ndwigah S,Stergachis A,Abuga K,Mugo H,Kibwage I

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include outdoor biting, sub-optimal implementation and inappropriate use. New vector control interventions are required and ...

journal_title：Malaria journal

authors： Makungu C,Stephen S,Kumburu S,Govella NJ,Dongus S,Hildon ZJ,Killeen GF,Jones C

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...

journal_title：Malaria journal

authors： Buregyeya E,Rutebemberwa E,LaRussa P,Lal S,Clarke SE,Hansen KS,Magnussen P,Mbonye AK

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of T76 mutation in the pfcrt gene. This situation has several health implications, one being that mutations that confer resistance ...

journal_title：Malaria journal

authors： Asare KK,Boampong JN,Afoakwah R,Ameyaw EO,Sehgal R,Quashie NB

更新日期：2014-06-26 00:00:00

abstract：BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...

journal_title：Malaria journal

authors： Lusingu JP,Vestergaard LS,Mmbando BP,Drakeley CJ,Jones C,Akida J,Savaeli ZX,Kitua AY,Lemnge MM,Theander TG

更新日期：2004-07-28 00:00:00

abstract：:Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009-2011 and 2015-2016, Tanz...

journal_title：Malaria journal

authors： Yukich J,Stuck L,Scates S,Wisniewski J,Chacky F,Festo C,Kabulika G,Dimoso K,Mandike R,Greer G,Serbantez N,Elisaria E,Nyoni W,Dadi D,Akim I,Lengeler C,Brown N,Koenker H

更新日期：2020-04-17 00:00:00

abstract：BACKGROUND:Genetically-modified (GM) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. Public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (GMOs) face strong scepticism in d...

journal_title：Malaria journal

authors： Marshall JM,Touré MB,Traore MM,Famenini S,Taylor CE

更新日期：2010-05-14 00:00:00