The development of loop-mediated isothermal amplification targeting alpha-tubulin DNA for the rapid detection of Plasmodium vivax.

abstract：BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...

journal_title：Malaria journal

authors： Tougan T,Toya Y,Uchihashi K,Horii T

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Behaviour change communication (BCC) can improve malaria prevention and treatment behaviour. As a one of the activities under Myanmar Artemisinin Resistance Containment (MARC) programme, BCC have been conducting. This study aimed to evaluate the effectiveness of the behaviour change communication and communi...

journal_title：Malaria journal

authors： Nyunt MH,Aye KM,Kyaw MP,Wai KT,Oo T,Than A,Oo HW,Phway HP,Han SS,Htun T,San KK

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality ...

journal_title：Malaria journal

authors： Yasuoka J,Poudel KC,Poudel-Tandukar K,Nguon C,Ly P,Socheat D,Jimba M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and house modifications are proven vector control tools, yet in most regions, full coverage has not been achieved. This study investigates household factors associated with access to ITNs and house modification in Tanzania. METHODS:Baseline cross-sectional survey data from pr...

journal_title：Malaria journal

authors： Odufuwa OG,Ross A,Mlacha YP,Juma O,Mmbaga S,Msellemu D,Moore S

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...

journal_title：Malaria journal

authors： Bharti PK,Silawat N,Singh PP,Singh MP,Shukla M,Chand G,Dash AP,Singh N

更新日期：2008-07-11 00:00:00

abstract：:Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...

journal_title：Malaria journal

authors： Morris CA,Duparc S,Borghini-Fuhrer I,Jung D,Shin CS,Fleckenstein L

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:Malaria is one of the most severe global public health problems worldwide, particularly in Africa, where Nigeria has the greatest number of malaria cases. This community-based study was designed to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices ...

journal_title：Malaria journal

authors： Dawaki S,Al-Mekhlafi HM,Ithoi I,Ibrahim J,Atroosh WM,Abdulsalam AM,Sady H,Elyana FN,Adamu AU,Yelwa SI,Ahmed A,Al-Areeqi MA,Subramaniam LR,Nasr NA,Lau YL

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...

journal_title：Malaria journal

authors： Hombhanje FW,Linge D,Saweri A,Kuanch C,Jones R,Toraso S,Geita J,Masta A,Kevau I,Hiawalyer G,Sapuri M

更新日期：2009-08-12 00:00:00

abstract：BACKGROUND:Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China-Myanmar border to provide epidemio...

journal_title：Malaria journal

authors： Geng J,Malla P,Zhang J,Xu S,Li C,Zhao Y,Wang Q,Kyaw MP,Cao Y,Yang Z,Cui L

更新日期：2019-09-12 00:00:00

abstract：BACKGROUND:Anopheles baimaii is a primary vector of human malaria in the forest settings of Southeast Asia including the north-eastern region of India. Here, the genetic population structure and the basic population genetic parameters of An. baimaii in north-east India were estimated using DNA sequences of the mitochon...

journal_title：Malaria journal

authors： Sarma DK,Prakash A,O'Loughlin SM,Bhattacharyya DR,Mohapatra PK,Bhattacharjee K,Das K,Singh S,Sarma NP,Ahmed GU,Walton C,Mahanta J

更新日期：2012-03-20 00:00:00

abstract：BACKGROUND:In many low-income countries, the private commercial sector plays an important role in the provision of malaria treatment. However, the quality of care it provides is often poor, with artemisinin combination therapy (ACT) generally being too costly for consumers. Decreasing ACT prices is critical for improvi...

journal_title：Malaria journal

authors： Patouillard E,Hanson K,Kleinschmidt I,Palafox B,Tougher S,Pok S,O'Connell K,Goodman C

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...

journal_title：Malaria journal

authors： Kilian A,Boulay M,Koenker H,Lynch M

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the con...

journal_title：Malaria journal

authors： Nieto CA,Sánchez LM,Sánchez DM,Díaz GJ,Ramírez MH

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS:In February/March 2006, a survey was...

journal_title：Malaria journal

authors： Tipke M,Louis VR,Yé M,De Allegri M,Beiersmann C,Sié A,Mueller O,Jahn A

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH-based tests become negative more quickly, but sensitivity has been reported below the recommended standard of 90%. A new pLDH test, CareS...

journal_title：Malaria journal

authors： Gerstl S,Dunkley S,Mukhtar A,De Smet M,Baker S,Maikere J

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs s...

journal_title：Malaria journal

authors： Mugasa J,Qi W,Rusch S,Rottmann M,Beck HP

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Unde...

journal_title：Malaria journal

authors： Amegashie EA,Amenga-Etego L,Adobor C,Ogoti P,Mbogo K,Amambua-Ngwa A,Ghansah A

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. METHODS:This study was ...

journal_title：Malaria journal

authors： Yentur Doni N,Yildiz Zeyrek F,Seyrek A

更新日期：2016-05-28 00:00:00

abstract：BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...

journal_title：Malaria journal

authors： Okello G,Ndegwa SN,Halliday KE,Hanson K,Brooker SJ,Jones C

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...

journal_title：Malaria journal

authors： Okell LC,Paintain LS,Webster J,Hanson K,Lines J

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Cerebral malaria (CM) is associated with morbidity and mortality despite the use of potent anti-malarial agents. Brain endothelial cell activation and dysfunction from oxidative and inflammatory host responses and products released by Plasmodium falciparum-infected erythrocytes (IE), are likely the major con...

journal_title：Malaria journal

authors： Mita-Mendoza NK,Magallon-Tejada A,Parmar P,Furtado R,Aldrich M,Saidi A,Taylor T,Smith J,Seydel K,Daily JP

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Current available malaria diagnostic methods each have some limitations to meet the need for real-time and large-scale screening of asymptomatic and low density malaria infection at community level. It was proposed that malaria parasite-specific low molecular-weight metabolites could be used as biomarkers fo...

journal_title：Malaria journal

authors： Park YH,Shi YP,Liang B,Medriano CA,Jeon YH,Torres E,Uppal K,Slutsker L,Jones DP

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...

journal_title：Malaria journal

authors： Shaukat AM,Breman JG,McKenzie FE

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:Malaria is a global health emergency, and yet our understanding of the energy metabolism of the principle causative agent of this devastating disease, Plasmodium falciparum, remains rather basic. Glucose was shown to be an essential nutritional requirement nearly 100 years ago and since this original observa...

journal_title：Malaria journal

authors： Lian LY,Al-Helal M,Roslaini AM,Fisher N,Bray PG,Ward SA,Biagini GA

更新日期：2009-03-06 00:00:00

abstract：BACKGROUND:A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. METHODS:An increm...

journal_title：Malaria journal

authors： Moore BR,Davis WA,Clarke PM,Robinson LJ,Laman M,Davis TME

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...

journal_title：Malaria journal

authors： Mora-Ruiz M,Penilla RP,Ordóñez JG,López AD,Solis F,Torres-Estrada JL,Rodríguez AD

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested...

journal_title：Malaria journal

authors： Gosi P,Khusmith S,Khalambaheti T,Lanar DE,Schaecher KE,Fukuda MM,Miller SR

更新日期：2008-06-26 00:00:00