Improvement of culture conditions for long-term in vitro culture of Plasmodium vivax.

abstract：BACKGROUND:In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of mal...

journal_title：Malaria journal

authors： Ademolue TW,Aniweh Y,Kusi KA,Awandare GA

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Relatively little is known about the prevalence of blood parasites in shorebirds, especially those breeding in the tropics. The prevalence of blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon was assessed in blood samples from Kentish plovers and cream-coloured coursers in Cape Verde, ...

journal_title：Malaria journal

authors： Martínez-de la Puente J,Eberhart-Phillips LJ,Cristina Carmona-Isunza M,Zefania S,Navarro MJ,Kruger O,Hoffman JI,Székely T,Figuerola J

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:As malaria transmission declines, it becomes more geographically focused and more likely due to asymptomatic and non-falciparum infections. To inform malaria elimination planning in the context of this changing epidemiology, local assessments on the risk factors for malaria infection are necessary, yet chall...

journal_title：Malaria journal

authors： Herdiana H,Cotter C,Coutrier FN,Zarlinda I,Zelman BW,Tirta YK,Greenhouse B,Gosling RD,Baker P,Whittaker M,Hsiang MS

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:The effectiveness of vector control on malaria transmission by long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) depends on the vectors entering houses to blood feed and rest when people are inside houses. In the Solomon Islands, significant reductions in malaria have been achieved in...

journal_title：Malaria journal

authors： Russell TL,Beebe NW,Bugoro H,Apairamo A,Chow WK,Cooper RD,Collins FH,Lobo NF,Burkot TR

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Sulphadoxine-pyrimethamine (SP) has been in use for the treatment of uncomplicated falciparum malaria in Malaysia since the 1970s and is still widely employed in spite of widespread clinical resistance. Resistance to SP is known to be mediated by mutations in the pfdhfr and pfdhps genes. The aim of the prese...

journal_title：Malaria journal

authors： Abdullah NR,Norahmad NA,Jelip J,Sulaiman LH,Mohd Sidek H,Ismail Z,Noedl H

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:Molecular tools for detection of low-density asymptomatic Plasmodium infections are needed in malaria elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic malaria in Zanzibar. ...

journal_title：Malaria journal

authors： Morris U,Khamis M,Aydin-Schmidt B,Abass AK,Msellem MI,Nassor MH,González IJ,Mårtensson A,Ali AS,Björkman A,Cook J

更新日期：2015-05-17 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which consists of collecting information in real time and analysing this information for decision-making....

journal_title：Malaria journal

authors： Thomas A,Bakai TA,Atcha-Oubou T,Tchadjobo T,Voirin N

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:The WHO has reported that RDT and microscopy-confirmed malaria cases have declined in recent years. However, it is still unclear if this reflects a real decrease in incidence in Bangladesh, as particularly the hilly and forested areas of the Chittagong Hill Tract (CHT) Districts report more than 80% of all c...

journal_title：Malaria journal

authors： Starzengruber P,Fuehrer HP,Ley B,Thriemer K,Swoboda P,Habler VE,Jung M,Graninger W,Khan WA,Haque R,Noedl H

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,Bottieau E,Van Esbroeck M,Bruggeman C,Jacobs J

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich prot...

journal_title：Malaria journal

authors： Nyunt MH,Kyaw MP,Win KK,Myint KM,Nyunt KM

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:Early diagnosis and prompt treatment including appropriate home-based treatment of malaria is a major strategy for malaria control. A major determinant of clinical outcome in case management is compliance and adherence to effective antimalarial regimen. Home-based malaria treatment with inappropriate medicin...

journal_title：Malaria journal

authors： Orimadegun AE,Amodu OK,Olumese PE,Omotade OO

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito. METHODS:381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened...

journal_title：Malaria journal

authors： Maharaj R,Maharaj V,Crouch NR,Bhagwandin N,Folb PI,Pillay P,Gayaram R

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...

journal_title：Malaria journal

authors： Taylor DW,Bobbili N,Khadka VS,Quakyi IA,Leke RG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...

journal_title：Malaria journal

authors： Dow GS,Gettayacamin M,Hansukjariya P,Imerbsin R,Komcharoen S,Sattabongkot J,Kyle D,Milhous W,Cozens S,Kenworthy D,Miller A,Veazey J,Ohrt C

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) to provide in-home diagnosis and treatment of these common childhood illnesses. For severely ill ch...

journal_title：Malaria journal

authors： English L,Miller JS,Mbusa R,Matte M,Kenney J,Bwambale S,Ntaro M,Patel P,Mulogo E,Stone GS

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Approximately 50 million people (60 %) live in malaria risk areas in Ethiopia, at altitudes below 2000 m. According to official data, 60-70 % of malaria cases are due to Plasmodium falciparum, and 40-30 % by Plasmodium vivax. The species Plasmodium ovale was detected in 2013 in the northwest of the country, ...

journal_title：Malaria journal

authors： Díaz PB,Lozano PM,Rincón JM,García L,Reyes F,Llanes AB

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:The Plasmodium falciparum protein RH5 is an adhesin molecule essential for parasite invasion of erythrocytes. Recent studies show that anti-PfRH5 sera have potent invasion-inhibiting activities, supporting the idea that the PfRH5 antigen could form the basis of a vaccine. Therefore, epitopes recognized by ne...

journal_title：Malaria journal

authors： Ord RL,Caldeira JC,Rodriguez M,Noe A,Chackerian B,Peabody DS,Gutierrez G,Lobo CA

更新日期：2014-08-18 00:00:00

abstract：BACKGROUND:Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is ...

journal_title：Malaria journal

authors： Wilmot D,Ameyaw EO,Amoako-Sakyi D,Boampong JN,Quashie NB

更新日期：2017-03-04 00:00:00

abstract：BACKGROUND:The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom®, Odypharm Ltd), which involves treatment over two days...

journal_title：Malaria journal

authors： Menan H,Faye O,Same-Ekobo A,Oga AS,Faye B,Kiki Barro CP,Kuete T,N'diaye JL,Vicky AM,Tine R,Yavo W,Kane D,Kassi KF,Kone M

更新日期：2011-07-08 00:00:00

abstract：BACKGROUND:Increased control has produced remarkable reductions of malaria in some parts of sub-Saharan Africa, including Rwanda. In the southern highlands, near the district capital of Butare (altitude, 1,768 m), a combined community-and facility-based survey on Plasmodium infection was conducted early in 2010. METHO...

journal_title：Malaria journal

authors： Gahutu JB,Steininger C,Shyirambere C,Zeile I,Cwinya-Ay N,Danquah I,Larsen CH,Eggelte TA,Uwimana A,Karema C,Musemakweri A,Harms G,Mockenhaupt FP

更新日期：2011-05-18 00:00:00

abstract：BACKGROUND:Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not c...

journal_title：Malaria journal

authors： Mahamar A,Issiaka D,Barry A,Attaher O,Dembele AB,Traore T,Sissoko A,Keita S,Diarra BS,Narum DL,Duffy PE,Dicko A,Fried M

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...

journal_title：Malaria journal

authors： Na-Bangchang K,Ruengweerayut R,Mahamad P,Ruengweerayut K,Chaijaroenkul W

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...

journal_title：Malaria journal

authors： Shaukat AM,Breman JG,McKenzie FE

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:Malaria is a leading global cause of preventable morbidity and mortality, especially in sub-Saharan Africa, despite recent advances in treatment and prevention technologies. Scale-up and wide distribution of long-lasting insecticide-treated nets (LLINs) could rapidly decrease malarial disease in endemic area...

journal_title：Malaria journal

authors： Dye TD,Apondi R,Lugada ES,Kahn JG,Smith J,Othoro C

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

journal_title：Malaria journal

authors： Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...

journal_title：Malaria journal

authors： Tougan T,Toya Y,Uchihashi K,Horii T

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity ...

journal_title：Malaria journal

authors： Mendes C,Salgueiro P,Gonzalez V,Berzosa P,Benito A,do Rosário VE,de Sousa B,Cano J,Arez AP

更新日期：2013-03-27 00:00:00

abstract：:The classic formulae in malaria epidemiology are reviewed that relate entomological parameters to malaria transmission, including mosquito survivorship and age-at-infection, the stability index (S), the human blood index (HBI), proportion of infected mosquitoes, the sporozoite rate, the entomological inoculation rate ...

journal_title：Malaria journal

authors： Smith DL,McKenzie FE

更新日期：2004-06-04 00:00:00