Abstract:
BACKGROUND:Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. This compromises effectiveness of indoor interventions, notably long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS). This study characterized common peri-domestic spaces in rural south-eastern Tanzania, and assessed protective efficacy against mosquitoes of hessian fabric mats and ribbons treated with the spatial repellent, transfluthrin, and fitted to chairs and outdoor kitchens, respectively. METHODS:Two hundred households were surveyed, and their most-used peri-domestic spaces physically characterized. Protective efficacies of locally-made transfluthrin-emanating chairs and hessian ribbons were tested in outdoor environments of 28 households in dry and wet seasons, using volunteer-occupied exposure-free double net traps. CDC light traps were used to estimate host-seeking mosquito densities within open-structure outdoor kitchens. Field-collected Anopheles arabiensis and Anopheles funestus mosquitoes were exposed underneath the chairs to estimate 24 h-mortality. Finally, The World Health Organization insecticide susceptibility tests were conducted on wild-caught Anopheles from the villages. RESULTS:Approximately half (52%) of houses had verandas. Aside from these verandas, most houses also had peri-domestic spaces where residents stayed most times (67% of houses with verandas and 94% of non-veranda houses). Two-thirds of these spaces were sited under trees, and only one third (34.4%) were built-up. The outdoor structures were usually makeshift kitchens having roofs and partial walls. Transfluthrin-treated chairs reduced outdoor-biting An. arabiensis densities by 70-85%, while transfluthrin-treated hessian ribbons fitted to the outdoor kitchens caused 77-81% reduction in the general peri-domestic area. Almost all the field-collected An. arabiensis (99.4%) and An. funestus (100%) exposed under transfluthrin-treated chairs died. The An. arabiensis were susceptible to non-pyrethroids (pirimiphos methyl and bendiocarb), but resistant to pyrethroids commonly used on LLINs (deltamethrin and permethrin). CONCLUSION:Most houses had actively-used peri-domestic outdoor spaces where exposure to mosquitoes occurred. The transfluthrin-treated chairs and ribbons reduced outdoor-biting malaria vectors in these peri-domestic spaces, and also elicited significant mortality among pyrethroid-resistant field-caught malaria vectors. These two new prototype formats for transfluthrin emanators, if developed further, may constitute new options for complementing LLINs and IRS with outdoor protection against malaria and other mosquito-borne pathogens in areas where peri-domestic human activities are common.
journal_name
Malar Jjournal_title
Malaria journalauthors
Masalu JP,Finda M,Killeen GF,Ngowo HS,Pinda PG,Okumu FOdoi
10.1186/s12936-020-03180-1subject
Has Abstractpub_date
2020-03-10 00:00:00pages
109issue
1issn
1475-2875pii
10.1186/s12936-020-03180-1journal_volume
19pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-80
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1750-y
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission. Primaquine has been administered together on the first or the last day of conventional treatment but the impact of primaquine timing has never bee...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-020-3121-3
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-103
更新日期:2014-03-17 00:00:00
abstract:BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2642-0
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-1012-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-160
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:As a result of the reintroduction of malaria in the Republic of Korea (ROK) in 1993 and the threat to military and civilian populations, the Korea Military National Defense (MND) increased emphasis on vector control in 2012 at ROK Army (ROKA) installations located near the DMZ, while decreasing chemoprophyla...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1301-y
更新日期:2016-05-05 00:00:00
abstract::BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-1
更新日期:2004-01-29 00:00:00
abstract:BACKGROUND:The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R and G353V) were rece...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03281-x
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Genetically-modified (GM) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. Public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (GMOs) face strong scepticism in d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-128
更新日期:2010-05-14 00:00:00
abstract:BACKGROUND:Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistan...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03543-8
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Global malaria control strategies highlight the need to increase early uptake of effective antimalarials for childhood fevers in endemic settings, based on a presumptive diagnosis of malaria in this age group. Many control programmes identify private medicine sellers as important targets to promote effective...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-57
更新日期:2007-05-10 00:00:00
abstract:BACKGROUND:Malaria remains a major human health problem, with no licensed vaccine currently available. Malaria infections initiate when infectious Plasmodium sporozoites are transmitted by Anopheline mosquitoes during their blood meal. Investigations of the malaria sporozoite are, therefore, of clear medical importance...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-421
更新日期:2012-12-17 00:00:00
abstract:BACKGROUND:Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria, but may probably also worsen the severity of imported cases. The ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-265
更新日期:2013-07-31 00:00:00
abstract:BACKGROUND:As malaria transmission declines, it becomes more geographically focused and more likely due to asymptomatic and non-falciparum infections. To inform malaria elimination planning in the context of this changing epidemiology, local assessments on the risk factors for malaria infection are necessary, yet chall...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1523-z
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, an...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-111
更新日期:2006-11-20 00:00:00
abstract:BACKGROUND:Many studies have tracked the distribution and persistence of avian haemosporidian communities across space and time at the population level, but few studies have investigated these aspects of infection at the individual level over time. Important aspects of parasite infection at the individual level can be ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-40
更新日期:2013-01-30 00:00:00
abstract:BACKGROUND:Long regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple locations across Southeast Asia. Gene...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03249-x
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the profile of antibodies against several antigens of Plasmodium vivax and Plasmodium falciparum in Mandalay, Myanmar. METHODS:Malaria parasites were identified by microscopic examination. To test the antibodies against P. vivax and P. falciparum in sera, an indirect...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-228
更新日期:2011-08-06 00:00:00
abstract:BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2451-x
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementation and effects of IPTp-SP were collected in a rural clinic in Southern Senegal. METHODS:Women se...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-234
更新日期:2008-11-07 00:00:00
abstract:BACKGROUND:New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2165-5
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-172
更新日期:2014-05-05 00:00:00
abstract:BACKGROUND:The pro-inflammatory S100 calcium binding protein A8 (S100A8) is elevated in the serum of patients with Plasmodium falciparum malaria, but its function in Plasmodium vivax malaria is not yet clear. This function was investigated in P. vivax-infected patients in this study. METHODS:The level of S100A8 in the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0855-4
更新日期:2015-10-05 00:00:00
abstract::Malaria currently causes more harm to human beings than any other parasitic disease, and disproportionally affects low-income populations. The ethical issues raised by efforts to control or eliminate malaria have received little explicit analysis, in comparison with other major diseases of poverty. While some ethical ...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-015-1042-3
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-203
更新日期:2011-07-25 00:00:00
abstract:BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-6
更新日期:2011-01-12 00:00:00
abstract:BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-31
更新日期:2010-01-23 00:00:00
abstract:BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-156
更新日期:2011-06-08 00:00:00