Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies.

abstract：BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...

journal_title：Malaria journal

authors： Ménard D,Andrianina NN,Ramiandrasoa Z,Randriamanantena A,Rasoarilalao N,Jahevitra M,Ratsimbasoa A,Tuseo L,Raveloson A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:The relationship between mosquito development and temperature is one of the keys to understanding the current and future dynamics and distribution of vector-borne diseases such as malaria. Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densitie...

journal_title：Malaria journal

authors： Paaijmans KP,Imbahale SS,Thomas MB,Takken W

更新日期：2010-07-09 00:00:00

abstract：BACKGROUND:As the ecology of mosquito larvae can be complex there is need to develop a rational framework for undertaking larval ecological studies. Local environmental characteristics, such as altitude, climate and land use, can significantly impact on phenology and population dynamics of mosquito larvae, and indirect...

journal_title：Malaria journal

authors： Imbahale SS,Paaijmans KP,Mukabana WR,van Lammeren R,Githeko AK,Takken W

更新日期：2011-04-10 00:00:00

abstract：BACKGROUND:Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS:In February/March 2006, a survey was...

journal_title：Malaria journal

authors： Tipke M,Louis VR,Yé M,De Allegri M,Beiersmann C,Sié A,Mueller O,Jahn A

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:Subsistence rice farmers in south-eastern Tanzania are often migratory, spending weeks or months tending to crops in distant fields along the river valleys and living in improvised structures known as Shamba huts, not fully protected from mosquitoes. These farmers also experience poor access to organized pre...

journal_title：Malaria journal

authors： Swai JK,Finda MF,Madumla EP,Lingamba GF,Moshi IR,Rafiq MY,Majambere S,Okumu FO

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes. Measuring the infectivity of low gametocyte densities has become increa...

journal_title：Malaria journal

authors： Reuling IJ,Stone WJR,van de Vegte-Bolmer M,van Gemert GJ,Siebelink-Stoter R,Graumans W,Lanke K,Bousema T,Sauerwein RW

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...

journal_title：Malaria journal

authors： Kudella PW,Moll K,Wahlgren M,Wixforth A,Westerhausen C

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS:The study was conducted with a s...

journal_title：Malaria journal

authors： Barua P,Chandrasiri UP,Beeson JG,Dewey KG,Maleta K,Ashorn P,Rogerson SJ

更新日期：2018-02-07 00:00:00

abstract：:Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...

journal_title：Malaria journal

authors： Samuels AM,Awino N,Odongo W,Abong'o B,Gimnig J,Otieno K,Shi YP,Were V,Allen DR,Were F,Sang T,Obor D,Williamson J,Hamel MJ,Patrick Kachur S,Slutsker L,Lindblade KA,Kariuki S,Desai M

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:The accuracy of the World Health Organization method of estimating malaria parasite density from thick blood smears by assuming a white blood cell (WBC) count of 8,000/μL has been questioned in several studies. Since epidemiological investigations, anti-malarial efficacy trials and routine laboratory reporti...

journal_title：Malaria journal

authors： Laman M,Moore BR,Benjamin J,Padapu N,Tarongka N,Siba P,Betuela I,Mueller I,Robinson LJ,Davis TM

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Over the past several years, thousands of microRNAs (miRNAs) have been identified in the genomes of various insects through cloning and sequencing or even by computational prediction. However, the number of miRNAs identified in anopheline species is low and little is known about their role. The mosquito Anop...

journal_title：Malaria journal

authors： Allam M,Spillings BL,Abdalla H,Mapiye D,Koekemoer LL,Christoffels A

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:The study of the biology, transmission and pathogenesis of Plasmodium vivax is hindered due to the lack of a robustly propagating, continuous culture of this parasite. The current culture system for P. vivax parasites still suffered from consistency and difficulties in long-term maintenance of parasites in c...

journal_title：Malaria journal

authors： Roobsoong W,Tharinjaroen CS,Rachaphaew N,Chobson P,Schofield L,Cui L,Adams JH,Sattabongkot J

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in a malaria-endemic region of Papua New Guinea (PNG). METHODS AND FINDINGS:Individuals with Plasmodi...

journal_title：Malaria journal

authors： Karl S,David M,Moore L,Grimberg BT,Michon P,Mueller I,Zborowski M,Zimmerman PA

更新日期：2008-04-25 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...

journal_title：Malaria journal

authors： Kilian A,Boulay M,Koenker H,Lynch M

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:After the decrease in clinical malaria incidence observed in Mozambique until 2009, a steady resurgence of cases per year has been reported nationally, reaching alarming levels in 2014. However, little is known about the clinical profile of the cases presented, or the possible epidemiological factors contrib...

journal_title：Malaria journal

authors： Galatas B,Guinovart C,Bassat Q,Aponte JJ,Nhamússua L,Macete E,Saúte F,Alonso P,Aide P

更新日期：2016-08-31 00:00:00

abstract：:Spain declared the elimination of malaria in 1964. In non-endemic areas, the overwhelming majority of malaria cases are acquired abroad, and locally acquired infections are rare events. In Spain, malaria is a statutorily notifiable disease. During these fifty years more than ten thousand malaria cases have been report...

journal_title：Malaria journal

authors： Velasco E,Gomez-Barroso D,Varela C,Diaz O,Cano R

更新日期：2017-06-29 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...

journal_title：Malaria journal

authors： Thwing J,Ba F,Diaby A,Diedhiou Y,Sylla A,Sall G,Diouf MB,Gueye AB,Gaye S,Ndiop M,Cisse M,Ndiaye D,Ba M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...

journal_title：Malaria journal

authors： Mutanda AL,Cheruiyot P,Hodges JS,Ayodo G,Odero W,John CC

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...

journal_title：Malaria journal

authors： Ba H,Duffy CW,Ahouidi AD,Deh YB,Diallo MY,Tandia A,Conway DJ

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Dihydroartemisinin (DHA) is a component of artemisinin-based combination therapy (ACT), which is widely recommended for treatment of uncomplicated falciparum malaria. DHA is also the main metabolite of artemether and artesunate, both of which are used in ACT. Due to auto-induction metabolism, declining plasm...

journal_title：Malaria journal

authors： Zang M,Zhu F,Zhao L,Yang A,Li X,Liu H,Xing J

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Passerine birds are frequently infected with diverse haemosporidian parasites. While infections are traditionally considered benign in wild birds, recent studies demonstrated mortalities of passerine species due to exo-erythrocytic development of the parasites, which can damage organs in affected hosts. Howe...

journal_title：Malaria journal

authors： Himmel T,Harl J,Pfanner S,Nedorost N,Nowotny N,Weissenböck H

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Malaria can be eradicated from islands. To assess the prospects for eradication of malaria from the island of Príncipe in the Gulf of Guinea, we fitted a mathematical model to age-prevalence curves and thus obtained estimates of the vectorial capacity and of the basic reproductive number (R0) for malaria. M...

journal_title：Malaria journal

authors： Hagmann R,Charlwood JD,Gil V,Ferreira C,do Rosário V,Smith TA

更新日期：2003-06-18 00:00:00

abstract：BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...

journal_title：Malaria journal

authors： Kisinza WN,Nkya TE,Kabula B,Overgaard HJ,Massue DJ,Mageni Z,Greer G,Kaspar N,Mohamed M,Reithinger R,Moore S,Lorenz LM,Magesa S

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Monitoring and evaluation of malaria programmes may require a combination of approaches to detect any effects of control. This is particularly true at lower transmission levels where detecting both infection and exposure to infection will provide additional evidence of any change. This paper describes use of...

journal_title：Malaria journal

authors： Stevenson JC,Stresman GH,Baidjoe A,Okoth A,Oriango R,Owaga C,Marube E,Bousema T,Cox J,Drakeley C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) programmes in particular. CASE DESCRIPTION:The institutional evolution of a city-level, community-based LSM programme over 14 y...

journal_title：Malaria journal

authors： Chaki PP,Kannady K,Mtasiwa D,Tanner M,Mshinda H,Kelly AH,Killeen GF

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of the human populations it affects. Low population densities in rural areas and high population densit...

journal_title：Malaria journal

authors： Tatem AJ,Guerra CA,Kabaria CW,Noor AM,Hay SI

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:The standard in vitro protocol currently in use for drug testing against Plasmodium falciparum, based on the incorporation of the purine [3H]-hypoxanthine, has two serious drawbacks. Firstly it is unsuitable for the testing of drugs that directly or indirectly impact on purine salvage or metabolism. Secondly...

journal_title：Malaria journal

authors： Quashie NB,de Koning HP,Ranford-Cartwright LC

更新日期：2006-10-31 00:00:00

abstract：BACKGROUND:Community distribution of anti-malarials and antibiotics has been recommended as a strategy to reduce the under-five mortality due to febrile illnesses in sub-Saharan Africa. However, drugs distributed in these interventions have been considered weak by some caretakers and utilization of community medicine d...

journal_title：Malaria journal

authors： Rutebemberwa E,Nsabagasani X,Pariyo G,Tomson G,Peterson S,Kallander K

更新日期：2009-06-12 00:00:00