Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction.

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Long regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple locations across Southeast Asia. Gene...

journal_title：Malaria journal

authors： Ansbro MR,Jacob CG,Amato R,Kekre M,Amaratunga C,Sreng S,Suon S,Miotto O,Fairhurst RM,Wellems TE,Kwiatkowski DP

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Increased control has produced remarkable reductions of malaria in some parts of sub-Saharan Africa, including Rwanda. In the southern highlands, near the district capital of Butare (altitude, 1,768 m), a combined community-and facility-based survey on Plasmodium infection was conducted early in 2010. METHO...

journal_title：Malaria journal

authors： Gahutu JB,Steininger C,Shyirambere C,Zeile I,Cwinya-Ay N,Danquah I,Larsen CH,Eggelte TA,Uwimana A,Karema C,Musemakweri A,Harms G,Mockenhaupt FP

更新日期：2011-05-18 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Rapid diagnosis and correct treatment of cases are the main objectives of control programs in malaria-endemic areas. METHODS AND RESULTS:To evaluate these criteria and in a comparative study, blood specimens were collected from 120 volunteers seeking care at the Malaria Health Center in Chahbahar district. ...

journal_title：Malaria journal

authors： Zakeri S,Najafabadi ST,Zare A,Djadid ND

更新日期：2002-02-08 00:00:00

abstract：BACKGROUND:Drug and multidrug-resistant Plasmodium falciparum malaria has existed in Thailand for several decades. Furthermore, Thailand serves as a sentinel for drug-resistant malaria within the Greater Mekong sub-region. However, the drug resistance situation is highly dynamic, changing quickly over time. Here parasi...

journal_title：Malaria journal

authors： Parker D,Lerdprom R,Srisatjarak W,Yan G,Sattabongkot J,Wood J,Sirichaisinthop J,Cui L

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Measures of malaria burden using microscopy and rapid diagnostic tests (RDTs) in cross-sectional household surveys may incompletely describe the burden of malaria in low-transmission settings. This study describes the pattern of malaria transmission in Ethiopia using serological antibody estimates derived fr...

journal_title：Malaria journal

authors： Assefa A,Ali Ahmed A,Deressa W,Sime H,Mohammed H,Kebede A,Solomon H,Teka H,Gurrala K,Matei B,Wakeman B,Wilson GG,Sinha I,Maude RJ,Ashton R,Cook J,Shi YP,Drakeley C,von Seidlein L,Rogier E,Hwang J

更新日期：2019-07-22 00:00:00

abstract：BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...

journal_title：Malaria journal

authors： Kisinza WN,Nkya TE,Kabula B,Overgaard HJ,Massue DJ,Mageni Z,Greer G,Kaspar N,Mohamed M,Reithinger R,Moore S,Lorenz LM,Magesa S

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Monitoring and evaluation of malaria programmes may require a combination of approaches to detect any effects of control. This is particularly true at lower transmission levels where detecting both infection and exposure to infection will provide additional evidence of any change. This paper describes use of...

journal_title：Malaria journal

authors： Stevenson JC,Stresman GH,Baidjoe A,Okoth A,Oriango R,Owaga C,Marube E,Bousema T,Cox J,Drakeley C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. METHODS:Between December 2007 ...

journal_title：Malaria journal

authors： Damien GB,Djènontin A,Rogier C,Corbel V,Bangana SB,Chandre F,Akogbéto M,Kindé-Gazard D,Massougbodji A,Henry MC

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of mal...

journal_title：Malaria journal

authors： Ademolue TW,Aniweh Y,Kusi KA,Awandare GA

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs...

journal_title：Malaria journal

authors： Yewhalaw D,Kassahun W,Woldemichael K,Tushune K,Sudaker M,Kaba D,Duchateau L,Van Bortel W,Speybroeck N

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...

journal_title：Malaria journal

authors： Mora-Ruiz M,Penilla RP,Ordóñez JG,López AD,Solis F,Torres-Estrada JL,Rodríguez AD

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...

journal_title：Malaria journal

authors： Dev V,Sangma BM,Dash AP

更新日期：2010-09-22 00:00:00

abstract：BACKGROUND:Resistance of Plasmodium falciparum to anti-malarial drugs has hampered efforts to eradicate malaria. Recent reports of a decline in the prevalence of chloroquine-resistant P. falciparum in several countries, including Malawi and Zambia, is raising the hope of reintroducing chloroquine in the near future, id...

journal_title：Malaria journal

authors： Dagnogo O,Ako AB,Ouattara L,Dago ND,Coulibaly DN,Touré AO,Djaman JA

更新日期：2018-11-07 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors and malaria prevalence in Indonesia. METHODS:The study used a cross-sectional design and analysed re...

journal_title：Malaria journal

authors： Hasyim H,Dale P,Groneberg DA,Kuch U,Müller R

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For a...

journal_title：Malaria journal

authors： de Gier B,Suryapranata FS,Croughs M,van Genderen PJ,Keuter M,Visser LG,van Vugt M,Sonder GJ

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin wer...

journal_title：Malaria journal

authors： Antonio-Nkondjio C,Tene Fossog B,Kopya E,Poumachu Y,Menze Djantio B,Ndo C,Tchuinkam T,Awono-Ambene P,Wondji CS

更新日期：2015-04-14 00:00:00

abstract：:The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent primary research that addresses the putative relationship between agricultural insecticide use and trends in insecticide resistance. To do so, descriptive evidence o...

journal_title：Malaria journal

authors： Reid MC,McKenzie FE

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...

journal_title：Malaria journal

authors： Clements AC,Barnett AG,Cheng ZW,Snow RW,Zhou HN

更新日期：2009-07-31 00:00:00

abstract：BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...

journal_title：Malaria journal

authors： Weidner T,Lucantoni L,Nasereddin A,Preu L,Jones PG,Dzikowski R,Avery VM,Kunick C

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. ...

journal_title：Malaria journal

authors： Izri A,Cojean S,Leblanc C,Cohen Y,Bouchaud O,Durand R

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections. However methodological difficulties have impeded the use of nuclear markers such as m...

journal_title：Malaria journal

authors： Hellgren O,Kutzer M,Bensch S,Valkiūnas G,Palinauskas V

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:In Uganda, treatment of clinical malaria and intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) are common during pregnancy. As a result, both formal and informal reports from antenatal sources suggest possible misuse of SP for malaria treatment among pregnant women. The objective of this...

journal_title：Malaria journal

authors： Odongo CO,Bisaso KR,Kitutu F,Obua C,Byamugisha J

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:Mosquito larval control may prove to be an effective tool for incorporating into integrated vector management (IVM) strategies for reducing malaria transmission. Here the efficacy of microbial larvicides against Anopheles gambiae s.l. was tested in preparation for a large-scale larviciding programme in The G...

journal_title：Malaria journal

authors： Majambere S,Lindsay SW,Green C,Kandeh B,Fillinger U

更新日期：2007-06-07 00:00:00

abstract：BACKGROUND:Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify urinary biomarkers of falciparum malaria. METHODS:The study used a ca...

journal_title：Malaria journal

authors： Abdelrazig S,Ortori CA,Davey G,Deressa W,Mulleta D,Barrett DA,Amberbir A,Fogarty AW

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Very few data on anti-malarial efficacy are available from the Democratic Republic of Congo (DRC). DRC changed its anti-malarial treatment policy to amodiaquine (AQ) and artesunate (AS) in 2005. METHODS:The results of two in vivo efficacy studies, which tested AQ and sulphadoxine-pyrimethamine (SP) monother...

journal_title：Malaria journal

authors： Bonnet M,Broek Iv,van Herp M,Urrutia PP,van Overmeir C,Kyomuhendo J,Ndosimao CN,Ashley E,Guthmann JP

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...

journal_title：Malaria journal

authors： Beer N,Ali AS,de Savigny D,Al-Mafazy AW,Ramsan M,Abass AK,Omari RS,Björkman A,Källander K

更新日期：2010-06-18 00:00:00