Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka.

abstract：BACKGROUND:Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and radio devices. Fluorescent dust is the most commonly used method to distinguish released individuals f...

journal_title：Malaria journal

authors： Aviles EI,Rotenberry RD,Collins CM,Dotson EM,Benedict MQ

更新日期：2020-07-06 00:00:00

abstract：:This article reports the changing pattern of US President's Malaria Initiative-funded IRS in sub-Saharan Africa between 2008 and 2015. IRS coverage in sub-Saharan Africa increased from <2 % of the at-risk population in 2005, to 11 % or 78 million people in 2010, mainly as a result of increased funding from PMI. The sc...

journal_title：Malaria journal

authors： Oxborough RM

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:Mutations in the haemoglobin beta-globin (HbB) and glucose-6-phosphate dehydrogenase (G6PD) genes cause widespread human genetic disorders such as sickle cell diseases and G6PD deficiency. In sub-Saharan Africa, a few predominant polymorphic variants of each gene account for a majority of these deficiencies....

journal_title：Malaria journal

authors： Enevold A,Vestergaard LS,Lusingu J,Drakeley CJ,Lemnge MM,Theander TG,Bygbjerg IC,Alifrangis M

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...

journal_title：Malaria journal

authors： Kattenberg JH,Erhart A,Truong MH,Rovira-Vallbona E,Vu KAD,Nguyen THN,Nguyen VH,Nguyen VV,Bannister-Tyrrell M,Theisen M,Bennet A,Lover AA,Tran TD,Nguyen XX,Rosanas-Urgell A

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS:Using a rodent malaria model system...

journal_title：Malaria journal

authors： Ferguson HM,Read AF

更新日期：2004-05-19 00:00:00

abstract：BACKGROUND:Drug resistance determination for Plasmodium falciparum infections are important to determining the type of treatment to be given. Besides in vivo experiments, molecular methods, such as sequencing and PCR, are now increasingly being used. Here a cheaper alternative to sequencing or the use of multiplex 5'nu...

journal_title：Malaria journal

authors： Gan LS,Loh JP

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Mal...

journal_title：Malaria journal

authors： Lima RB,Rocha e Silva LF,Melo MR,Costa JS,Picanço NS,Lima ES,Vasconcellos MC,Boleti AP,Santos JM,Amorim RC,Chaves FC,Coutinho JP,Tadei WP,Krettli AU,Pohlit AM

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:The zoonotic malaria parasite Plasmodium knowlesi has become an emerging threat to South East Asian countries particular in Malaysia. A recent study from Sarawak (Malaysian Borneo) discovered two distinct normocyte binding protein xa (Pknbpxa) types of P. knowlesi. In the present study, the Pknbpxa of clinic...

journal_title：Malaria journal

authors： Ahmed MA,Fong MY,Lau YL,Yusof R

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). METHODS:In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH...

journal_title：Malaria journal

authors： Ashley EA,Touabi M,Ahrer M,Hutagalung R,Htun K,Luchavez J,Dureza C,Proux S,Leimanis M,Lwin MM,Koscalova A,Comte E,Hamade P,Page AL,Nosten F,Guerin PJ

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:The effectiveness of vector control on malaria transmission by long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) depends on the vectors entering houses to blood feed and rest when people are inside houses. In the Solomon Islands, significant reductions in malaria have been achieved in...

journal_title：Malaria journal

authors： Russell TL,Beebe NW,Bugoro H,Apairamo A,Chow WK,Cooper RD,Collins FH,Lobo NF,Burkot TR

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eli...

journal_title：Malaria journal

authors： Song J,Socheat D,Tan B,Dara P,Deng C,Sokunthea S,Seila S,Ou F,Jian H,Li G

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...

journal_title：Malaria journal

authors： van Lenthe M,van der Meulen R,Lassovski M,Ouabo A,Bakula E,Badio C,Cibenda D,Okell L,Piriou E,Grignard L,Lanke K,Rao B,Bousema T,Roper C

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:Rosette-formation of Plasmodium falciparum parasitized erythrocytes is of importance in the development of severe malaria. The parasite-derived molecule PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1), central to rosetting, is suggested to be included in a multimeric vaccine targeting severe di...

journal_title：Malaria journal

authors： Angeletti D,Albrecht L,Wahlgren M,Moll K

更新日期：2013-01-24 00:00:00

abstract：BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...

journal_title：Malaria journal

authors： Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué F

更新日期：2012-03-16 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich prot...

journal_title：Malaria journal

authors： Nyunt MH,Kyaw MP,Win KK,Myint KM,Nyunt KM

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine. In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids. ME...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Bruce J,Jones C,Webster J,Snow RW

更新日期：2010-09-18 00:00:00

abstract：BACKGROUND:Drug combination therapy is the frontline of malaria treatment. There is an ever-accelerating need for new, efficacious combination therapies active against drug resistant malaria. Proven drugs already in the treatment pipeline, such as the quinolines, are important components of current combination therapy ...

journal_title：Malaria journal

authors： Gorka AP,Jacobs LM,Roepe PD

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...

journal_title：Malaria journal

authors： Sylla M,Kobylinski KC,Gray M,Chapman PL,Sarr MD,Rasgon JL,Foy BD

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:The widespread use of indoor-based malaria vector control interventions has been shown to alter the behaviour of vectors in Africa. There is an increasing concern that such changes could sustain residual transmission. This study was conducted to assess vector species composition, feeding behaviour and their ...

journal_title：Malaria journal

authors： Degefa T,Yewhalaw D,Zhou G,Lee MC,Atieli H,Githeko AK,Yan G

更新日期：2017-11-06 00:00:00

abstract：:The Rethinking Malaria Leadership Forum, held at Harvard Business School in February 2017 with collaboration of the Barcelona Institute for Global Health and the Swiss Tropical and Public Health Institute, identified this training gap as a high priority for both analysis and action. The gap in human resource training ...

journal_title：Malaria journal

authors： Wirth DF,Casamitjana N,Tanner M,Reich MR

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...

journal_title：Malaria journal

authors： Sharrock WW,Suwanarusk R,Lek-Uthai U,Edstein MD,Kosaisavee V,Travers T,Jaidee A,Sriprawat K,Price RN,Nosten F,Russell B

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. METHODS:This study was ...

journal_title：Malaria journal

authors： Yentur Doni N,Yildiz Zeyrek F,Seyrek A

更新日期：2016-05-28 00:00:00

abstract：BACKGROUND:While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for th...

journal_title：Malaria journal

authors： Briand V,Cottrell G,Tuike Ndam N,Martiáñez-Vendrell X,Vianou B,Mama A,Kouwaye B,Houzé S,Bailly J,Gbaguidi E,Sossou D,Massougbodji A,Accrombessi M,Mayor A,Ding XC,Fievet N

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...

journal_title：Malaria journal

authors： Ojakaa DI,Jarvis JD,Matilu MI,Thiam S

更新日期：2014-05-05 00:00:00

abstract：:The incidence and mortality of COVID-19, according to the World Health Organization reports, shows a noticeable difference between North America, Western Europe, and South Asia on one hand and most African countries on the other hand, especially the malaria-endemic countries. Although this observation could be attribu...

journal_title：Malaria journal

authors： Hussein MIH,Albashir AAD,Elawad OAMA,Homeida A

更新日期：2020-12-23 00:00:00

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：:The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

journal_title：Malaria journal

authors： Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

更新日期：2010-10-18 00:00:00

abstract：BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Goodman CA,Snow RW

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistanc...

journal_title：Malaria journal

authors： Dossou-Yovo LR,Ntoumi F,Koukouikila-Koussounda F,Vouvoungui JC,Adedoja A,Nderu D,Velavan TP,Lenga A

更新日期：2020-05-08 00:00:00