Ethical aspects of malaria control and research.

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Very few data on anti-malarial efficacy are available from the Democratic Republic of Congo (DRC). DRC changed its anti-malarial treatment policy to amodiaquine (AQ) and artesunate (AS) in 2005. METHODS:The results of two in vivo efficacy studies, which tested AQ and sulphadoxine-pyrimethamine (SP) monother...

journal_title：Malaria journal

authors： Bonnet M,Broek Iv,van Herp M,Urrutia PP,van Overmeir C,Kyomuhendo J,Ndosimao CN,Ashley E,Guthmann JP

更新日期：2009-08-10 00:00:00

abstract：:The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways ...

journal_title：Malaria journal

authors： Bozdech Z,Ginsburg H

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:The accuracy of the World Health Organization method of estimating malaria parasite density from thick blood smears by assuming a white blood cell (WBC) count of 8,000/μL has been questioned in several studies. Since epidemiological investigations, anti-malarial efficacy trials and routine laboratory reporti...

journal_title：Malaria journal

authors： Laman M,Moore BR,Benjamin J,Padapu N,Tarongka N,Siba P,Betuela I,Mueller I,Robinson LJ,Davis TM

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated with artemisinin resistance, and pfmdr1, associated with lumefantrine resistance, have not been s...

journal_title：Malaria journal

authors： Ljolje D,Dimbu PR,Kelley J,Goldman I,Nace D,Macaia A,Halsey ES,Ringwald P,Fortes F,Udhayakumar V,Talundzic E,Lucchi NW,Plucinski MM

更新日期：2018-02-20 00:00:00

abstract：:The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...

journal_title：Malaria journal

authors： Cinquetti G,Banal F,Rondel C,Plancade D,de Saint Roman C,Adriamanantena D,Ragot C,Védy S,Graffin B

更新日期：2010-10-18 00:00:00

abstract：BACKGROUND:Malaria can be transmitted by blood transfusion through donations collected from asymptomatic or parasitic donors. The parasites are released into the bloodstream during its life cycle and will therefore be present in donated blood by infected individuals. All cases of transfusion-transmitted malaria (TTM) n...

journal_title：Malaria journal

authors： Batista-Dos-Santos SA,Freitas DRC,Raiol M,Cabral GF,Feio AC,Póvoa MM,Cunha MG,Ribeiro-Dos-Santos Â

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin wer...

journal_title：Malaria journal

authors： Antonio-Nkondjio C,Tene Fossog B,Kopya E,Poumachu Y,Menze Djantio B,Ndo C,Tchuinkam T,Awono-Ambene P,Wondji CS

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation. METHODS:Retrospective analysis of data collected through the Manhiça morbidity surveillance sy...

journal_title：Malaria journal

authors： Guinovart C,Bassat Q,Sigaúque B,Aide P,Sacarlal J,Nhampossa T,Bardají A,Nhacolo A,Macete E,Mandomando I,Aponte JJ,Menéndez C,Alonso PL

更新日期：2008-02-26 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...

journal_title：Malaria journal

authors： Pousibet-Puerto J,Salas-Coronas J,Sánchez-Crespo A,Molina-Arrebola MA,Soriano-Pérez MJ,Giménez-López MJ,Vázquez-Villegas J,Cabezas-Fernández MT

更新日期：2016-07-02 00:00:00

abstract：BACKGROUND:Kohat district is one of the medium intensity malaria transmission areas in Pakistan where asymptomatic carriers are likely to form a reservoir of infection. This study was done to explore the possibility of using microscopy, rapid diagnostic testing (RDT), real time polymerase chain reaction (RT-PCR) and RT...

journal_title：Malaria journal

authors： Naeem MA,Ahmed S,Khan SA

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...

journal_title：Malaria journal

authors： Kilian A,Boulay M,Koenker H,Lynch M

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:Isolation of a concentrated, living preparation of malarial parasite-infected red blood cells (PRBCs) that have low contamination of white blood cells (WBCs) facilitates research on the molecular, biochemical and immunological aspects of malarial parasites. This is currently carried out by a two-step method,...

journal_title：Malaria journal

authors： Trang DT,Huy NT,Kariu T,Tajima K,Kamei K

更新日期：2004-03-17 00:00:00

abstract：BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...

journal_title：Malaria journal

authors： Kudella PW,Moll K,Wahlgren M,Wixforth A,Westerhausen C

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and radio devices. Fluorescent dust is the most commonly used method to distinguish released individuals f...

journal_title：Malaria journal

authors： Aviles EI,Rotenberry RD,Collins CM,Dotson EM,Benedict MQ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Drug combination therapy is the frontline of malaria treatment. There is an ever-accelerating need for new, efficacious combination therapies active against drug resistant malaria. Proven drugs already in the treatment pipeline, such as the quinolines, are important components of current combination therapy ...

journal_title：Malaria journal

authors： Gorka AP,Jacobs LM,Roepe PD

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...

journal_title：Malaria journal

authors： Srisutham S,Suwannasin K,Mathema VB,Sriprawat K,Smithuis FM,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

journal_title：Malaria journal

authors： Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

更新日期：2013-12-20 00:00:00

abstract：BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...

journal_title：Malaria journal

authors： Nyakoe NK,Taylor RP,Makumi JN,Waitumbi JN

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

journal_title：Malaria journal

authors： Baton LA,Ranford-Cartwright LC

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...

journal_title：Malaria journal

authors： Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Insect vectors, namely mosquitoes (Diptera: Culicidae), are compulsory for malaria parasites (Plasmodium spp.) to complete their life cycle. Despite this, little is known about vector competence of different mosquito species for the transmission of avian malaria parasites. METHODS:In this study, nested PCR ...

journal_title：Malaria journal

authors： Schoener E,Uebleis SS,Butter J,Nawratil M,Cuk C,Flechl E,Kothmayer M,Obwaller AG,Zechmeister T,Rubel F,Lebl K,Zittra C,Fuehrer HP

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:As in other countries of the Greater Mekong Sub-region (GMS), the private health sector constitutes a significant avenue where malaria services are provided and presents a unique opportunity for public-private collaboration. In September 2008, a public-private mix (PPM) strategy was launched initially in fou...

journal_title：Malaria journal

authors： Simmalavong N,Phommixay S,Kongmanivong P,Sichanthongthip O,Hongvangthong B,Gopinath D,Sintasath DM

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:As a result of the reintroduction of malaria in the Republic of Korea (ROK) in 1993 and the threat to military and civilian populations, the Korea Military National Defense (MND) increased emphasis on vector control in 2012 at ROK Army (ROKA) installations located near the DMZ, while decreasing chemoprophyla...

journal_title：Malaria journal

authors： Chang KS,Yoo DH,Ju YR,Lee WG,Roh JY,Kim HC,Klein TA,Shin EH

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:The epidemiological control of malaria has been hampered by the appearance of parasite resistance to anti-malarial drugs and by the resistance of mosquito vectors to control measures. This has also been associated with weak transmission control, mostly due to poor control of asymptomatic patients associated ...

journal_title：Malaria journal

authors： Ararat-Sarria M,Prado CC,Camargo M,Ospina LT,Camargo PA,Curtidor H,Patarroyo MA

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Malaria is one of the most severe global public health problems worldwide, particularly in Africa, where Nigeria has the greatest number of malaria cases. This community-based study was designed to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices ...

journal_title：Malaria journal

authors： Dawaki S,Al-Mekhlafi HM,Ithoi I,Ibrahim J,Atroosh WM,Abdulsalam AM,Sady H,Elyana FN,Adamu AU,Yelwa SI,Ahmed A,Al-Areeqi MA,Subramaniam LR,Nasr NA,Lau YL

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:The use of artemisinin-based combination therapy (ACT) at the community level has been advocated as a means to increase access to effective antimalarial medicines by high risk groups living in underserved areas, mainly in sub-Saharan Africa. This strategy has been shown to be feasible and acceptable to the c...

journal_title：Malaria journal

authors： Ajayi IO,Browne EN,Bateganya F,Yar D,Happi C,Falade CO,Gbotosho GO,Yusuf B,Boateng S,Mugittu K,Cousens S,Nanyunja M,Pagnoni F

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. This compromises effectiveness of indoor interventions, notably long-lasting insecticide-treated nets...

journal_title：Malaria journal

authors： Masalu JP,Finda M,Killeen GF,Ngowo HS,Pinda PG,Okumu FO

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00