Rapid evolution of pyrethroid resistance prevalence in Anopheles gambiae populations from the cities of Douala and Yaoundé (Cameroon).

Abstract:

BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin were carried out with two- to four-day old unfed Anopheles gambiae sensu lato adults raised from larvae collected from the field. Mosquitoes resistant to permethrin and deltamethrin and control were screened to detect the presence of the kdr alleles using the TaqMan assays. Mosquitoes belonging to the An. gambiae complex were subjected to PCR assays designed for species and molecular forms identifications. The genomic region containing the upstream of intron-1 of the voltage-gated sodium channel was sequenced and compared between mosquitoes originating from different breeding habitats. RESULTS:Anopheles gambiae s.l. specimens collected from the city of Douala were all Anopheles coluzzii. In Yaoundé, both An. gambiae and An. coluzzii were recorded. A rapid decrease of mosquito mortality to permethrin and deltamethrin was recorded between 2010 and 2013 in the two cities. The mortality rate varied from 80.3 to 22.3% and 94.4 to 59.7% for permethrin and deltamethrin, respectively. Both kdr alleles L1014F and L1014S were recorded. The frequency of kdr alleles increased rapidly over the study period, varying from 44 to 88.9% in Yaoundé and from 68 to 81% in Douala. The sequencing of a 1,228 bp region of intro-1 of the voltage-gated sodium channel revealed the presence of five different haplotypes. A high number of these haplotypes were recorded in An. coluzzii samples. No evidence for a recent selective sweep on intron-1 sequence within samples originating from different breeding habitat was detected using Fu's and Tajima Fs statistics. CONCLUSION:The present study supports rapid evolution of pyrethroid resistance in vector populations from the cities of Douala and Yaoundé and calls for immediate action to fight against the increasing prevalence of pyrethroid-resistant mosquitoes.

journal_name

Malar J

journal_title

Malaria journal

authors

Antonio-Nkondjio C,Tene Fossog B,Kopya E,Poumachu Y,Menze Djantio B,Ndo C,Tchuinkam T,Awono-Ambene P,Wondji CS

doi

10.1186/s12936-015-0675-6

subject

Has Abstract

pub_date

2015-04-14 00:00:00

pages

155

issn

1475-2875

pii

10.1186/s12936-015-0675-6

journal_volume

14

pub_type

杂志文章
  • Post-exposure serological responses to malaria parasites in potential blood donors.

    abstract:BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-016-1586-x

    authors: Portugal-Calisto D,Ferreira AR,Silva MS,Teodósio R

    更新日期:2016-11-09 00:00:00

  • Epidemiologic features of overseas imported malaria in the People's Republic of China.

    abstract:BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-016-1188-7

    authors: Li Z,Zhang Q,Zheng C,Zhou S,Sun J,Zhang Z,Geng Q,Zhang H,Wang L,Lai S,Hu W,Clements AC,Zhou XN,Yang W

    更新日期:2016-03-05 00:00:00

  • The ACTwatch project: methods to describe anti-malarial markets in seven countries.

    abstract:BACKGROUND:Policy makers, governments and donors are faced with an information gap when considering ways to improve access to artemisinin-based combination therapy (ACT) and malaria diagnostics including rapid diagnostic tests (RDTs). To help address some of these gaps, a five-year multi-country research project called...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-10-325

    authors: Shewchuk T,O'Connell KA,Goodman C,Hanson K,Chapman S,Chavasse D

    更新日期:2011-10-31 00:00:00

  • Do malaria ookinete surface proteins P25 and P28 mediate parasite entry into mosquito midgut epithelial cells?

    abstract:BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

    journal_title:Malaria journal

    pub_type: 杂志文章,评审

    doi:10.1186/1475-2875-4-15

    authors: Baton LA,Ranford-Cartwright LC

    更新日期:2005-02-25 00:00:00

  • Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia.

    abstract:BACKGROUND:The emergence of parasite drug resistance, especially Plasmodium falciparum, persists as a major obstacle for malaria control and elimination. To develop effective public health containment strategies, a clear understanding of factors that govern the emergence and spread of resistant parasites in the field i...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-453

    authors: Mharakurwa S,Sialumano M,Liu K,Scott A,Thuma P

    更新日期:2013-12-19 00:00:00

  • Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tag.

    abstract:BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2905-9

    authors: Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

    更新日期:2019-08-13 00:00:00

  • Atovaquone-proguanil in the treatment of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 cases.

    abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...

    journal_title:Malaria journal

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1475-2875-12-399

    authors: Cordel H,Cailhol J,Matheron S,Bloch M,Godineau N,Consigny PH,Gros H,Campa P,Bourée P,Fain O,Ralaimazava P,Bouchaud O

    更新日期:2013-11-07 00:00:00

  • Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacity.

    abstract:BACKGROUND:Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physicall...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03383-6

    authors: Briet O,Koenker H,Norris L,Wiegand R,Vanden Eng J,Thackeray A,Williamson J,Gimnig JE,Fortes F,Akogbeto M,Yadouleton AW,Ombok M,Bayoh MN,Mzilahowa T,Abílio AP,Mabunda S,Cuamba N,Diouf E,Konaté L,Hamainza B,Katebe-S

    更新日期:2020-08-28 00:00:00

  • Education and knowledge helps combating malaria, but not degedege: a cross-sectional study in Rufiji, Tanzania.

    abstract:BACKGROUND:Traditional medicine is readily available in Tanzania, and local terms like degedege is widely used for malaria-like illnesses, often associated with supernatural forces. Malaria prevention and intervention efforts can benefit from policy-makers' awareness of local perceptions and beliefs in the rural areas ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-200

    authors: Spjeldnæs AO,Kitua AY,Blomberg B

    更新日期:2014-05-28 00:00:00

  • Sexual forms obtained in a continuous in vitro cultured Colombian strain of Plasmodium falciparum (FCB2).

    abstract:BACKGROUND:The epidemiological control of malaria has been hampered by the appearance of parasite resistance to anti-malarial drugs and by the resistance of mosquito vectors to control measures. This has also been associated with weak transmission control, mostly due to poor control of asymptomatic patients associated ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-3142-y

    authors: Ararat-Sarria M,Prado CC,Camargo M,Ospina LT,Camargo PA,Curtidor H,Patarroyo MA

    更新日期:2020-02-03 00:00:00

  • The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01.

    abstract:BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03253-1

    authors: Fortpied J,Collignon S,Moniotte N,Renaud F,Bayat B,Lemoine D

    更新日期:2020-06-08 00:00:00

  • Creating mosquito-free outdoor spaces using transfluthrin-treated chairs and ribbons.

    abstract:BACKGROUND:Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. This compromises effectiveness of indoor interventions, notably long-lasting insecticide-treated nets...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03180-1

    authors: Masalu JP,Finda M,Killeen GF,Ngowo HS,Pinda PG,Okumu FO

    更新日期:2020-03-10 00:00:00

  • Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria.

    abstract:BACKGROUND:Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistanc...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03246-0

    authors: Dossou-Yovo LR,Ntoumi F,Koukouikila-Koussounda F,Vouvoungui JC,Adedoja A,Nderu D,Velavan TP,Lenga A

    更新日期:2020-05-08 00:00:00

  • Studies on mosquito biting risk among migratory rice farmers in rural south-eastern Tanzania and development of a portable mosquito-proof hut.

    abstract:BACKGROUND:Subsistence rice farmers in south-eastern Tanzania are often migratory, spending weeks or months tending to crops in distant fields along the river valleys and living in improvised structures known as Shamba huts, not fully protected from mosquitoes. These farmers also experience poor access to organized pre...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-016-1616-8

    authors: Swai JK,Finda MF,Madumla EP,Lingamba GF,Moshi IR,Rafiq MY,Majambere S,Okumu FO

    更新日期:2016-11-22 00:00:00

  • Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon.

    abstract:BACKGROUND:Transmission of malaria from man to mosquito depends on the presence of gametocytes, the sexual stage of Plasmodium parasites in the infected host. Naturally acquired antibodies against gametocytes exist and may play a role in controlling transmission by limiting the gametocyte development in the circulation...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1827-7

    authors: Gebru T,Ajua A,Theisen M,Esen M,Ngoa UA,Issifou S,Adegnika AA,Kremsner PG,Mordmüller B,Held J

    更新日期:2017-04-26 00:00:00

  • Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity.

    abstract:BACKGROUND:Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect malaria epidemiology. The different kinds of heterogeneity are likely to be correlated. Little is known about their impact on the shape...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-132

    authors: Ross A,Smith T

    更新日期:2010-05-17 00:00:00

  • Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, Honduras.

    abstract:BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-014-0537-7

    authors: Abdallah JF,Okoth SA,Fontecha GA,Torres RE,Banegas EI,Matute ML,Bucheli ST,Goldman IF,de Oliveira AM,Barnwell JW,Udhayakumar V

    更新日期:2015-01-21 00:00:00

  • Avian haemosporidian persistence and co-infection in great tits at the individual level.

    abstract:BACKGROUND:Many studies have tracked the distribution and persistence of avian haemosporidian communities across space and time at the population level, but few studies have investigated these aspects of infection at the individual level over time. Important aspects of parasite infection at the individual level can be ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-40

    authors: van Rooyen J,Lalubin F,Glaizot O,Christe P

    更新日期:2013-01-30 00:00:00

  • Cytokine and chemokine profile of the innate and adaptive immune response of Schistosoma haematobium and Plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon.

    abstract:BACKGROUND:Helminths and malaria are among the most prevalent infectious diseases in the world. They both occur in tropical area where they often affect the same populations. There are studies suggesting an effect of helminths on malariometric indices. For example, malaria attacks as well as disease severity has been s...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-015-0608-4

    authors: Ateba-Ngoa U,Adegnika AA,Zinsou JF,Kassa Kassa RF,Smits H,Massinga-Loembe M,Mordmüller B,Kremsner PG,Yazdanbakhsh M

    更新日期:2015-02-25 00:00:00

  • Biology and bionomics of malaria vectors in India: existing information and what more needs to be known for strategizing elimination of malaria.

    abstract::India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...

    journal_title:Malaria journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12936-019-3011-8

    authors: Subbarao SK,Nanda N,Rahi M,Raghavendra K

    更新日期:2019-12-03 00:00:00

  • Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine.

    abstract:BACKGROUND:A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria. METHODS:Filter-paper blo...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2977-6

    authors: Ikegbunam MN,Nkonganyi CN,Thomas BN,Esimone CO,Velavan TP,Ojurongbe O

    更新日期:2019-10-07 00:00:00

  • Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission.

    abstract:BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-163

    authors: Mutanda AL,Cheruiyot P,Hodges JS,Ayodo G,Odero W,John CC

    更新日期:2014-04-30 00:00:00

  • Quantifying late-stage host-seeking behaviour of Anopheles gambiae at the insecticidal net interface using a baited-box bioassay.

    abstract:BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03213-9

    authors: Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

    更新日期:2020-04-07 00:00:00

  • Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population.

    abstract:BACKGROUND:Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite antigens are the focus of malaria vaccine development efforts. Polymorphisms in several merozoite antigen-encoding genes are th...

    journal_title:Malaria journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12936-016-1304-8

    authors: Ochola-Oyier LI,Okombo J,Wagatua N,Ochieng J,Tetteh KK,Fegan G,Bejon P,Marsh K

    更新日期:2016-05-06 00:00:00

  • Splenic infarction during Plasmodium ovale acute malaria: first case reported.

    abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-288

    authors: Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

    更新日期:2010-10-18 00:00:00

  • A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria.

    abstract:BACKGROUND:Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS:In this study the Binax NOW Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and ...

    journal_title:Malaria journal

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1475-2875-10-300

    authors: van Gool T,van Wolfswinkel ME,Koelewijn R,van Thiel PP,Jacobs J,van Hellemond JJ,van Genderen PJ

    更新日期:2011-10-14 00:00:00

  • Allomonal effect of breath contributes to differential attractiveness of humans to the African malaria vector Anopheles gambiae.

    abstract::BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-3-1

    authors: Mukabana WR,Takken W,Killeen GF,Knols BG

    更新日期:2004-01-29 00:00:00

  • Synergism from combinations of infection-blocking malaria vaccines.

    abstract::Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens. These challenges are illustrated by using a mathematical model to describe the association between the pr...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-280

    authors: White MT,Smith DL

    更新日期:2013-08-08 00:00:00

  • How many mosquito nets are needed to achieve universal coverage? Recommendations for the quantification and allocation of long-lasting insecticidal nets for mass campaigns.

    abstract:BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-330

    authors: Kilian A,Boulay M,Koenker H,Lynch M

    更新日期:2010-11-18 00:00:00

  • Performance evaluation of machine learning-based infectious screening flags on the HORIBA Medical Yumizen H550 Haematology Analyzer for vivax malaria and dengue fever.

    abstract:BACKGROUND:Automated detection of malaria and dengue infection has been actively researched for more than two decades. Although many improvements have been achieved, these solutions remain too expensive for most laboratories and clinics in developing countries. The low range HORIBA Medical Haematology Analyzer, Yumizen...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03502-3

    authors: Dharap P,Raimbault S

    更新日期:2020-11-23 00:00:00